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Parkinson’s and psychosis
na
6
Pharmacology
Professional
05/02/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
levodopa (L-dopa)
Definition
-market name = Sinemet
-must be combined with carbidopa to prevent rapid peripheral decarboxylation and subsequent inabilily to cross blood-brain barrier
-treatment of parkinson’s
Term
apomorphine
Definition
often used during a poison emergency
Term
thioridazine (Mellaril)
Definition
-Strong dopamine D2 receptor antagonist for psychosis that also has strong anticholinergic properties, and hence has a lower probability of causing parkinsonism-like motor side effects
Term
haloperidol (Haldol)
Definition
-strong dopamine D2 receptor antagonist for psychosis that has a high probability of causing parkinsonism-like motor side effects
-low anticholinergic properties
Term
risperidone (Risperdal)
Definition
-Atypical antipsychotic that is also a strong antagonist of BOTH serotonin 5-HT2 and dopamine D2 receptors.
-Consequently, this drug causes LESS motor side effects that do “typical” antipsychotics, although it may also increase anxiety/depression
Term
aripiprazole (Abilify)
Definition
-new class of atypical antipsychotic all by itself
-mild presynaptic D2 agonist and a mild postsynaptic D2 antagonist
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