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Parasitic diseases
Lecture 24
18
Pharmacology
Professional
03/16/2013

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Cards

Term
What diseases are protozoan?
Definition
- Giardia
- Amebiasis
- Malaria
- Chagas
Term
What diseases are helminthic?
Definition
- Ascariasis = roundworm
- Enterobiasis
- Hookworm = nematode
- Strongyloidiasis
- Cestodiasis
Term
What diseases are ectoparasitic infestations?
Definition
Head and body lice
Term
What is giardiasis?
Definition
Caused by giardia lamblia - most common intestinal parasite that causes diarrhea. Cysts --> trophozoites --> diarrhea, bloating, anorexia
Term
How is giardiasis treated?
Definition
- Adults: First line - metronidazole, tindazole, or nitazoxanide
- Children over 8 - drug of choice is quinacrine, but must be compounded. Nitazoxanide can be used in all ages
Term
What is amebiasis?
Definition
Caused by Entamoeba histolytica - cyst ingested, morphs into trophozoites
- Bloody diarrhea in 100% of cases, can cause an abcess leading to high fever, sweating, signs of infection
Term
How is amebiasis diagnosed and treated?
Definition
- Cysts found in stool by ELISA
- asymptomatic and mild - paromomycin (preferred in pregnancy), iodoquinol, or doloxanide.
- Severe or intestinal abscess - Metronidazole x10 days followed by an above luminal agent. Use TINDAZOLE in a liver abscess
**Repeat tests at days 5,7,and 1 month. Sanitation!
Term
What is used to treat hookworms and Ascariasis?
Definition
Mebendazole/Albendazole
Term
How is enterobiasis treated?
Definition
Pyrantel pamoate 11 mg/kg (max: 1g) x 1 dose
Mebendazole 100 mg x 1 dose
Albendazole 400 mg x 1 dose
**Usually children
Term
How is strongyloidiasis treated?
Definition
Ivermectin is drug of choice, can use albendazole as alternative
Term
Are drugs used to treat tapeworms?
Definition
Normally not
- Do not treat cystercosis
- Tx controversial of neurocystercosis - albendazole
Term
What are the 4 reasons people die of malaria?
Definition
- Failure to prophylax
- Inappropriate prophylaxis
- Delay in seeking medical care
- Misdiagnosis
Term
What is the use of primaquine in malaria?
Definition
For Chloroquine-RESISTANT P. vivax
Term
What drug is used in severe malaria if quinidine is not available?
Definition
Artesunate - comes from the CDC. + Atovaquone-proquanil OR Doxy/Clinda OR mefloquine
Term
When would mefloquine not be used?
Definition
Malaria is becoming resistant in SE asia --> Atovaquone or Doxy
Term
What are the complications due to P. falciparum?
Definition
- Pulmonary edema
- Hypoglycemia
- Jaundice
- Renal failure
- Confusion, delerium, seizures, coma, death
Term
How is Chagas diseas treated?
Definition
Nifurtimox/Lampit and Benznidazole/Rochagan. A higher dose is used in children as it is more tolerable.
Term
What are the treatments for ectoparasites: lice and scabies?
Definition
- Lice: permethrin 1%/Nix
- Scabies: Permethrin 5% cream, leave on for 8-14 hours
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