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Paramyxoviridae
VM 607 Final
24
Veterinary Medicine
Professional
03/01/2012

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Term
Parmyxoviridae Characteristics
Definition
enveloped, pleomorophic, large
heat, acid, and lipid sensitive
ssRNA, negative sense
VAP is hemagglutinin-neuraminidase
fusion (F) protein allows for pathogenesis
Term
Parmyxoviridae Entry, Replication, Release
Definition
via F (fusion) protein
replicates in cytoplasm
release by budding
Term
Parmyxoviridae Tropism
Definition
respiratory epithelium
GI epithelium
neurons
Term
Parmyxoviridae Pathogenesis
Definition
damage to respiratory epithelium and mucociliary apparatus
synctial formation causes cellular dysfunciton
neuronal cell death in some viruses
Term
Parmyxoviridae Transmission
Definition
respiratory, orofecal route
transovarian in avian
Term
Newcastle Disease Characteristics
Definition
Reportable avian disease
zoonotic (mild flu disease in humans)
Term
Newcastle Disease Signs
Definition
high mortality
decreased weight gain
decreased egg production
Term
Newcastle Disease Tropism
Definition
pneumotropic
enterotropic
neurotropic
viscerotropic
Term
Newcastle Disease Pneumotropic Strains/Signs
Definition
lentogenic strain-subclinical to mild respiratory disease
mesogenic strain-respiratory disease with low mortality
Term
Newcastle Disease Enterotropic Strains/Signs
Definition
velogenic strain-virulent
severe GI disease and possibly respiratory tract involved
Term
Newcastle Disease Neurotropic Strains/Signs
Definition
all strains if the animal survives long enough
reflects chronic infection
Term
Newcastle Disease Viscerotropic Signs
Definition
exotic Newcastle Disease
affect internal organs
Term
Newcastle Disease Pathogenesis
Definition
primary replication in mucosal epithelium
Viremia and systemic spread
Secondary replication in visceral organ
Secondary viremia enters CNS
Term
Newcastle Disease Transmission
Definition
respiratory, orofecal route
transovarian
Term
Newcastle Disease Control
Definition
MLV lentogenic strain
sanitation
control black market birds
Term
Bovine Parainfluenza Signs
Definition
acute respiratory infection
mild to subclinical
Term
Bovine Parainfluenza Characteristics
Definition
part of the enzootic pneumonia/shipping fever complex
Term
Bovine Parainfluenza Control
Definition
bovine PI-3 vaccine
Term
Canine Distemper Signs
Definition
acute generalized disease
must differentiate between CAV-1
pulmonary form
enteric form
neurological form - bubblegum seizures, grand mal seizures, paralysis and death within 1 month
hard pad disease-hyperkeratosis footpad and nasal epithelium
Term
Canine Distemper Pathogenesis
Definition
primary replication in respiratory epithelium, macrophages, bronchial lymph nodes, pharyngeal lymph nodes, GI tract
cell associated viremia in macrophages, monocytes, lymphocytes in 7-14 days
pantropic infection including CNS
immunodeficiency, hypogammaglobulinemia
Term
Canine Distemper Transmission
Definition
secretions, excretions, wildlife reservoirs
Term
Canine Distemper Control
Definition
measles virus vaccine
MLV vaccine
Term
Bovine Respiratory Synctial Virus Characteristics
Definition
affects cattle and sheep
very labile virus
enzootic
Term
Bovine Respiratory Synctial Virus Signs
Definition
mild to severe respiratory disease
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