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Paramedic Magnesium Sulfate
Mag sulfate drug profile
12
Pharmacology
Not Applicable
10/18/2012

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Cards

Term
Class
Definition
Antidysrhythmic
Anticonvulsant
CNS depressant
Term
Mechanism of Action
Definition
Antidysrhythmic properties-Physiological calcium channel blocker. Reduces SA node impulse formation, prolongs conduction time in myocardium
Anticonvulsant properties-reduces striated muscle contractions and blocks peripheral neuromuscular transmission by reducing acetylcholine release at the myoneural junction
Term
Indications
Definition
Polymorphic V-tach associated with Torsades
Seizure prevention and control in preeclampsia and eclampsia (trx of choice)
Suspected hypomagnesemia
Status asthmatics not responsive to beta agonists or anticholinergics
Term
Contraindications
Definition
Heart Block
MI
Hypermagnesemia
Term
Precautions
Definition
Renal insufficiency
Term
Available Forms
Definition
500 mg/mL, in 2 mL and 10mL vials
Term
Adult Dosages
Definition
Polymorphic V-tach with Torsades= 1-2g IV in 20cc NS every 5 minutes, give no faster than 1 gram/minute
OB seizures= same as Torsades. Maintenance infusion= 5g/250 cc or 2g/100cc buretrol, run at 100cc/hr
Status Asthmaticus= 2 g IV diluted in 20cc NS no faster than 1g/min
Term
Onset
Definition
IV-immediate
Term
Duration
Definition
IV-30-60 minutes
Term
Side Effects
Definition
Flushing/sweating
Itching/ Rash
Hypothermia
Drowsiness
Respiratory depression
Bradycardia
AV block
Flaccid paralysis
Absence of knee jerk
Hypotension, diaphoresis
Term
Indications
Definition
Incompatible with alcohol, salicylates, sodium bicarb
Additive effects can occur with other CNS depressants
Concurrent use with nifedipine in the trx of maternal hypertension can cause increased hypotension or pronounced muscle weakness and may harm the fetus
Can cause cardiac conduction abnormalities when used in conjunction with cardiac glycosides
Term
PEARLS
Definition
As a smooth muscle relaxant, it's an effective 2nd or 3rd line intervention in cases of severe, refractory bronchospasm
Use aggressively in the setting of eclampsia, it's IS THE PREFERRED TRX
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