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Antidysrhythmic Anticonvulsant CNS depressant |
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Antidysrhythmic properties-Physiological calcium channel blocker. Reduces SA node impulse formation, prolongs conduction time in myocardium Anticonvulsant properties-reduces striated muscle contractions and blocks peripheral neuromuscular transmission by reducing acetylcholine release at the myoneural junction |
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Definition
Polymorphic V-tach associated with Torsades Seizure prevention and control in preeclampsia and eclampsia (trx of choice) Suspected hypomagnesemia Status asthmatics not responsive to beta agonists or anticholinergics |
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Heart Block MI Hypermagnesemia |
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500 mg/mL, in 2 mL and 10mL vials |
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Polymorphic V-tach with Torsades= 1-2g IV in 20cc NS every 5 minutes, give no faster than 1 gram/minute OB seizures= same as Torsades. Maintenance infusion= 5g/250 cc or 2g/100cc buretrol, run at 100cc/hr Status Asthmaticus= 2 g IV diluted in 20cc NS no faster than 1g/min |
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Flushing/sweating Itching/ Rash Hypothermia Drowsiness Respiratory depression Bradycardia AV block Flaccid paralysis Absence of knee jerk Hypotension, diaphoresis |
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Definition
Incompatible with alcohol, salicylates, sodium bicarb Additive effects can occur with other CNS depressants Concurrent use with nifedipine in the trx of maternal hypertension can cause increased hypotension or pronounced muscle weakness and may harm the fetus Can cause cardiac conduction abnormalities when used in conjunction with cardiac glycosides |
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Definition
As a smooth muscle relaxant, it's an effective 2nd or 3rd line intervention in cases of severe, refractory bronchospasm Use aggressively in the setting of eclampsia, it's IS THE PREFERRED TRX |
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