Term
Trade Name for Streptokinase |
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Definition
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Term
Streptokinase--drug class |
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Definition
Fibrinolytic (thrombolytic enzyme) |
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Term
Streptokinase--Mechanism of Action |
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Definition
Converts plasminogen to plasmin, which aids in the dissolution of blood clots. |
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Term
Streptokinase--Contraindications |
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Definition
-Active internal bleeding -Cerebrovascular accident w/in 2 mos -Intracranial or intraspinal surgery -Severe, uncontrolled HTN (syst > 180, diast > 110) -Significant trauma (sp. head) -Prolonged CPR |
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Term
Streptokinase--Indications |
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Definition
-AMI -Pulmonary Embolism -DVT (deep venous thrombosis) -Arterial Thrombosis -Embolism |
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Term
Streptokinase--Precautions |
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Definition
-May cause severe bleeding -Use one IV line exclusively for admin |
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Term
Streptokinase--Available Forms |
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Definition
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Term
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Definition
-AMI, infuse 1.5 mil units/45 mL w/in 60 mins -Embolism/Thrombosis, admin loading dose of 250,000 units via IV into a peripheral vein over 30 min |
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Term
How does streptokinase come prepared? |
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Definition
250,000 or 750,000 or 1.5 million units powder in a vial that must be reconstituted |
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Term
How is streptokinase administered? |
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Definition
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Term
Pediatric dosage of streptokinase. |
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Definition
Safety in pediatric Pts has not been established. |
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Term
Side-effects of streptokinase. |
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Definition
-Bleeding -Allergic rxn -HypoTN -Chest pain -Reperfusion dysrhythmias -Abdominal pain |
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Term
Streptokinase interacts with... |
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Definition
-Anticoagulants -Agents that alter platelet fxn (aspirin, NSAIDs) -Thrombolytic agents -Agents that alter coagulation |
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Term
Trade name for t-PA (altepase). |
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Definition
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Term
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Definition
Same as streptokinase, converts plasminogen to plasmin. |
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Term
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Definition
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Term
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Definition
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Term
Indications for t-PA admin. |
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Definition
-Acute ischemic stroke -AMI caused by occlusion -Pulmonary thrombosis/embolism |
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Term
Contraindications for t-PA admin. |
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Definition
-Intracranial hemorrhage or Hx thereof -Recent intraspinal or intracranial surgery -Serious head trauma -Previous stroke -Hx of severe HTN -Seizure w/ stroke -Active internal bleed -Trauma surgery w/in 10 days -Pt > 75 y/o |
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Term
Precaution of t-PA admin. |
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Definition
Recommended min. of 3 patent IV sites prior to admin |
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Term
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Definition
One vial powder to be reconstituted with one vial sterile water. |
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Term
How does t-PA come prepared? |
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Definition
100 mg, 50 mg, or 2 mg/vial |
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Term
How is t-PA administered? |
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Definition
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Term
What is the adult dosage of t-PA for cardiac problems? |
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Definition
0.9 mg/kg infused over 60 min w/ 10% of total dose pushed as an IV bolus over 1 min (MTD 100 mg). |
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Term
What is the adult dosage of t-PA for suspected CVA? |
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Definition
15 mg IV bolus, followed by 0.75 mg/kg infusion over 30 min |
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Term
What is the ped dosage of t-PA? |
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Definition
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Term
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Definition
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Term
What are the side effects of t-PA? |
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Definition
-HypoTN -Bleeding -Fever -NV -Easy bruising/bleeding |
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Term
What are the signs of t-PA toxicity? |
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Definition
-Syncope -Vision changes -Coughing/vomiting blood -Slurred speech |
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Term
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Definition
Do not use with other anticoagulants (ex. Warfarin, Aspirin, etc.) |
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Term
This is the generic name for aspirin. |
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Definition
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Term
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Definition
Prevents the formation of thromboxane and inhibits the production of prostaglandins. |
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Term
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Definition
-Antiplatelet (inhibits the production of thromboxane) -Analgesic (blocks the synthesis of prostaglandins and prevents sensitization of pain receptors) -Antipyretic (lowers temp via vasodilation) |
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Term
What are the indications of aspirin admin? |
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Definition
-Ischemic chest pain -Stroke (?) |
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Term
Contraindications of aspirin admin. |
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Definition
-Reye's -Pt w/ GI bleed -Alcoholics -Hemophilia -Nose polyps -VonWillebrand's -Breast feeding -Blood clotting disorders |
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Term
What are the precautions of aspirin admin? |
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Definition
Lethal dose achieved at 400 mg/kg |
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Term
Aspirin is available in what forms? |
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Definition
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Term
What is the adult dosage of aspirin for ischemic chest pain? |
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Definition
324 mg, chewed and swallowed |
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Term
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Definition
15-30 min after ingestion |
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Term
Side effects of aspirin admin? |
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Definition
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Term
What are the signs of aspirin toxicity? |
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Definition
-"Classic" signs are tachycardia, febrile, and tachypnea -Hepatotoxicity -Anemia -Forms concentrations in the stomach |
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Term
What is the generic name of nitroglycerine? |
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Definition
Nitrostat, Tridil (IV form) |
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Term
Nitro is what class of drugs? |
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Definition
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Term
What is the site of action of Nitro? |
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Definition
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Term
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Definition
Breaks down Nitric Oxide (NO) |
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Term
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Definition
-Relaxes smooth muscle -Decreases preload/afterload -Dilates coronary arteries |
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Term
Indications for nitro admin. |
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Definition
-Ischemic chest pain -Pulmonary edema (incl. CHF) -HTN crisis |
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Term
Contraindications of nitro admin. |
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Definition
-HypoTN -Bradycardia -ED drugs w/in 24 hr |
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Term
Precautions of nitro admin. |
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Definition
Pt w. inferior (R. sided) AMI |
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Term
Nitro is available in what forms? |
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Definition
Spray, tablet, solution, paste |
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Term
How does nitro come prepared? |
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Definition
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Term
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Definition
Sublingual, oral, IV, topical |
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Term
What is the adult dosage of nitro for chest pain? |
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Definition
0.4 mg sublingual, q 5 min (as long as systolic stays > 90 mm Hg) |
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Term
What is the adult dosage of nitro for edema? |
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Definition
0.4-0.16 mg sublingual q 5 min (as long as diastolic stays > 100 mm Hg) |
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Term
What is the pediatric dosage of nitro? |
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Definition
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Term
What is the onset, and peak effect of nitro? |
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Definition
1-4 min onset, 8 min peak |
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Term
What are the side-effects of nitro admin? |
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Definition
-HA -HypoTN -Reflex tachycardia |
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Term
If you admin nitro, and the Pt complains of a throbbing headache, it means... |
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Definition
The Pt has received a therapeutic level of nitro (no more is needed). |
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Term
What is the sign of Nitro toxicity? |
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Definition
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Term
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Definition
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Term
What is the adult dosage of morphine for pain? |
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Definition
2-4 mg slow IV over 1-5 min every 5-30 min, titrate to effect |
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Term
What is the adult dosage of morphine for STEMI? |
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Definition
2-4 mg IV, may give additional doses at 2-8 mg @ 15 min intervals |
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Term
What is the adult dosage of morphine for NSTEMI? |
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Definition
1-5 mg IV, only if symptoms are not relieved by nitrates, or if symptoms reoccur. |
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Term
What is the pediatric dosage of morphine? |
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Definition
0.1-0.2 mg/kg IV, MTD 15 mg |
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Term
What is the trade name for adenosine? |
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Definition
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Term
Adenosine belongs to what class of meds? |
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Definition
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Term
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Definition
• Slows tachycardias associated with AV node via modulation of the autonomic NS • Slows conduction through the AV node, and blocks reentry pathways |
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Term
Indications for adenosine use. |
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Definition
• SVTs (including WPW) refractory to vagal maneuvers • Stable monomorphic wide complex tachycardia |
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Term
Contraindications for adenosine use. |
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Definition
• 2nd or 3rd Degree HB • Sick sinus syndrome • Known AFib/AFlut (won’t harm, but won’t fix) • Irregular wide-complex tachycardias |
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Term
Precautions for adenosine use. |
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Definition
May cause refractory bronchospasm (so use cautiously in COPD and asthma Pts) |
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Term
How does adenosine come prepared? |
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Definition
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Term
What is the adult dosage of adenosine? |
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Definition
6 mg rapid IV bolus followed by 20 mL flush and extremity elevation. |
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Term
How may adenosine be readministered? |
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Definition
If no response in 1-2 min to initial bolus, admin 12 mg. |
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Term
What is the onset of adenosine? |
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Definition
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Term
What is the duration of adenosine? |
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Definition
10 sec (so must administer very quickly, usually simultaneously with partner pushing NS flush) |
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Term
What are the side effects of adenosine? |
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Definition
• Flushing • Chest pain • Dyspnea • HA • Diaphoresis • Metallic taste • Dizziness • Lightheadedness • Numbness • NV • Palpitations |
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Term
What are the interactions of adenosine? |
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Definition
• Additive effects—digoxin, CBBs • Antagonistic effects--methylxanthines |
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Term
What are the special considerations of adenosine admin? |
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Definition
• Consider having partner admin flush for speed purposes • Admin very rapidly • Have EKG printout going before and during push |
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Term
Adenosine should be administered for... |
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Definition
-SVTs (incl. WPW) -Monomorphic Wide Complex Tachycardia |
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Term
Trade name for amiodarone. |
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Definition
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Term
Drug class of amiodarone. |
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Definition
Antiarrhythmic (Class III) |
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Term
Indications for amiodarone admin. |
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Definition
• Recurrent VFib • Sustained VTach • Refractory VTach/VFib |
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Term
Contraindications for amiodarone. |
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Definition
• HypoTN • Cardiogenic Shock • Bradycardia • 2nd or 3rd Degree HB • Do not use w/ drugs that prolong QT intervals |
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Term
How does amiodarone come prepared? |
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Definition
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Term
How is amiodarone administered? |
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Definition
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Term
What is the adult dosage of admiodarone for cardiac arrest? |
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Definition
300 mg/20-30 mL NS, readmin 150 mg @ 3-5 min with MTD 450 mg |
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Term
What is the adult dosage of admiodarone for VTach/VFib? |
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Definition
150 mg over 10-15 min, q @ 10 min |
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Term
What is the onset of amiodarone? |
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Definition
5-15 min, peaks at 30-45 min |
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Term
What is the duration of amiodarone? |
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Definition
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Term
What are the side-effects of amiodarone admin? |
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Definition
• Vasodilation • Hepatoxicity • HypoTN • Prolonged QT • Bradycardia • VTach/VFib • Heart blocks |
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Term
What are the interaction concerns of amiodarone admin? |
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Definition
• May increase Digoxin levels and lead to Digoxin toxicity • May cause HypoTN, bradycardia, and decreased CO when concurrently used with Fentanyl |
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Term
What is the trade name of atropine sulfate? |
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Definition
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Term
What classes of drugs does atropine belong to? |
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Definition
• Anticholinergic • Parasympatholytic • Antimuscarinic |
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Term
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Definition
• Inhibits ACh at postganglionic sites in smooth muscle • Blocks vagal nerve stimulation (vagalytic) |
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Term
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Definition
• Increase HR • Decrease GI and respiratory secretions |
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Term
What are the indications for atropine admin? |
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Definition
• Symptomatic sinus bradycardia • Low-degree HB (1st Degree/2nd Degree Type I) • Pesticide poisoning (organophosphates) |
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Term
What are the contraindications for atropine admin? |
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Definition
• NAG • Acute hemorrhage • Tachycardia • Destructive disease of the GI |
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Term
What are the precautions of atropine admin? |
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Definition
• Intra-abdominal infections • Lactation • Infants w/ Down Syndrome |
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Term
Atropine comes in what forms? |
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Definition
PFS, vial, ampule and autoinjector |
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Term
How does atropine come prepared? |
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Definition
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Term
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Definition
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Term
What is the adult dosage of atropine for bradycardia? |
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Definition
0.5 to 1 mg, q @ 3-5 min, MTD 3 mg |
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Term
What is the adult dosage of atropine for poison? |
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Definition
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Term
What is the onset of atropine? |
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Definition
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Term
What is the duration of atropine? |
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Definition
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Term
Atropine admin side-effects: |
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Definition
• Drowsiness • Confusion • Blurred vision • Tachycardia • Heart palpitations • Dry mouth • Constipation • Urinary hesitancy • Pulmonary edema • Flushing/decreased sweating |
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Term
What are the interaction concerns of atropine? |
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Definition
May alter the absorption of orally administered drugs by slowing the motility of the GI tract. |
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Term
What is the trade name of diltiazem? |
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Definition
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Term
What class of drug does diltiazem belong to? |
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Definition
Class IV Antiarrythmic (Ca++ Blocker) |
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Term
What are the actions of diltiazem? |
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Definition
• Arterial Vasodilator • Negative dromotrope |
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Term
Indications for diltiazem admin: |
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Definition
• AFib and AFlut • MAT • PSVT (2nd line) |
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Term
Contraindications for diltiazem admin: |
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Definition
• HypoTN • Sick sinus syndrome • WPW • VTach • AMI • 2nd and 3rd Degree HB |
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Term
Diltiazem is available in what form? |
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Definition
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Term
How does diltiazem come prepared? |
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Definition
25 mg/5 mL and 50 mg/10 mL |
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Term
What is the adult dosage of diltiazem? |
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Definition
10 mg over 2 min, q @ 10-15 min |
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Term
What is the onset of diltiazem? |
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Definition
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Term
What is the duration of diltiazem? |
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Definition
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Term
Side-effects of diltiazem admin: |
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Definition
• 1st and 2nd Degree HB • Bradycardia • Ventricular dysrhythmias • HypoTN • Syncope • Flushing • Chest pain |
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Term
What are the interaction concerns of diltiazem? |
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Definition
• Potentiates Versed, ASA • Don’t combine w/ B-blockers or Lasix |
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Term
What are the special considerations of Tx a Pt with diltiazem? |
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Definition
• Shelf life of approx. 30 days (so rarely carried prehosp) • In general, a Pt with Afib will rarely be Tx (preference is cardioversion or transport for Dr review) |
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Term
What are the trade names of dopamine hydrochloride? |
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Definition
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Term
What class of drugs does dopamine belong to? |
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Definition
Inotrope (adrenergic dopaminergic catecholamine sympathomimetic) |
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Term
Where is the site of action for dopamine? |
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Definition
Naturally occurring catecholamine that is the chem precursor of NE. |
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Term
What are the indications of dopamine? |
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Definition
• Cardiogenic shock • Cardiogenic shock with pulmonary edema (CHF) • Hypovolemic shock/HypoTN (after fluid resuscitation) • Neurogenic shock • Septic shock • Refractory symptomatic bradycardia • HypoTN after ROSC (return of spontaneous circulation) |
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Term
What are the contraindications of dopamine admin? |
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Definition
• Hypovolemic shock • Pheocromocytoma • Tachydysrhythmias • Women on oxytocin • VFib/VTach |
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Term
What are the precautions of dopamine admin? |
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Definition
• Have two lines, one for dopamine, other for other drugs • DO NOT MIX DOPAMINE AND SODIUM BICARB!!! |
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Term
Dopamine is available in what forms? |
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Definition
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Term
How does dopamine come prepared? |
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Definition
200, 400, or 800 mg in 5 mL |
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Term
What are the dose specific actions of dopamine? |
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Definition
Dose dependent actions of Dopamine • 1-2 mcg/kg/min—increases renal blood flow • 2-10 mcg/kg/min—inotropic and chronotropic effects as stimulate B1 receptors (below 5 mcg will still get renal effects) • 10-20 mcg/kg/min—vasoconstriction of renal and peripheral arteries/veins via stimulation of B1 and A receptors • >20 mcg/kg/min—mimics NE’s pure alpha effects |
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Term
What's the adult dosage of dopamine? |
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Definition
• 2-20 mcg/kg/min; not to exceed 20 mcg/kg/min w/o med direction. Generally start at 5-10 mcg/kg/min. |
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Term
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Definition
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Term
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Definition
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Term
What are the side-effects of dopamine admin? |
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Definition
• Dysrhythmias • HTN • HA • NV • Dizziness • Ectopy • Bradycardia • Tremors • Angina, AMI • Pain • Tachycardia incl. VTach/VFib |
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Term
What are the signs of dopamine toxicity? |
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Definition
• Tachycardia • Dysrhythmias |
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Term
What are the interaction concerns of dopamine? |
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Definition
TCAs, MAOIs, bretylium, precipitates alkaline solutions (sodium bicarb) |
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Term
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Definition
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Term
What drug class does epinephrine belong to? |
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Definition
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Term
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Definition
• Alpha 1—constricts blood vessels, smooth muscles, stimulates glucose production, and decreases GI venous supply • Beta 1—Heart, stimulates SA node and L ventricle • Beta 2—Lungs, relaxes smooth muscle of the lungs, blood vessels, uterus and cerebellum |
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Term
What are the actions of epi? |
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Definition
• Constricts blood vessels • Increases HR • Increases heart contractility • Decreases GI blood supply • Counteracts histamine • Dilates bronchioles |
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Term
What are the indications for epi admin? |
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Definition
• Anaphylaxis/Allergic rxn • Bronchial asthma • Cardiac arrest • Pediatric symptomatic bradycardia • Severe hypoTN w/ bradycardia when Atropine/pacing fail (secondary med) • Croup |
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Term
What are the contraindications of epi admin? |
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Definition
• None in cardiac arrest or life-threatening situations • Lower dose or admin slowly in Pts w/ heart disease • Hypovolemic shock |
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Term
What are the precautions of epi admin? |
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Definition
• MAOI may potentiate effects • May be deactivated by sodium bicarb (so flush line before admin Epi) • Do not use PFS for Epi infusions • Syncope in asthmatic children can occur • Have EKG and IV in place |
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Term
Epi is available in what forms? |
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Definition
PFS, vials, and auto-injectors |
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Term
How does epi come prepared? |
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Definition
•Vials—1 mg/1 mL (1:1,000) or 1 mg/10 mL (1:10,000) •Auto-injector—0.3 mg/mL (1:2,000) for adult, 0.15 mg/mL for peds |
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Term
What are the routes of epi admin? |
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Definition
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Term
What are the proper doses of epi? |
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Definition
Severe Bradycardia/HypoTN (extremely rare except w/ peds) • Adult—2-5 mcg/min infusion titrated to response
Pulseless Arrest • Adult—1 mg (1:10,000) IV/IO push diluted in 10 mL, rpt 3-5 min
Anaphylactic Arrest • Adult—(mild) 0.3-0.5 mg (1:1,000) IM/SQ, q 15 min; (severe) 0.3-0.5 mg (1:10,000) slow IV over 5 min
Croup • 0.25-0.5 mL of a 2.25% solution |
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Term
What is the onset of epi? |
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Definition
SQ/IM 5-10 min IV/ETT 1-2 min |
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Term
What is the duration of epi? |
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Definition
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Term
What are special considerations relative to epi dosing and admin route? |
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Definition
SQ/IM use 1:1,000 IV/ETT use 1:10,000 |
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Term
What is the trade name of lidocaine hydrochloride? |
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Definition
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Term
Lidocaine belongs to what class of drugs? |
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Definition
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Term
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Definition
Depresses the action potential of purkinje fibers. |
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Term
What are the actions of lidocaine? |
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Definition
• Increases the ventricular threshold (increases refractory period of cells) • Blocks fast Na+ channels • Decreases Phase 4 depolarization |
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Term
What are the indications for lidocaine admin? |
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Definition
• Stable monomorphic VTach w/ pulse • Pulseless VTach/VFib • Prophylactic for ICP pre-RSI • PVCs (currently not recommended) |
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Term
What are the contraindications of lidocaine admin? |
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Definition
• Advanced AV blocks • IVR/Bradycardia • Adam-Stokes Syndrome • HypoTN • WPW |
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Term
What are the precautions of lidocaine admin? |
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Definition
Cut maintenance dose in half if they are heptic impaired, in shock, or in heart failure. |
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Term
How does lidocaine come prepared? |
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Definition
• 2% (100 mg/5 mL), PFS • 20% (1 g/5 mL), pre-mixed solution for maintenance dose • 1 g/250 mL, maintenance mixture |
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Term
What are the routes of lidocaine admin? |
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Definition
• IV, IO, IM, ETT (1 of 4, LEAN) • Remember with ETT, dose is 2-2.5x normal dose (but still equates to single IV dose) |
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Term
What are the four drugs that can be administered via ETT? |
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Definition
Lidocaine, Epi, Atropine, Narcan |
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Term
What are the adult doses of lidocaine? |
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Definition
• Cardiac Arrest—1 or 1.5 mg/kg (usually 1.5 mg), q 3-5 min, MTD 3 mg/kg (so typically admin’d 2x) • Maintenance Dose—1 g/250 mL NS (4 mg/mL), @ 2-4 mg/min (rd up total Bolus dose to next whole number for maintenance dose) o Only hang maintenance dose if rhythm converted • Vent. Ectopy/Wide Complex Tachycardia—intial dose 1 or 1.5 mg/kg, with MTD 3 mg/kg, and rpt doses half initial dose |
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Term
What is the onset of lidocaine? |
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Definition
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Term
What is the duration of lidocaine? |
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Definition
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Term
What are the side effects of lidocaine admin? |
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Definition
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Term
What are the signs of lidocaine toxicity? |
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Definition
• Seizure • Tinnitus • Fasciculation • Slurred speech • ALOC |
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Term
What are the interaction concerns of lidocaine admin? |
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Definition
Added cardiac depression when used concurrently with amiodarone, procainamide, and B-Blockers |
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Term
What is the trade name of vasopressin? |
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Definition
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Term
What class of drugs does vasopressin belong too? |
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Definition
Antidiuretic hormone (naturally occurring in the body...ADH) |
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Term
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Definition
• Vasoconstrictor w/o inotropic or chronotropic effects and a smooth muscle stimulator in the GI tract |
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Term
Vasopressin is indicated for the Tx of... |
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Definition
Cardiac Arrest (and diabetes insipidus) |
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Term
What are the contraindications of vasopressin admin? |
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Definition
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Term
What are the precautions of vasopressin? |
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Definition
• Migraine • Epilepsy • CHF • CAD • Asthma |
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Term
Vasopressin is available in what form? |
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Definition
Vial (5 units/mL or 20 units/mL) |
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Term
Vasopressin is admin'd via what route? |
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Definition
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Term
What is the adult dosage of vasopressin? |
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Definition
40 units in one single dose |
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Term
The onset of vasopressin is... |
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Definition
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Term
What's the duration of vasopressin? |
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Definition
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Term
What are the side-fx of vasopressin? |
|
Definition
Post resuscitation, may see: o Ischemic chest pain o ABD distress o NV o Bronchial constriction o Tremors o Sweating |
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Term
What are the interaction concerns of vasopressin? |
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Definition
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|
Term
In what way can vasopressin be utilized during cardiac arrest? |
|
Definition
Can be used in place of 1st and 2nd dose of epi in cardiac arrest Tx (1 dose of vasopressin = 2 doses of epi). |
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Term
What are the side effects of digoxin? |
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Definition
• HA • Weakness • Confusion • Seizures • HypoTN • NV • Skin rash • High-degree AV blocks |
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Term
What are the signs of dig-toxicity? |
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Definition
• Dysrhythmias (most commonly junctional tach) • Visual disturbances (blurred, yellow or green vision) |
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Term
What are the interaction concerns of digoxin? |
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Definition
• Amiodarone, vererpamil, and quindine may increase serum digoxin concentration by 50-70% • Erythromycin and tetracycline may increase serum digoxin levels by reducing hepatic breakdown • Diuretics may potentiate digoxin cardiotoxicity via loss of K+ |
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Term
You would use these medications to Tx ischemic chest pain. |
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Definition
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Term
You would use these drugs for the Tx of shock. |
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Definition
Epi (anaphylactic) and Dopamine (cardiogenic, hypovolemic W/ FLUID Tx, neurogenic, and septic) |
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Term
You would use these drugs to Tx symptomatic bradycardia/hypoTN. |
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Definition
Dopamine (after ROSC), atropine and epi. |
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Term
These drugs are used in cardiac arrest. |
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Definition
Epi, amiodarone, lidocaine and vasopressin. |
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Term
These drugs are used to Tx Vtach and Vfib. |
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Definition
Amiodarone and Lidocaine. |
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Term
You would use this drug in suspected pesticide (organophosphate) poisoning. |
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Definition
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Term
This drug is used to Tx SVTs and WCTs. |
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Definition
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Term
This drug is used to Tx Afib/Aflut, MAT, and PSVTs. |
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Definition
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