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Pain/Stress OC6
Patho Pain/Stress OC6
24
Pathology
Graduate
09/24/2018

Additional Pathology Flashcards

 


 

Cards

Term
Maslow's hierarchy
Definition

1. Physiological 

2. Safety

3. Love+belonging

4. Esteem

5. Self-actualization

 

Term
3 stages of Dr. Selye's General Adaptation Syndrome
Definition

1. Alarm

2. Resistance

3. Exhaustion

Term
This type of pain is poorly localized and responds well to opioids
Definition
Visceral pain (internal organs)
Term
This type of pain is well localized, sharp, throbbing, constant and repsponds well to NSAIDs
Definition
Somatic pain
Term
Sx of acute pain
Definition

Fear & anxiety

Tachycardia

Hypertension

Pupil dilation

Diaphoresis

Hyperglycemia

(decreased?) blood flow to viscera & skin

Decreased gastric acid

Term
Acute and malignant types of pain result from activation of the primary afferent nociceptors, meaning that the underlying mechanism of these types of pain is ______
Definition
Nociceptive
Term
At what point does pain become chronic?
Definition
6 months
Term
Pain threshold
Definition
Point at which pain is perceived, does not vary over time but may be affected if there is a greater stimulus in another part of the body (perceptual dominance)
Term
Pain tolerance
Definition

Point at which pt initiates a response to the pain

Very cultural

Term
Pain from damage to nerves, altered processing of pain or damage to CNS tissue
Definition
Neuropathic pain
Term
What is the main change related to aging that affects pain tx?
Definition
Kidney fx
Term
Pain meds for cancer
Definition

Fentanyl

Oxy

Dilaudid

Ketamine

Term
Tx for neuropathic pain
Definition

Anti-depressants and seizure meds:

Gabapentin (seizure med)

Cymbalta (SNRI anti-depressant)

Lyrica (expensive, highly addictive) (seizure med)

Fluoxetine (SSRI antidepressant (prozac))

 

Amitriptyline (TCA antidepressant)

Term

Gate Control Theory

What fibers transmit to the spinal cord?

What substance opens the "gate" to the brain?

What close the "gate"?

 

Definition

Delta and C fibers transmit to substantia gelatinosa to dorsal horn of cord, substance P opens gate up to brain

 

Alpha and beta close gate

Term
Effects of cortisol
Definition

Increases BG

Increases BP/CO

Anti OR Pro inflammatory

Can suppress immune system or increase humoral immunity

 

Term
How does cortisol increase BP?
Definition

Increases sensitivity of target organs to NE and Epi

Also "optimizes myocardial performance"

Term
How does cortisol increase blood glucose?
Definition

Increases free fatty acids and amino acids in blood

Increases catabolism of these compounds into glucose in liver

Decreases glucose uptake in periphery 

Term
Why would the body want to release aldosterone in a stress response?
Definition
It increases BP which increases peripheral resistance which increases perfusion
Term
What is released by the anterior pituitary in response to CRH?
Definition

Beta endorphins (analgesia)

ACTH (causes adrenal cortex to release cortisol)

GH (chronic stress lowers GH though)

Prolactin

Term
What is released by the poserior pituitary in response to CRH?
Definition
ADH
Term

This hormone largely acts on Alpha Receptors and does the following:

Releases NPY (vasoconstriction)

Increases eccrine gland production of sweat

Pupil dilation

Arteriole smooth muscle contraction

Piloerection

Definition
Norepinephrine
Term
This hormone acts largely on ___ and ____ receptors. What does it do?
Definition

Alpha and Beta receptors

Increases BP (Inc venous return, inc contractility, inc HR)

Vasodilation of Skeletal Muscle

Bronchodilation

Lipolysis (alt energy source)

Decreases insulin (keeps glucose avail for brain)

Increases glucagon (release stores of glucose)

Decreases glycogen synthesis (stop storing glucose)

Increases glycogenolysis (release stores of glucose)

Term
What changes are seen in the elderly pt with regard to pain threshold/tolerance?
Definition

Increase in pain threshold

Decrease in pain tolerance

Term
At what GFR do you use renal dosing?
Definition
GFR <50
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