Term
| How does Acetaminophen work? |
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Definition
Inhibits the synthesis of prostaglandins in the CNS and peripherally blocks pain impulse generation.
Note that IV APAP and Ibuprofen can treat more severe pain - and enable lower opioid doses. |
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Term
| Can APAP and Ibuprofen and Ketorolac be given IV? |
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Definition
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Term
| Brand name for Acetaminophen |
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Definition
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Term
| Brand name for Acetaminophen + hydrocodone? |
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Definition
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Term
| Brand name for Acetaminophen + Oxycodone |
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Definition
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Term
| Brand name for Acetaminophen + codeine |
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Definition
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Term
| Brand name for Acetaminophen + tramadol |
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Definition
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Term
| Dosage of acetaminophen for children? |
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Definition
Children < 12 y/o
10 - 15 mg/kg Q 4 - 6 hr, max 5 dosses/day. Max 5 dosses/day |
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Term
| Acetaminophen is the DOC for pain in? |
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Definition
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Term
| The difference between acetaminophen infant drops and children's suspension? |
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Definition
Infant droops (80mg/0.8 ml) are more concentrated than children's suspension (160 mg/5ml)
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Term
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Definition
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Term
| What is the dose not to exceed for Acetaminophen? |
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Definition
Do not exceed 650 mg per dose in anyone, and 4 g/day
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Term
| What is the antidote for an acetaminophen overdose/toxicity? |
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Definition
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Term
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Definition
| Statement. Not a question. |
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Term
| Can a patient drink alcohol whilst on acetaminophen? |
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Definition
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Term
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Definition
Aspirin bind irreversibly, and other NSAIDs reversibly, to cycloxygenase-1 and 2 (COX-1 and 2) enzymes, thus inhibiting prostaglandin (PG) synthesis, which are involved in pain impulse generation, and preventing formation of thromboxane A2, which decreases platelet aggregation |
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Term
| What is aspirin primarily used for? |
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Definition
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Term
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Definition
Ecotrin, Excedrin
Note: the above are actually Aspirin + APAP + caffeine |
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Term
| What is the purpose of EC (enteric-coated) tablets? |
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Definition
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Term
| All NSAIDs have risk for? |
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Definition
GI bleeding
Celecoxib has the lowest risk
Ibuprofen is relatively low - risk and has less risk than the other OTC agent naproxen |
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Term
Are NSAIDs analgesic and antipyretic, anti-inflammatory (at higher doses) |
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Definition
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Term
| When should NSAIDs be discontinued prior to elective surgery? |
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Definition
Due to antiplatelet effects, stop all NSAIDs at least a week prior to elective surgery
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Term
| Which NSAID should be avoided in children? |
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Definition
Avoid Aspirin (not other NSAIDs) in children (< 16 y/o) with any viral infection due to potential risk Reye's syndrome
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Term
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Definition
| Statement. Not a question. |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Naproxen - Esomeprazole (the PPI is used to protect the gut from damage caused by the NSAID) |
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Term
| Brand name for Diclofenac |
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Definition
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Term
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Definition
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Term
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Definition
| Statement. Not a question. |
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Term
| Which drug has the highest COX-2 selectivity |
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Definition
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Term
| Brand name for Celecoxib? |
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Definition
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Term
| Celecoxib is contraindicated with |
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Definition
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Term
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Definition
| Statement. Not a question. |
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Term
Is there every a reason to use two different NSAIDs concurrently? |
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Definition
No.
(exception: low dose aspirin for cardioprotection) |
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Term
| Can aspirin cause ototoxicity? |
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Definition
Yes. Be careful with use of aspirin and other ototoxic agents (vancomycin) |
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Term
| Should NSAIDs be taken with food? |
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Definition
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Term
| Should NSAIDs be stopped prior to elective surgery? |
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Definition
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