Term
What receptors does Benadryl block? |
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Definition
*Competitively blocks H-1 receptors |
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Term
What does Benadryl suppress? |
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Definition
*Allergic symptoms
*N/V
*Cough
*EPS |
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Term
What are some effects of Benadryl? |
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Definition
*Anti-emetic
*Sedation (keeps ventilatory drive intact)
*Hyponotic |
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Term
What drugs does Benadryl potentiate? |
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Definition
*Barbiturates
*Benzos
*Opioids |
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Term
What receptor does Cimetidine block? |
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Definition
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Term
What does H-2 antagonists do? |
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Definition
*Prevents stress ulcers
*H pylori
*More interested in side effects |
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Term
H-2 antagonist Cimetidine is an enzyme inhibitor. This results in: |
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Definition
*Reduced hepatic blood flow
*Reduced CYP450
*Helpful with high tolerance patients |
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Term
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Definition
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Term
What other neurotransmitters besides dopamine does Droperidol antagonize? |
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Definition
*Serotonin
*Norepinephrine
*GABA |
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Term
What drug is droperidol structurally related to? |
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Definition
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Term
*What %age of droperidol is protein bound? |
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Definition
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Term
What is the alpha distribution (onset) of Droperidol? |
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Definition
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Term
What is the duration of action of Droperidol? |
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Definition
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Term
How can use of Droperidol effect hemodynamics? |
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Definition
*Mild a-adrenergic effect therefore decreased ABP by peripheral vasodilatoin |
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Term
What drug was fentanyl+droperidol? |
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Definition
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Term
What are the characteristics of Innovar? |
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Definition
*Analgesia, immobility, Amnesia
*Neuroleptic analgesia
*Dissociative state similar to ketamine. |
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Term
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Definition
*Alpha 2 adrenergic agonist |
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Term
Does clonidine pass through the BBB? |
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Definition
*Yest, it is highly lipid doluble |
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Term
What advantageous effects does clonidine have? |
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Definition
*Decreases sympathetic outflow
*Analgesia effects in spinal cord |
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Term
What is the onset and DOA of clonidine? |
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Definition
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Term
What can result if a dose of clonidine is missed? |
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Definition
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Term
What can clonidine withdrawal cause? |
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Definition
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Term
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Definition
*Stimulates alpha 2 receptors in the brain, leads to decreased CO2, PVR, and BP
*Presynaptic A2 this binding decreases presynaptic calcium levels, & inhibits th release of NE. |
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Term
What is a new use for Clonidine? |
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Definition
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Term
What classification is Dexmedetomidine? |
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Definition
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Term
In comparison to Clonidine, Dexmedetomidine is ...... |
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Definition
*More selective than Clonidine |
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Term
High doses of Dexmedetomidine cause ....... |
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Definition
*Alpha One agonist stimulation |
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Term
What effect does Demedetomidine have on opioids? |
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Definition
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Term
What are some side effects of Dexmedetomidine? |
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Definition
*Bradycardia and hypotension |
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Term
What is the loading dose for Dexmedetomidine? |
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Definition
*1mcg/kg IV over 10 minutes |
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Term
What is the maintenance dose for Dexmedetomidine? |
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Definition
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Term
What is the half life of Demedetomidine? |
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Definition
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Term
|
Definition
*Phenycyclidine
*Hallucinogenic
*Stereospecific Receptors |
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Term
How does Ketamine create a dissociative anesthesia? |
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Definition
*Dissociates the thalamus from the limbic
*State of excitement and depression |
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Term
What receptors does Ketamine work at? |
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Definition
*N-methyl-D-aspartate (NMDA)
*Opioid receptors |
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Term
How is Ketamine absorbed? |
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Definition
*Skipped IV
*IM peak 10-15 minutes |
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Term
What is the distribution of Ketamine? |
|
Definition
*> lipid soluble than Thiopental, < protein
*Distribution half life 10-15 minutes
*Redistribution |
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Term
How is Ketamine metabolized? |
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Definition
*By the liver resulting in several metabolites (Norketamine)
*Enzyme inducting, tolerant |
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Term
How is Ketamine excreted? |
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Definition
*Excreted in urine after metabolism |
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Term
What hemodynamic effects does Ketamine have? |
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Definition
*Increased arterial blood pressure
*Increased HR
*Increased CO |
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Term
How does ketamine cause its hemodynamic effects? |
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Definition
*Indirect central stimulation of sympathetics
*Blocks reuptake of norepinephrine |
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Term
How does Ketamine effect the heart and lungs? |
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Definition
*Increased Pulmonary arterial pressure
*Increased myocardial work load |
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Term
In what patients should ketamine be avoided in? |
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Definition
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Term
Large doses of Ketamine are........ |
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Definition
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Term
Ketamine is beneficial in ________ shock. |
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Definition
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Term
Ketamine is excellent for asthma due to..... |
|
Definition
*Potent bronchodilator
*Upper airway reflexes intact |
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Term
What side effect of Ketamine r/t airway should the anesthetist be aware of? |
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Definition
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Term
How does ketamine affect the brain? |
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Definition
*Increased CBF
*Increased CMRO2
*Increased ICP |
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Term
What type of brain lesions should Ketamine not be used in? |
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Definition
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Term
What type of neurological side effects can Ketamine cause? |
|
Definition
*Myoclonic d/t subcortical electrical activity
*Psychotomimetic side effects |
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Term
What property does Ketamine have that other anesthetic agents lack? |
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Definition
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