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Wasting away of muscle due to disuse. |
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When a differentiated cell is replaced with another, for example: a liver cell on your face. |
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The excess growth of cells making up an organ or tissue. |
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When there is a mix for everything except atrophy |
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An increase in the mass or volume of the tissue due to enlargment of the cells that make up the organ or tissue. |
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Occurs in moist areas, line of demarcation |
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Occurs in either extreme heat or cold |
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The mast cells in one part of the body are releasing histamines |
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All of the mast cells are releasing histamines, it becomes hard to breath. |
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How to help allergic reaction? |
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Need an epipen with is a burst of adrenaline which opens the airways |
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surface barriers and internal defenses. First and second lines of attack. external body membranes,second line of defense uses antibodies, antimicrobial proteins, phagocytes, to inhibit spread of the invader; characteristic of this stage is inflammation. |
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antigens, cell-mediated immune response and humoral immune response. |
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antibody mediated; antibodies attack invaders to be destroyed by phagocytes or complement. |
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deals with lymphocytes themselves defending the body and not antibodies. Lymphocytes attack directly by lysing foreign cells or indirectly by releasing chemicals that activate other systems. |
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Provoke an immune response |
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antigens are immunogenic (can activate lymphocytes) and react with them pollen, microorganisms. |
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must hook up with the body’s own proteins to launch an attack (eg) penicillin, poison ivy; dander must hook up with body proteins to be immunogenic. |
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Class I and II happen depending on the location, and provoke an immune response |
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4 examples of alterations of immune responses |
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Allergic or hypersensitivity disorders, Autoimmune disorders,transplantation rejection, immunodeficiency states |
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Hypersensitivity reactions: Type I |
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immediate hypersensitivity disorders. Ex. Dog allergy. Mast cells attach to IgE |
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Hypersensitivity reactions: Type II |
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Cytotoxic hypersensitivity. Antibody mediated, the antibody produces the reaction. Food and drug allergy |
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Hypersensitivity reactions: Type III |
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Immune complex mediated disorders. Antibody combines with the antigen, and produces the reaction. Viral pneumonia. |
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Hypersensitivity reactions: Type IV |
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Delayed hypersensitivity. Poison Ivy. |
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When an allergic hypersensitivity affecting parts of the body not in direct contact with the allergen |
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A class of antigens which cause non-specific activation of T-cells, releasing cytokines |
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When the body recognizes its own tissues as foreign and attacks them, the condition is called autoimmunity. |
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Nerve cells, Central nervous systems. Removes the myelin sheaths. |
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Central nervous systems, attacks the receptors either by being blocked or broken. |
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A hyper thyroid condition, increases metabolism, blood pressure, lose weight, heart rate, bulging eyes |
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Type I (juvenile) diabetes mellitus |
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Definition
Pancreas is affected. Body is attacking the cells that cause insulin to decrease |
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Systemic lupus erythematosus, (SLE) |
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Definition
Mostly the kidney. Purple rash, across the chest or face. Lupis, is caused by the immune response. |
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Kidney is affected. Blood in the urine, since the strainer cannot strain, protein in the pee. |
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Affects joints and cartilage around the joints. Could test blood, and the cartilage will be gone. |
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Transplantation immunopathology |
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Definition
The cell surface antigens that determine whether transplanted tissue is recognized as foreign are the MHC or human leukocyte antigens (HLA). |
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if the donor and recipient share similar HLA types |
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if they are identical twins |
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if they are the same person |
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host versus graft disease results (HVGD) |
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If the recipient’s immune system tries to eliminate the cells bearing foreign MHC antigens |
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graft versus host disease (GVHD) |
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Definition
If the cellular immune system of the transplanted tissue attacks recipient tissue |
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Immunodeficiency disorders |
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Definition
Immunodeficiency is an abnormality in one or more branches of the immune system that renders a person susceptible to diseases normally prevented by an intact immune system. |
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Severe combined immunodeficiency (SCIDS) |
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Acquired immunodeficiency syndrome (AIDS) |
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Aids, kaposis sarcoma = AIDS. The HIV virus takes of the machinery of the body. |
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Easy for bacteria to infect the wound |
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Four signs of inflammatory response |
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Definition
Redness, pain, heat, swelling |
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