Term
| Electron Transport: NADH-Q Reductase Complex (I) |
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Definition
- Transfers electrons from NADH to Ubiquinone
- Pumps H+ to inner m. space
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Term
| Electron Transport: Cytochrome C Reductase Complex (III) |
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Definition
- Transers electrons from Ubiquinone to cytochrome c
- Pumps H+ to inner m. space
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Term
| Electron Transport: Cytochrome Oxidase Complex (IV) |
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Definition
- O2 is tightly bound between heme a3 and copper to be released only after its complete reduction to H2O by the transfer of four electrons
- Pumps H+ to inner m. space
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Term
| Electron Transport: SDH (II) |
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Definition
- Bypass the NADH-Q Reductase Complex (I) and transfers electrons from FADH2 to Ubiquinone
- Does not pump H+ to inner space
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Term
| Uncouplers of Oxidative Phosphorylation |
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Definition
- Freely diffusable across inner m. membrane
- Carry H+ from inner m. space to the matrix
- This destroys the tight coupling between electron transport and ATP synthesis
- Electrons can still flow and proton pumping is not affected but the protons move back to matrix so fast that they cannot be used to make ATP via ATP synthase (complex V)
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Term
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Definition
- Created by complex I and IV
- Formed by the partial reduction of oxygen by less than four electrons (the amount needed to make H2O)
- Highly reactive
- SOD reduces free radicals to hydrogen peroxide
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