Term
|
Definition
|
|
Term
Vancomycin is DOC for what? |
|
Definition
MRSA infections: 15 mg/kg q8 - 12 hrs |
|
|
Term
Vancomycin po (oral) is DOC for what? |
|
Definition
|
|
Term
Vancomycin time dependent or concentration dependent killing? |
|
Definition
|
|
Term
What can happen if vancomycin in infused to rapidly? |
|
Definition
Red Man Syndrome (maculopapular rash due to a too rapid infusion rate).
|
|
|
Term
What is the infusion rate for vancomycin? |
|
Definition
3o minutes for each 500mg of drug given. |
|
|
Term
Are troughs or peaks monitored for vancomycin? |
|
Definition
|
|
Term
What are the trough levels for vancomycin? |
|
Definition
pneumonia: 15 - 20 mcg/ml
Otherwise: 10-15 mcg/ml |
|
|
Term
Does vancomycin require renal adjustment? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
binds to bacterial 23S ribosomal RNA of the 50s subunit inhibiting bacterial translation and protein synthesis. |
|
|
Term
Antibiotic activity of linezolid |
|
Definition
Treats MRSA, VRE faecium and sometimes VRE faecalis |
|
|
Term
Dose adjust linezolid in renal impairment? |
|
Definition
|
|
Term
Storage of linezolid oral suspension |
|
Definition
|
|
Term
Brand name for Quinupristin and Dalfopristin |
|
Definition
|
|
Term
|
Definition
binds to different sites on the 50s bacterial ribosomal subunit inhibiting protein synthesis |
|
|
Term
Dose adjust synercid in renal impairment |
|
Definition
|
|
Term
What are the conditions for synercid to be given peripherally? |
|
Definition
Must be in a volume of 250 ml or greater (D5W only). |
|
|
Term
What is the most common side effect of Synercid? |
|
Definition
Phlebitis (40%)
Phlebitis: swelling of a vein cause by a blood clot. |
|
|
Term
Brand name for Daptomycin |
|
Definition
|
|
Term
Antibiotic activity of Daptomycin |
|
Definition
Treats MRSA, VRE faecium and faecalis |
|
|
Term
Dose adjust in renal impairment? |
|
Definition
|
|
Term
Can Cubicin be used to treat pneumonias? |
|
Definition
DO NOT USE to treat pneumonias as it is inactivate by surfactants. |
|
|
Term
Is Cubicin compatible with D5W? |
|
Definition
Compatible with NS (not D5W) |
|
|
Term
Brand name for Telavancin |
|
Definition
|
|
Term
What other drug is Telavancin related to? |
|
Definition
Vancomycin. Telavancin is a lipoglycopeptide derivative of vancomycin and so its MOA is the same - inhibits bacterial cell wall synthesis. |
|
|
Term
Antibiotic spectrum of Telavancin |
|
Definition
Active against MRSA, not VRE strains |
|
|
Term
Black Box Warning for Telavancin |
|
Definition
Fetal risk, obtain pregnancy test prior to starting therapy
|
|
|
Term
Most common side effect of Telavancin |
|
Definition
|
|
Term
Reduce dose of Telavancin in renal impairment? |
|
Definition
|
|
Term
|
Definition
Azactam - IV
Cayston - inhaled for CF |
|
|
Term
|
Definition
monbactam that inhibits bacterial cell wall synthesis by binding to PCPs |
|
|
Term
Antibiotic coverage of Aztreonam |
|
Definition
covers Pseudomonas and many gram (-) |
|
|
Term
Can it be used in PCN - allergy pts?
Dose adjust in renal impairment?
|
|
Definition
|
|