Term
| Gonadal steroid replacement |
|
Definition
dec osteoclastic activity
long term estrogen therapy |
|
|
Term
|
Definition
selective estrogen receptor modulator
no inc risk of breast/endometrial cancer
inc risk of thromboembolic disease |
|
|
Term
Bisphosphonates:
alendronate
risedronate
ibandronate
zoledronic acid |
|
Definition
inhibitors of osteoclast activity
given weekly (except ibandronate monthly)
z acid infused once yearly
inc in bone mass and dec fracture risk in postmenopausal and glucocorticoid-induced osteoporosis
rare instances of severe erosive esophagitis and osteonecrosis of jaw
don't treat for more than 5 yrs |
|
|
Term
|
Definition
osteoclast inhibitor - slows bone loss
maybe pain control for acute fracture |
|
|
Term
| Parathyroid Hormone (Teriparatide) |
|
Definition
promotes osteoblastic activity - acute elevations stimulate bone formation
daily subQ injection
only approved for two years of treatment |
|
|
Term
|
Definition
inhibits RANK ligand
given twice yearly injection |
|
|
