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osteroarthritis definition |
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Definition
wearing down of joints, especially cartilage; does not involve the immune system so you don't need to give something for inflammation |
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inhibits substance P involved in pain signaling, does not block pathway, might take few weeks to see improvement |
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recommended over oral NSAIDs with reduced risk for side effects, epensive |
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lidoderm patch; lidocane topical |
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might be useful for specific pain (ie. back pain); expensive and might not be covered |
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500mg X 6 tabs/day = 3000mg limit |
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325 X 10 tabs/day = 3250mg limit |
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650mg X 6 tabs/day = 3900mg limit |
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inhibits Cox1 (housekeeping) and Cox2 (inflammation) |
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housekeeping; involved in mucus layer production in stomach, ulceration occurs from systemic effect |
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inhibition of prostaglandins periferally; decreasing inflammation |
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Salsalate, choline-magnesium salicylates |
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non-acetylated salicylates; weaker than some NSAIDs but better SE profile |
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used to help re-build cartilage; takes time (4-6wks) |
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similar to heparin, may increase risk of bleeding |
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may increase glucose in blood, debated |
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for severe cases and can acquire tolerance, causes CONSTIPATION |
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used to lubricate the joint, used in knee as injection (medical device rather than drug) |
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Definition
may be useful for acute pain, helpful for patients with local inflammation and joint effusion; no more than every three months |
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