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oral path
chapter 2 inflammation and repair
86
Dentistry
Undergraduate 3
09/24/2014

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Term
abscess
Definition
a collection of purulent exudate that has occumulated in a cavity formed by the tissue.
Term
actinic
Definition
relating to or exhibiting chemical changes produced by radiant energy. especially the ultraviolet parts of the spectrum: relating to ultraviolet rays of sunlight.
Term
acute
Definition
disease whose duration is short or short and severe.
Term
angiogenesis
Definition

formation and differentiation of blood vessels

 

stimulates growth of new blood vessels

Term
atrophy
Definition
decrease in size of cell, tissue, organ, or whole body.
Term
central
Definition
describes a lesion in the center of an area, for oral lesions it indicates that lesion is within bone.
Term
chemotaxis
Definition
movement of WBCs as directed by chemical mediators to an area of injury.
Term
chronic
Definition
disease persists for a long period of time
Term
c-reactive protein
Definition
a nonspecific protein produced in liver that become elevated during episodes of acute inflammation or infection.
Term
cyst
Definition
an abnormal sac or cavity lined by epithelium and surrouned by fibrous connective tissue.
Term
cystolysis
Definition
dissolution or destruction of a cell.
Term
edema
Definition
excess plasma or exudate in the interstitial space that results in tissue swelling.
Term
emigration
Definition
passage of WBC through walls of small blood vessels and into injured tissue.
Term
epithelialization
Definition
process of being covered by epithelium.
Term
erythema
Definition
redness of skin or mucosa
Term
exudate
Definition
fluid with high protein content that leaves the microcirculation during and inflammatory response. an exudate consists of serum that contains white blood cells, fibrin, and other protein molecules.
Term
fever
Definition
elevation of body temp greater that 37 degrees c or 98.6 degrees f.
Term
fibroplasia
Definition
the formation of fibrous tissue as normally occurs in healing.
Term
fistula
Definition
an abnormal passage that leads to from an abscess to the body surface.
Term
granulation tissue
Definition
initial connective tissue formed in healing.
Term
granuloma
Definition
collection of macrophages surrounded by a rim of lymphocytes.
Term
hyperemia
Definition
excess of blood within vessels.
Term
hyperplasia
Definition

enlargement of tissue or organ resulting from an increase in the number of normal cells. the result of increased cell division.

 

increase in # of cells, many  cells.

Term
hypertrophy
Definition

enlargement of tissue or organ resulting from increase in size of its individual cells. but not in number of cells.

 

big cells...

Term
inflammation
Definition
nonspecific response to injury that involves the microcirculation and its blood cells.
Term
leukocytosis
Definition
temporary increase in the # of wbc circulating in blood.
Term
local
Definition

a disease process that is confined to a limited location in the body.

 

note: not general or systemic

Term
lymphadenopathy
Definition
abnormal enlargement of lymph nodes.
Term
macrophage
Definition
the second wbc to arrive at injury site, participates in phagocytosis and continues action in immune response.
Term
margination
Definition
a process during inflammation where wbc tend to move to periphery of blood vessel at site of injury.
Term
microcirculation
Definition
small blood vessels including arterioles, capillaries and venules.
Term
myofibroblast
Definition
a fibroblast that has some characteristics of smooth muscle cells. (the ability to contract)
Term
necrosis
Definition
pathogenic death of one or more cells, or a portion of tissue, or organd from irreversible damage to cells.
Term
neutrophil
Definition
1st wbc to arrive at injury site, primary cell involved in acute inflammation also called pmn.
Term
opacification
Definition
process of becoming opaque.
Term
opsonization
Definition
the enhancement of phagocytosis by a process where a pathogen is marked with opsonins (which attract phagocytes) for destruction by phagocytes.
Term
pavementing
Definition
the adherence of wbc to blood vessel walls during inflammation.
Term
peripheral
Definition

located away from center. 

 

for oral lesions peripheral means lesion is within gingival tissue or alveolar mucosa.

Term
phagocytosis
Definition
ingestion and digestion of particulate material cells.
Term
purulent
Definition
secretion containing pus
Term
radicular
Definition
pertaining to the root of a tooth.
Term
regeneration
Definition
process where injured tissue is replaced with tissue identical to that which presented before injury.
Term
repair
Definition
restoration of damaged or diseased tissues by cellular change or growth.
Term
serous
Definition
secretion having watery consistency, relating to serum.
Term
local signs of inflammation
Definition

redness, heat

 

swelling

 

pain

 

loss of normal tissue function

 

 

Term
systemic signs of inflammation
Definition

fever

 

leukocytosis

 

lymphadenopathy

 

elevated c-reactive protein

Term
systemic
Definition
pertaining to the body as a whole
Term
transudate
Definition
fluid component of blood that normally passes through the endothelial cell walls of the microcirculation.
Term
traumatic injury
Definition
disease process taht results from injury that cause tissue damage.
Term
waldyers ring
Definition
ring of lymphadic tissue formed by two palatine tonsils, pharyngeal tonsil, lingual tonsil, and intervening lymphoid tissue.
Term
innate defense
Definition
natural barriers
Term
neutrophils make up what % of white blood cells?
Definition
60-70%
Term

who is second cell to arrive an example is monocyte.

 

derived from stem cells in bone marrow.

 

phagocytosis

Definition
macrophages
Term
what 3 systems of plasma proteins circulating in blood can be biochemical mediators of inflammation>?
Definition

kinin system

 

clotting mechanism

 

complement system

Term
kinin system
Definition

 causes dilation of blood vessels at site of injury

increasing permeability of local blood vessels

induce pain

primary kinin is bradykinin

Term
clotting mechanism
Definition

blood clotting

helps stop bleeding at injury site.

important for tissue repair.

Term
complement system
Definition

cascading histimines released from mast cells

 

can cause cell death by holes in cell (cytolysis)

stimulating phagocytes by was of opsonization.

Term
what does fever do?
Definition

pyrogens (fever producers from wbc and pathogenic organgisms)

 

pyrogens release prostaglandins in hypothalamus.

Term
what type of drug may be biochemical mediator?
Definition

antiinflammatory

 

nsaids-analgesic (pain killer) effects inhibits synthesis of prostaglandins

 

acetylsalicitic acid (aspirin)

 

ibuprofin

antihistimine

 

Term
what are the 3 phases of repair process?
Definition

inflammation

 

proliferation

 

maturation

Term
healing by primary intention
Definition
clean edges are sutured to form small clot and very little granulation tissue forms. less scar tissue.
Term
secondary intention
Definition

tissue is lost so no clean edges can be sutured.

large clot forms

more granulation tissue.

 

ie healing of tooth extraction

 

normal tissue funtion reduced.

 

kehloid formation excessive scarring raised.

Term
keloid formation
Definition

scar tissue from secondary intention healing.

appears raised and extends beyond original boundaries.

darker skinned people more prone, familial tendencies.

Term
tertiary intention healing
Definition
infection occurs at site of surgical incision which was healing from primary intention. enlargement of injured area could be cause. sometimes edges may not be joined, sutured until infection is resolved.
Term
aspirin burn
Definition
placed directly on tooth and tissue will apear necrotic and white. can cause ulcer.
Term
lesions from cocaine use
Definition

midline of hard palate

 

ulcers

keratotic lesions

exophytic reactive lesions

palatal perforation

necrotic ulcers of tongue and epiglottis

Term
hematoma
Definition
occumulation of blood in tissues.
Term
traumatic neuroma
Definition
lesion caused by trauma to peripheral nerve.
Term
palisaded encapsulated neuroma PEN
Definition
benign lesion much like traumatic neuroma. mucosal nodule
Term
oral melanotic macule
Definition
flat well circumscribed brown lesion found in dark skinned individuals. cause unknown
Term
what is the most common site of smokers melanosis>
Definition
anteriior labial gingiva is most common site.
Term
mucocele
Definition
lesion that forms when a salivary gland duce is severed and mucous secretion spills into adjacent connective tissue.
Term
ranula
Definition
large looks like mucocele forms unilaterally on floor of mouth associated with sublingual and submandibular glands.  got its name from rana latin word for frog.
Term
sialoth
Definition

salivary gland stone

 

 

Term
necrotizing sialometaplasia
Definition
benign condition of salivary glands traits are swelling, pain, ulceration can be found at junction of hard and soft palate.
Term
sialadenitis
Definition

acute or chronic

 inflammation of salivary gland tissue.

Term
gingival hyperplasia
Definition
can be caused by hypertrophy it is gingival enlargement.
Term

chronic hyperplastic pulpitis

aka pulp polyp

Definition
excessive proliferation of chronically enflammed dental pulp tissue. appears as red or pink nodule of tissue that fills the cavity of the tooth.
Term
periapical abscess
Definition
purulent exudate surrounded by connective tissue containing neutrophils and lymphocytes. patient complains of severe pain.extract drainage by opening pulp chamber or extraction.
Term
periapical granuloma/dental granuloma/chronic apical periodontitis
Definition
localized mass of chronically inflamed granulation tissue that forms at the opening of the pulp canal. usually at apex of non vital tooth.
Term
residual cyst
Definition
forms when tooth is removed and all or part of radicular cyst is left behind. treat by surgical removal of cyst.
Term
idiopathic tooth resorption
Definition
cause cannot be identified for resorption of crown  or roots of teeth.
Term
internal tooth resorption
Definition
hard tissue resorption (thinner)
Term
focal sclerosing osteomyelitis/condensing osteitis
Definition

change in bone near apices of teeth that may be a low grade infection. mandibular 1st molar is most common.  sometimes mand. 2nd molar or premolars could be involved.

appears radiopaque

Term
alveolar osteitis/dry socket
Definition

post op complication of tooth extraction.usually where 3rd molar was extracted. blood clot is lost before healing takes place.

 

gentle irrigation and insertion of medicated dressing to treat.

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