oral anticoagulants

(warfarin)

action

*antagonize Vit K

*prevent synthesis of coagulation factors VII, IX, X and prothrombin

oral anticoagulants

(warfarin)

therapeutic uses

prevention of venous thrombosis in:

*clients with Afib

*clients with prosthetic heart valves

oral anticoagulants

(warfarin)

side/adverse effects

oral anticoagulants

(warfarin)

contraindications/precautions

Preg Risk Cat X

thrombocytopenia

uncontrollable bleeding

during/following surgeries or anesthesia

Vit K defic

liver disorder

alcoholism

hemophilia

dissecting aneurysm

peptic ulcer

hypertension

threatened abortion

oral anticoagulants

(warfarin)

medication/food interactions

heparin, aspirin, glucocorticoids ↑ bleeding

acetaminophen, sulfonamides, cephalosporin ↑ effects of warfarin

Vit K ↓ effects