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Opthalmic and otic drugs
Pharmacology
147
Veterinary Medicine
Not Applicable
06/28/2020

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Term
used to induce contraction of the intraocular smooth muscle (miosis), which helps to reduce intraocular pressure (IOP).
Definition
parasympathomimetics (miotics)
Term
may be used to cause miosis in the treatment of glaucoma. Veterinary ophthalmologists may also use it at the conclusion of cataract removal to prevent cases of postoperative increased IOP.
Definition
carcbachol
Term
cholinergic agonist (miotic) that is sometimes used in the treatment of canine primary glaucoma. It may be used orally as a primary treatment of neurogenic KCS in dogs because this condition does not respond to cyclosporine or tacrolimus
Definition
pilocarpine
Term
Used to reduce IOPs for up to 48 hours in dogs. Causes miosis. Generally, this drug is used to manage potential glaucoma in the eye opposite from which a diagnosis of an acute congestive crisis of primary glaucoma is made.
Definition
demercarium bromide
Term
also known as alpha2-agonists. decrease IOP. Long-term use may result in an increase in uveoscleral outflow.
Definition
sympathomimetic
Term
used to reduce aqueous humor formation. Effects are usually noted 3 to 5 hours after a single dose
Definition
apraclonidine
Term
has a longer duration of action than does apraclonidine. It reduces aqueous humor formation and increases uveoscleral outflow.
Definition
brimonidine
Term
used clinically as an intracameral injection to cause mydriasis and to prevent bleeding after intraocular surgical procedures.
Definition
epinephrine
Term
opthalmic Parasympathomimetics
Definition
carbachol

pilocarpine

demercarium bromife
Term
opthalmic sympathomimetics alpha adrenergic agonists
Definition
Apraclonidine

Brimonidine

epinephrine
Term
opthalmic Beta-adrenergic antagonists
Definition
timolol

brinzolamide

dorzolamide hcl
Term
primarily used to prevent glaucoma from developing in the contralateral eye of a dog that has primary glaucoma in one eye. The drug reduces IOP. These drugs are most useful in treating primary open-angle glaucoma and secondary glaucoma in humans
Definition
timolol
Term
reduces aqueous humor production
Definition
brinzolamide
Term
This drug is often used in the contralateral eye of a dog with primary glaucoma to prevent development of bilateral disease. It is also used for secondary glaucoma in dogs and cats because it does not affect pupil size.
Definition
dorzolamide hcl
Term
These drugs aid in reducing IOP.
Definition
beta adrenergic antagonists
Term
decrease IOP. Long-term use may result in an increase in uveoscleral outflow.
Definition
alpha2 agonists
Term
These drugs act on prostanoid receptors to lower IOP.
Definition
prostaglandins
Term
prostaglandins
Definition
lantanoprost

Bimatoprost

Travoprost

Unoprostone Isopropyl
Term
reduces IOP, especially in canine primary glaucoma cases; results are even better when this drug is combined with carbonic anhydrase inhibitors
Definition
latanoprost
Term
lowering IOP in dogs.
Definition
unoprostone isopropyl
Term
increase osmotic pressure of plasma and create a concentration gradient that will draw fluid out of the intraocular environment. These agents are systemically administered with concurrent water deprivation (4 to 6 hours) and are indicated only for acute episodes of glaucoma not maintenance
Definition
osmotic agents
Term
an anticholinergic agent that causes the sphincter of the iris and ciliary muscles to relax. This drug is mainly used to induce mydriasis and cycloplegia for diagnostic purposes.
Definition
cyclopentolate
Term
direct acting, alpha1-agonist vasoconstrictor drug that is commonly used in veterinary medicine to induce mydriasis before cataract removal. This drug can also be used to control bleeding for minor surface procedures. On administration, lasts approximately 2 to 18 hours. It can be used in the treatment of Horner's syndrome.
Definition
phenylephrine
Term
controls pain caused by corneal and/or uveal disease. It may be used to dilate the pupil for an ophthalmic examination or before ophthalmic surgery.
Definition
atropine
Term
causes mydriasis more than cycloplegic activity of the eye. has a more rapid onset of action and a shorter duration of action than atropine. This drug's effects make it useful for funduscopic examinations. In dogs, IOP does not seem to be affected
Definition
tropicamide
Term
opthalmic anti-inflammatory/ analgesic drugs
Definition
Cromolyn sodium

Lodoxamide Tromethamine

Olapatadine hcl
Term
mast cell stabilizing agent. This drug blocks the release of histamine from mast cells after antigen recognition. This drug is particularly useful in treating patients with allergic conjunctivitis and may help alleviate seasonal allergies affecting the eyes. This drug is used for treating allergies of the eyes
Definition
cromolyn sodium
Term
may be used in horses and small animal patients
Definition
lodoxamide Tromethamine
Term
This drug is used to stop the symptoms of ocular allergies.
Definition
Olapatadine hcl
Term
ocular NSAIDs
Definition
bromfenac

diclofenac sodium

flurbiprofen sodium

Ketorolac tromethamine

Nepafenac

Suprofen
Term
used after cataract removal to minimize inflammation.
Definition
bromfenac
Term
used for the treatment of uveitis. Diclofenac is the drug of choice in diabetic patients whose insulin regulation could be altered by the systemic uptake of topical corticosteroids
Definition
diclofenac sodium
Term
may be useful in the management of uveal inflammation, especially if topical steroids are also used
Definition
flurbiprofen sodium
Term
most commonly used to control surgical or nonsurgical uveitis, especially in cases with corneal bacterial infection or ulceration.
Definition
ketorolac tromethamine
Term
used in veterinary medicine to control the pain and inflammation that accompanies cataract surgery
Definition
nepafenac
Term
may be useful in the management of uveal inflammation.
Definition
suprofen
Term
ocular steroidal antiinflammatories
Definition
prednisolone

dexamethasone

betamethasone

Fluoromethalone

Loteprednol

Rimexolone
Term
This drug is typically used in the treatment of anterior uveitis
Definition
prednisolone
Term
These drugs are used for antiinflammatory purposes
Definition
dexamethasone

fluoromethalone

loteprednol
Term
Antimicrobial-steroid combination.
Definition
betamethasone
Term
ocular analgesic. is used for corneal ulcer pain relief and may also be used to lessen blepharospasms.
Definition
morphine sulfate
Term
Antimicrobial ophthalmic drugs
Definition
Amikacin Sulfate

neomycin sulfate

gentamicin sulfate

tobramycin sulfate

ocular fluoroquinolones

enrofloxacin
Term
This drug is useful in the treatment of corneal infections, as well as in treating endophthalmitis. It does not cause retinal toxic effects.
Definition
amikacin sulfate
Term
This drug is useful in treating superficial corneal ulcers or infections of the ocular surface.
Definition
neomycin sulfate
Term
This drug is most commonly used for keratitis caused by Pseudomonas aeruginosa.
Definition
gentamicin sulfate
Term
These drugs are used for bactericidal purposes. commonly used against gram-negative corneal infections that have established themselves in the eye.
Definition
fluoroquinolones
Term
misc ocular antibiotics
Definition
chloramphenicol

polymyxin B

sulfacetamide

vancomycin
Term
This is a broad-spectrum antibiotic that is able to cross the corneal barrier and gain entrance into the anterior chamber. (Very few infections, however, happen in the anterior chamber.) Generally speaking, Staphylococcus spp. and Streptococcus spp. are destroyed by it, but Pseudomonas spp. are resistant to it.
Definition
chloramphenicol
Term
This drug is a surface detergent (cationic). Its efficacy is against gram-negative organisms and can be combined with other antimicrobials with gram-positive activity.
Definition
polymyxin B
Term
his drug is useful in the treatment of conjunctivitis and superficial eye infections
Definition
sulfacetamide
Term
This drug is used in rabbits to treat methicillin-resistant Staphylococcus aureus (MRSA).
Definition
vancomycin
Term
ocular antifungals
Definition
amphotericin B

natamycin

povidone iodine

silver sulfafiazene

itraconazole
Term
This is a broad-spectrum antifungal agent (derived from Streptomyces nodosus) used to treat equine fungal keratitis.
Definition
amphotericin B
Term
This drug is used to treat fungal keratitis
Definition
natamycin
Term
This drug can be used for chemical débridement of loose epithelium in canine ulcers
Definition
povidone iodine
Term
This is a broad-spectrum antifungal agent. Is insoluble in water and must be diluted in dimethyl sulfoxide (DMSO) in order to form a solution for instillation into the eyes. This drug may be used in horses to treat fungal keratitis.
Definition
itraconazole
Term
ocular antivirals
Definition
Trifluiridine

Idoxuridine

Interferon Alpha

Acyclovir, Valacyclovir, Famciclovir, Ganciclovir, Cidofovir, and Penciclovir
Term
This drug is used to treat feline herpes virus infections of the eye. This agent may also be used to treat superficial punctate keratitis in equines, which is thought to occur due to equine herpes virus (EHV-2), which may cause problems with the cornea.
Definition
trifluiridine
Term
This drug may be used to treat herpes virus infections of the eye in cats.
Definition
idoxuiridine
Term
This drug is used to treat feline herpes viral keratitis
Definition
interferon alpha
Term
These drugs are used in the treatment of feline herpes ocular virus
Definition
Acyclovir, Valacyclovir, Famciclovir, Ganciclovir, Cidofovir, and Penciclovir
Term
These drugs are most commonly used to treat feline ocular herpes virus infections.
Definition
ocular antivirals
Term
Drugs for Keratoconjunctivitis Sicca
Definition
cyclosporine

tacrolimus

pimecrolumus
Term
a common disorder in dogs, and it is believed from recent research that the disease may be due to an immune-mediated disease process
Definition
Keratoconjunctivitis Sicca:
Term
These agents are used for dry eyes, to relieve eye irritation, and are also used during anesthetic periods when the patient's eyes remain open and tear production is reduced.
Definition
opthalmic lubricants
Term
The main purpose of these agents is to maintain the shape of the anterior chamber during cataract surgery
Definition
opthalmic irrigants
Term
These agents are used to stop the melting effect of collagenases and proteases on the cornea.
Definition
anticollagenase drugs
Term
anticollagenase agents
Definition
acetylcysteine

edetate disodium
Term
products emulsify cerumen and purulent exudate. They work by providing a surfactant, detergent, and bubbling action. Do not use these products in patients with ruptured ear drum(s).
Definition
cerumenolytic agents
Term
products are used after cleaning of the ears has occurred. These agents can be used as maintenance agents to prevent ear infections after swimming or bathing.
Definition
drying/ cleaning agents
Term
products are commonly used with other products to help heal ear infections.
Definition
antiseptic agents
Term
has antimicrobial and antibiotic potentiating activity
Definition
antibiotic potentiating agents
Term
antibiotic potentiating agent
Definition
Tromethamine-ethylenediaminetetraacetic acid (tris-EDTA)
Term
These products are used in cases of acute or chronic otitis. They help to reduce the buildup of sebaceous and apocrine gland secretion.
Definition
corticosteroids
Term
designed to treat infections caused by Staphylococcus spp. or Pseudomonas spp
Definition
antibacterials
Term
mainly used to treat Malassezia otitis and sometimes otic candidiasis.
Definition
antifungals
Term
These products are used in cases of acute and chronic otitis. They help reduce inflammation, decrease edema, tissue hyperplasia, pain, and pruritis, and to help eliminate any infectious organisms that may be present.
Definition
corticosteroids + antimicrobial
Term
designed for use inside the ears to stop otoacariasis.
Definition
antiparasitics
Term
products used to diagnose ocular problems.
Definition
Fluorescein stain

lissamine green

phenol red

rose Bengal

Schirmir tear test
Term
used to stain the patient's cornea in cases in which a corneal ulcer is suspected. The stain fluoresces, and if a corneal ulcer is present it can be observed with the use of a cobalt blue filter and a light source. check patency of nasolacrimal duct drainage
Definition
fluorescein stain
Term
used to diagnose corneal damage and to quantify tear production. This product does not sting like Rose Bengal, but interpretation requires more experience.
Definition
lissamine green
Term
used to evaluate tear production. thread is a new accurate way to measure tear production as compared with the Schirmer tear test.
Definition
phenol red
Term
used most commonly to detect the presence of viral keratitis in felines. It can also be used to evaluate corneal epithelium that may be damaged due to keratoconjunctivitis sicca (KCS).
Definition
rose bengal
Term
used clinically to measure tear production
Definition
schirmir tear test
Term
ocular anesthetics
Definition
proparicaine hcl

tetracaine hcl

benoxinate
Term
topical anesthetic used for a variety of ophthalmic procedures.
Definition
proparicaine hcl
Term
used to produce local anesthesia of short duration for ophthalmic procedures.
Definition
tetracaine hcl
Term
supplied as drops for topical anes­thesia of the eye. This drug is a human product and has not been evaluated for use in veterinary medicine.
Definition
benoxinate
Term
opthalmic agent categories
Definition
Ocular anesthetics
Parasympathomimetics
Sympathomimetic
Beta-Adrenergic Antagonists
Carbonic Anyhydrase Inhibitors
Prostaglandins
Osmotic Agents for the Treatment of Glaucoma
Mydriatic Cycloplegic Vasoconstrictors
Antiinflammatory/Analgesic Ophthalmic Agents
Nonsteroidal Anatiinflammatory Agents
Steroidal Antiinflammatory Agents
Ophthalmic Analgesics
Antimicrobial Ophthalmic Therapy
Ocular Antifungals
Ocular Antivirals
Drugs for Keratoconjunctivitis Sicca
Ocular Lubricants/Artificial Tear Products
Ophthalmic Irrigants
Anticollagenase Agents
Term
opthalmic agent categories
Definition
Ocular anesthetics
Parasympathomimetics
Sympathomimetic
Beta-Adrenergic Antagonists
Carbonic Anyhydrase Inhibitors
Prostaglandins
Osmotic Agents for the Treatment of Glaucoma
Mydriatic Cycloplegic Vasoconstrictors
Antiinflammatory/Analgesic Ophthalmic Agents
Nonsteroidal Anatiinflammatory Agents
Steroidal Antiinflammatory Agents
Ophthalmic Analgesics
Antimicrobial Ophthalmic Therapy
Ocular Antifungals
Ocular Antivirals
Drugs for Keratoconjunctivitis Sicca
Ocular Lubricants/Artificial Tear Products
Ophthalmic Irrigants
Anticollagenase Agents
Term
otic drugs categories
Definition
Ceruminolytic Agents
Cleaning/Drying Agents
Antiseptic Agents
Antibiotic Potentiating Agents
Corticosteroid Preparations
Antibacterials
Antifungals
Corticosteroid Plus Antimicrobial Preparations
Antiparasitic Preparations
Term
rose bengal adverse effects
Definition
may be toxic to the cornea and should be thoroughly flushed from the eye to prevent irritation. Hypersensitivity reactions may occur. It may also stain clothing.
Term
ocular anesthetics adverse effects
Definition
Tetracaine may be more irritating than proparacaine; it is only sometimes used in veterinary medicine. Prolonged use may cause delayed wound healing and corneal ulcers and may retard the blink reflex. Repeated use may cause development of tolerance to the drug.
Term
carbachol adverse effects
Definition
headaches, muscle spasms of accommodation, retinal detachment, and iritis (postoperatively).
Term
pilocarpine adverse effects
Definition
local irritation, miosis, decreased visual ability, inflammation of the uveal tract (especially with repeated doses), and hyphema. This drug should not be used in secondary glaucoma cases. With repeated use, it may cause vomiting, diarrhea, increased salivation, bronchiolar spasm, and pulmonary edema
Term
demarcarium bromide
Definition
Do not use in pregnant animals. Use with caution when other cholinesterase inhibitors are used. May cause ciliary muscle spasm, headache, blurred vision, local inflammation, vomiting, diarrhea, increased salivation, and cardiac effect especially when used in high doses in small breed dogs.
Term
apraclonidine contraindications
Definition
do not use in cats
Term
apoclonidine and brimonidine adverse effects
Definition
allergic conjunctivitis, eye itching, oral dryness, and visual disturbance have been noted
Term
epinephrine adverse effects
Definition
possible eye irritation at administration.
Term
timolol adverse effects
Definition
miosis in dogs and cats to a slight degree.
Term
dorzolamide adverse effects
Definition
stinging sensation in cats. Hypersensitivity may also occur.
Term
lantanoprost adverse effects
Definition
Topical irritation and hyperemia of the conjunctiva may be noted. Various other effects may also occur.
Term
unoprostone isopropyl adverse effects
Definition
may cause hyperemia of the conjunctiva
Term
cyclopentolate adverse effects
Definition
increases IOP and should never be used in animals with glaucoma.
Term
phenylephrine adverse effects
Definition
Local irritation may occur. In cats and rabbits, stromal clouding may occur if the corneal epithelium is damaged.
Term
atropine adverse effects
Definition
causes mydriasis and accommodation paralysis. Hypersalivation may occur in cats when drops are administered. can cause a decrease in tear production in small animals. In horses, repeated treatment may cause colic, although this is rare.
Term
tropicamide adverse effects
Definition
Side effects include less effective pain control than atropine; hypersalivation, especially in cats; stinging of the eye on administration; and acute congestive glaucoma in some patients.
Term
cromolyn sodium adverse effects
Definition
In humans, a stinging sensation has been reported at administration
Term
lodoxamide adverse effects
Definition
may produce a stinging sensation on administration of the drug.
Term
olopatidine contraindications
Definition
Do not use in pregnant animals.
Term
bromfenac adverse effects
Definition
hypersensitivity
Term
flurbiprofen contraindications
Definition
patients with infected corneal ulcers because this drug can be as immunosuppressive as topical corticosteroids
Term
nepafenac adverse effects
Definition
may cause bleeding of ocular tissues.
Term
all typical nsaid's adverse effects
Definition
may slow healing time.
Term
fluoromethalone adverse effects
Definition
High concentrations of this drug may raise IOP.
Term
neomycin adverse effects
Definition
may cause contact sensitivity and should not be used in patients with a history of this problem.
Term
fluoromethalone adverse effects
Definition
These drugs should not be used prophylactically before or after surgery. They may cause retinal neurotoxicity in cats if administered systemically. These drugs may cause crusting around the superficial part of corneal defects, conjunctival hyperemia, bad taste in the mouth, foreign body itching sensation, photophobia, edema of the eyelid(s), keratitis, and nausea. Some allergic reactions have been reported
Term
sulfacetamide adverse effects
Definition
GI disturbances, allergies, renal damage, and damage to lacrimal acinar cells. This drug is contraindicated in patients with hypersensitivity problems or in patients with blood dyscrasias.
Term
natamycin adverse effects
Definition
may cause worsening of corneal edema
Term
povidone iodine precautions
Definition
These solutions need to be lavaged from the eye after no more than 5 minutes to prevent corneal epithelial damage
Term
itraconazole precautions
Definition
Personnel treating horses with this drug should wear gloves to avoid having their skin absorb the DMSO.
Term
trifluiridine adverse effects
Definition
must be administered quite frequently to obtain acceptable results. If cats do not respond well within a 3-week period, they are not likely to respond to this drug at all. Therefore, use should be discontinued. The conjunctiva and eyelid margins may be irritated in cats during therapy with this drug.
Term
acyclovir and valacyclovir adverse effects
Definition
Cats are sensitive to; these drugs may cause fatal myeloid dysplasia in the species
Term
famciclovir precautions
Definition
should be used in cats with extreme caution
Term
cyclosporine precautions
Definition
Patients are usually given this drug for life to keep KCS symptoms under control. If the therapy is stopped, the clinical signs often return.
Term
Squinting of the eye
Definition
blepharospasm
Term
A waxy secretion of the glands of the external ear canal
Definition
cerum
Term
Inflammation of the conjunctiva
Definition
conjunctivitis
Term
Paralysis of the ciliary muscle
Definition
cycloplegia
Term
Eyelashes emerge through the meibomian gland opening at the eyelid margin in a misdirected way, causing the eyelashes to touch and irritate the corneal surface.
Definition
Distichia (distichiasis
Term
rolling outward (i.e., away from the eye) or sagging of the eyelid. Many times, the conjunctiva is plainly visible.
Definition
ectropion
Term
rolling inward (i.e., toward the cornea) of the eyelid.
Definition
entropion
Term
group of eye diseases characterized by increased intraocular pressure that results in damage to the retina and the optic nerve.
Definition
glaucoma
Term
Paralysis of the sympathetic nerve supply to the eye that may cause enophthalmos, ptosis of the upper eyelid, slight elevation of the lower eyelid, constriction of the pupil, and narrowing of the palpebral tissue.
Definition
Horner's syndrome
Term
condition in which red blood cells are present in the anterior chamber of the eye(s)
Definition
hyphema
Term
injection into the anterior chamber of the eye.
Definition
intracameral injection
Term
An agent that promotes normalization of the development of keratin.
Definition
keratitis
Term
Dilation of the pupil
Definition
mydriasis
Term
type of primary glaucoma of the eye in which the angle of the anterior chamber remains open, but filtration of the aqueous humor is gradually reduced, causing an increase in intraocular pressure.
Definition
open angle glaucoma
Term
Infestation of ear mites.
Definition
otoacariasis
Term
vascular layer of the eye that comprises the iris, ciliary body, and choroid.
Definition
uvea
Term
Inflammation of the uvea
Definition
uveitis
Term
opthalmic administration types
Definition
ointment
drops

can have local or systemic effects
Term
treat open angle glaucoma
Definition
carbonic anhydrase inhibitors
Term
uses for ocular anesthetics
Definition
relief of corneal portion during exam
foreign body removal
tonometry
corneal stains
Term
otic antiparasitics
Definition
pyrethrins
selamectin
ivermectin/milbemycin
Term
signs if ototoxicity
Definition
head tilt
walking in circles
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