Soft tissue masses (lumps and bumps):

Lower Lip

More likely

• Mucocele
• Fibroma

Likely

• Squamous cell carcinoma

Less likely

• Other mesenchymal tmors
• Salivary duct cyst
• Salivary gland tumor
• Keratoacanthoma

Soft tissue masses (lumps and bumps):

Upper lip

Likely

• Fibroma
• Salivary gland tumor
• Salivary duct cyst

Less likely

• Minor gland sialolith
• Other meseschymal tymors
• Nasolabial cyst

Soft tissue masses (lumps and bumps):

Buccal Mucosa

More likely

• Fibroma

Likely

• Lipoma
• Mucocele

Less Likely

• Hyperplastic lymph node
• Other mesenchymal tumors
• SCC
• Salivary gland tumor

Soft tissue masses (lumps and bumps):

Gingiva/Alveolar Mucosa

More likely

• Parulis
• Epulis fissuratum
• Pyogenic granuloma
• Peripheral ossifying fibroma

Likely

• Peripheral giant cell granuloma
• Fibroma

Less Likely

• SCC
• Metastatic tumors
• Gingival cyst of the adult
• Traumatic neuroma
• Kaposi's sarcoma
• Peripheral odontogenic tumors
• Congenital epulis

Soft tissue masses (lumps and bumps):

Floor of mouth

Likely

• Ranula/mucocele
• Sialolith
• SCC
• Lymphoepithelial cyst

Less Likely

• Epidermoid or dermoid cyst
• Salivary gland tumors
• Mesenchymal tumors

Soft tissue masses (lumps and bumps):

Tongue

More Likely

• Fibroma

Likely

• SCC
• Mucocele

Less Likely

• Granular cell tumor
• Other mesenchymal tumors (lymphangioma, hemangioma, neurfibroma, osseous choristoma)
• Pyogenic granuloma
• Salivary gland tumor
• Lingual thyroid

Soft tissue masses (lumps and bumps):

Hard or soft palate

More likely:

• Palatal abscess
• Leaf-like denture fibroma

Likely:

• Salivary gland tumor
• Kaposi's sarcoma
• Nasopalatine duct cyst

Less likely:

• Other mesenchymal tumors (fibroma, hemangioma,
• SCC
• Mucocele/salivary duct cyst
• Lymphoma
• Melanocytic nevus/melanoma
• Necrotizing sialometaplasia
• Adenomatoid hyperplasia of minor salivary glands

Soft tissue masses (lumps and bumps):

Multiple lesions

Likely:

• Kaposi's sarcoma
• Neurofibromatosis type I

Less likely:

• Multifocal epithelial hyperplasia
• Amyloidosis
• Granulomatous diseases (sarcoidosis, Crohn's disease, leprosy)
• Multiple endocrine neoplasia type 2B
• Tuberous sclerosis
• Multiple hamartoma syndrome

Soft tissue masses (lumps and bumps):

Midline neck lesions

Likely:

• Thyroid gland enlargement

Less Likely:

• Thyroglossal duct cyst
• Dermoid cyst
• Plunging ranula

Soft tissue masses (lumps and bumps):

Lateral neck lesions

More Likely:

• Reactive lymphadenopathy

Likely:

• Epidermoid cyst
• Lipoma
• Infectious mononucleosis
• Metastatic carcinoma
• Lymphoma

Less Likely:

• Salivary gland tumor
• Submandibular sialadentitis
• Cervical lymphoepithelial cyst
• Granulomatous diseases (TB, sarcoidosis)
• Cat-scratch disease
• Cystic hygroma
• Plunging ranula

More Likely

• Hyperplastic gingivitis

Likely

• Drug-related gingival hyperplasia (phenytoin, Ca channel blockers, cyclosporin)

Less Likely

• Gingival fibromatosis
• Leukemic infiltrate
• Wegener's granulomatosis
• Scurvy