Term
|
Definition
| Less effective than codeine and w negligible antitussive action |
|
|
Term
| Propoxyphene rx interactions |
|
Definition
fatalities reported w EtOH
Inc effects of warfarin
Inc toxicity of carbamazepine |
|
|
Term
| Propoxyphene Side effects (1+4) |
|
Definition
life-threatening resp dep
Overdose:
arrythmias
ciculatory colapse
convulsions
coma |
|
|
Term
|
Definition
Partial mu agonist, 25-50x more potent than morphine
Kappa antagonist
Long duration of action
Rx post-op pain, cancer, trauma, MI pain, trigeminal neuralgia
Used to reduce opiate addiction and reverse fentanyl-induced anesthesia |
|
|
Term
| Buprennorphine rx interactions |
|
Definition
| Resp or CV collapse w DIAZEPAM |
|
|
Term
| Buprenorphine side effects |
|
Definition
|
|
Term
|
Definition
kappa agonist
weak antagonist and mu and delta rec
relieves moderate pain thru kappa rec |
|
|
Term
|
Definition
Less euphoria than morphine
Resp dep in hi doses
Inc BP and myocardial workload
**Should not be given post-MI |
|
|
Term
|
Definition
Central acting analgesia
Inh norepi and serotonin re-uptake in CNS
Weak mu receptor agonist |
|
|
Term
|
Definition
| may inc adverse effects of MAO inh |
|
|
Term
|
Definition
urine retention
constipation
anxiety
anorexia
RASH |
|
|
Term
|
Definition
No substantial action at normal doses in normal individuals
Affinity for all three rec types
Used for life-threatening narcotic OD
Short half life |
|
|
Term
|
Definition
|
|
Term
|
Definition
Inc BP
Can cx analgesia reversal
Too rapid reversal can cx sweating, arrythmias/tachycardias, N/V |
|
|
Term
|
Definition
Similar to naloxone but w longer duration
Oral, 3/wk
Useful in detox |
|
|
Term
| Naltrexone rx interactions |
|
Definition
|
|
Term
|
Definition
| life-threatening hepatotoxicity |
|
|
Term
| Short term induction of tolerance to morphine |
|
Definition
| Mu and delta rec become phosphorylatedby PKA, PKC AND beta rec kinase |
|
|
Term
| Long term Induction of tolerance to morphine |
|
Definition
| Upregulation of CREB makes Na channels tonically overactive |
|
|
Term
| Early sx of opioid abstinence syndr |
|
Definition
Anxiety
Lacrimation
Yawning
Piloerction
Rhinorrhea
Dilated pupils
Anorexia
Tremor |
|
|
Term
| Late sx of opioid abstinence synd |
|
Definition
N/V
Diarrhea
Fever
Ab px
HTN
Tachy
Leukocytosis
Insomnia |
|
|
Term
|
Definition
Methadone
Long halflife cx longer but less intense withdrawal
lessens hi and lo of withdrawal
Doesn't require naltroxene |
|
|
