Term
| mu receptor analgesic effects |
|
Definition
MOST RXS ACT ON MU REC
supraspinal
spinal
peripheral |
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Term
| delta rec analgesic effects |
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Definition
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Term
| kappa rec analgesic effects |
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Definition
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Term
|
Definition
Resp depression
pupil constriction
reduced GI lotility
EUPHORIA
sedation
PHYSICAL DEPENDENCE |
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|
Term
| Other delta rec effecs (2) |
|
Definition
resp depression
reduced GI motility |
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|
Term
| Other kappa rec effects (5) |
|
Definition
pupil constriction
reduced GI motility
DYSPHORIA
sedation
physical dependence |
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Term
|
Definition
Dec Ca influx in primary sensory nr and synaptic vesicle release
Post-syn mu rec inc K conductance and dec post-syn response
Inh of adenylyl cyclase, dec cAMP, and inh of Na channels (Na channel phosphorylated) |
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Term
|
Definition
Analgesia
Cough suppression
Resp sedation
*High first pass effect |
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Term
| Morphine contraindications (3) |
|
Definition
asthma -due to bronchoconstriction
Neonates- can't fully metabolize and do not have fully developed BBB
Hypertensive crisis w MAO inh |
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|
Term
| Morphine side effects (4) |
|
Definition
Resp depression and CO2 retention cx inc cerebrospinal fluid pressure
Bradycardia/cardiac arrest
Convulsions in infants/children
Pinpoint pupils in overdose |
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Term
|
Definition
Actions similar to morphine, but w longer duration
Used to rx opioid abuse |
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|
Term
| Methadone rx interactions |
|
Definition
CNS depressants inc depression
cimetidine adds to sedation
amphetamines may potentiate CNS stimulation |
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Term
|
Definition
| life threatening resp depression |
|
|
Term
|
Definition
Similar to morphine, but less potent, and shorter duration of action
Does not suppress cough or cx pinpoint pupil |
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|
Term
| Meperidine contrindications |
|
Definition
| MAO inh cx severe resp depression, hyperpyrexia and convulsions |
|
|
Term
| Meperidine rx interactions (6) |
|
Definition
incompatible w:
aminophylline
pentobarbital
thiopental
heparin
methicillin
sodium bicarb |
|
|
Term
| Meperidine side effects (4) |
|
Definition
significant antimusarinic effect
negative inotropic action
resp dep
cardiac arrest |
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Term
|
Definition
| similar to morphine BUT much more potent and fast-acting |
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Term
|
Definition
incompatible w:
pentobarbital and thiopental
MAO inh may cx hypertensive crisis |
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Term
|
Definition
Used for decreasingly severe phasic pain
Less efficacious than morphine
Used in combo w aspirin or acetaminophen
Effective as antitussive and antidiarrheal
Less addictive than morphine |
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Term
|
Definition
| Coma possible w chlordiazeproxide |
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|
Term
|
Definition
life-thretening resp dep
circulatory collapse
convulsions |
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Term
|
Definition
| similar to codeine, but more addictive and w slightly more antitussive action |
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Term
|
Definition
| life-threatening resp dep |
|
|
Term
|
Definition
No antitussive action, but 10-12 times more potent than codeine
Often given in combo w aspirin or aceto |
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Term
|
Definition
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