Term
| Clinical appearance of Urticaria and Angioedema |
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Definition
Urticaria: Cutaneous Wheal and Flare, Itchy Fleeting, blanch with pressure
Angioedema: Localized deep swelling, not in a dependent area |
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Term
| Major causes of IgE and Non-IgE Urticaria |
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Definition
IgE: B-lactams, sulfa drug, Food, Insect, Latex
Non-IgE: Infections, Physical, Meds: Narcotics, Contrast dye
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Term
| What is the most common cause of non-IgE meadiated anaphylaxis |
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Definition
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Term
| Angioedema Signs and the most likely cause |
|
Definition
Deep Ct Swelling
Lips, Face, Genitals, Bowels
ACE-Inhib: Bradykinin Release(Prob Most common) |
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Term
| How do you treat Uticaria |
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Definition
Acute resolves
Avoid Trigger
H1, H2
Corticosteroids: For severe or Antihistamine resistant |
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Term
| What is the pathophysiology of Anaphylaxis |
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Definition
IgE: Sensitization, 2nd Exposure-> Degranulation, Systemic Histamine and Tryptase
Non-IgE: Direct Mast Activation |
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Term
| What are the clinical signs of Anaphylaxis in order of most common by organ system |
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Definition
Cutaneous: itching, flushing, Urticaria, angioedema
Respiratory: rhinorrhea, SOB, wheeze
GI: nausea, vomit, diarrhea, cramping
Cardiovascular: tachycardia, hypotension
Neurologic: anxiety, confusion
Ocular |
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Term
| How is the diagnosis of Anaphylactis made |
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Definition
| Almost always clinically, but Histamine and Trypase levels can be monitored |
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Term
| What are types of courses in anaphylaxis |
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Definition
Uniphasic: Symptoms resolve in an hour
Biphasic: Symptoms reappear after assymptomatic period
Protraction: Can last days w/o resolve |
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Term
| What characteristics are associated with a worse prognosis in anaphylaxis |
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Definition
Asthma
CV disease
B-Block
Late Epinephrine administration |
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Term
| How do you treat anaphylaxis |
|
Definition
Lie down feet up
Epinephrine
Intubate, IV
H1/H2, Steroids, Albuterol |
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