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Opat 2
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Biology
Graduate
01/12/2012

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Term
focal fibrous hyperplasia
Definition
gingival counterpart to traumatic fibroma ( cheek biting - most common tumor in oral cavity
Term
connective tissue
Definition
collagen fibers, fibroblast , undifferentiated mesenchymal , blood veseels , lymphoid
Term
fbrous lesions
Definition
lighter pink to red , painless , tx - surgical excision
Term
peripheral fibroma
Definition
may affect submucosa and pdl , young adults , anterior gingiva m raised nodule ( ped or sessile ) , no erosion
15% recur
Term
subtypes of peripheral fibroma
Definition
peripheral ossifying -osteoid
giant cell ( stellate )
periodontoma ( odontoma )
Term
Cowdens syndrome
Definition
multiple fibromas PTEN
buccal mucosa , lateral border of tongue / lower lip
Term
mass in tongue
Definition
neurofibroma
neurilemmoma
granular cell
Term
mass in lip
Definition
lipoma , mucocoela , salivary galnd , neoplasm
Term
generalized hyperplasia
Definition
local factors
leukemia
drugs dilantin, phenytoin , nifedinea and calcium channel blockers
Term
hereditary gingival fibromatosis
Definition
child with condition of fibrous
Term
hyperplastic scar
Definition
denture induced hyperplasia requires surgery
Term
solitary fibrous tumor
Definition
tumor of pleura, CD 34+ , haphazard spindle cell , circumscribed
DD: leiomyoma, hemangioperiocytoma, benign fibrous histiocytoma
Term
soft tissue myoma
Definition
gelatinous ( palate , infiltrate , rare - Carneys syndrome , recurrence , Diffuse blend
Term
nasopharyngeal angiofibroma
Definition
diagnostic- injection
age 20s , boys, blue swelling
clefting nasopharynx
tx - surgery , hormone
unencapsulated
recurrence common, rarely found orally
Term
giant cell angiofibroma
Definition
CD 34+ not common in oral , orbit
Term
nodular fascitis
Definition
mistaken for malignacy
sometimes symptomatic
trunk and extremeties
HC - slender, feather life multinucleated giant cells
DD- fibromatosis , fibrohistiocytoma, fibrosarcoma , myofibroma
( smooth muscle like cells )
DD
Term
myofibromatosis
Definition
multifocal - fatal
Term
myofibroma
Definition
H andN , circumscribed , biphasc growth patter , + smooth muscle (-) desmin, CD 34(-) , (-) S100
Term
fibromatosis
Definition
aggressive ,
superficial - not in oral cavity
deep seated ( oral cavity
60% extra abdominal , females 2:1
mandible , soft tissue - radioopaque
affects children , young adults
residual skeletal muscle
(-) for all of actin , desmin , s100
Term
fibrosarcoma
Definition
malignant
herringbone
H and N , secondary ulceration, young adult
bone lesion metastize
Term
benign fibrohistiocytic
Definition
rare , well demarcated
extremetics and trunk
"storiform, mat-like "
Term
malignant fibrohistiocytic
Definition
pleomorphism , adult men > women
DD - skeletal , smoot , adipose cancer
Term
lymphangioma
Definition
congenital , involution does not occur
20s , makes "crepitant" sound
tongue - macroglossia
nonencapsulated , surgical
Term
cystic hygroma
Definition
lymphangioma of neck
Term
Hemangiopetcytoma
Definition
benign tumor , oval to spindle
no predilection
soft tissue / intraosseous
"staghorn"vessels
tx . wide surgical excision ( undiff) , intermediate tumor ( unpredictable behavior ) , Ki67 - prolifer
Term
angiosarcoma
Definition
malignant tumor , rare - endothelial
50% skull /forehead
"hubnail"
tx - poor prognosis - face /scalp
better - oral
Term
traumatic neuroma
Definition
( amputation)
caused by injury /transection
inflam/ scarring / prolif
haphazard tortuous
also intraosseous
tx - surgical incision
dx - local anesthestic
50% painful
Term
granular cell
Definition
+ s 1000
females, mostly tongue
asymptomatic
over pseudoepitheliomatous hyperplasia
DD- traumatic fibroma
neurofibroma, schwannoma , PEN
Term
congenital gingival granular cell
Definition
(-) s100
epulis , anterior max, girls
Term
NF 1,2,3
Definition
mostly occur in the tongue
Term
Schwannoma
Definition
antitony A - palisaed
antitony B - esophilic c- haphazard
Term
neurofibroma
Definition
von Recklinghausen diseae , spindle shaped
+s100
autosomal dominant ,
Term
MENST
Definition
carcinoma of thyroid
pheochromocytoma of adrenal
mucaosal neuroma
marfanoid body
Term
PEN
Definition
( solitary lesion , tumor of three lies
Term
MPNST
Definition
from neurofibroma or complication of it , parasthesia ( malignancy ), 40s ( earlier than the NF1 )
IHC - + s100 + neurofilaments
DD- fibrosarcoma , leiomyosarcoma
Term
olfactory neuroblastoma
Definition
esthesioneuroblastoma
young adilts , nasopharynx / max sinus
"round blue cell tumor" pseudorosette, roseete
IHC- + neurofilaments , chromogranin, sypolysin
DD- lymphoma, rhadomyosarcoma, Ewing sarcoma , undiff carcinoma
malignant
Term
myositis ossificans
Definition
two type- focal (trauma ) ,systemic progressive
DD - osteosarcoma
tx surgical
Term
leiomyoma
Definition
smooth muscle
rare in oral cavity
DD - NF 1 ,2 3,
Term
leiomyosarcoma
Definition
mostly intraoral , smooth muscle
DD- other malignancies - MPNST , fibrosarcoma
*** > 2 mitotic events
Term
rhabdomyoma
Definition
skeletal h and n
adults easy to identify - looks like skeletal muscle
Term
rhabdomyosarcoma
Definition
strap-like
most common soft tissue sarcoma in peds
Term
lipoma
Definition
fat tissue , slow , of academic interest
Term
liposarcoma
Definition
DD - Benign process
slow , well diff
Term
skeletla
Definition
only has desmin
Term
vascular
Definition
CD34
Term
smooth muscle
Definition
actin / desmin
Term
melanocytic
Definition
symmetric , asymptomatic , well demarcated
afro, asian , med
dd - smoking associated ,Peutz Jegher , melanomas
Term
smokers melanosis
Definition
anterior labial gingiva
20% of smokers , women more affected
DD - same as others as well as physiological pigment
Term
oral melanomas macule
Definition
non malignant potential , lip unkown cause, well demarcated
multiple - can be associated with systemic Peutz Jeghers ,
Term
Peutz Jegher
Definition
control tummor supressor gene- polypsis --> cancer ovarian , pancreas, breast
autosomal dominant
intraoral
Term
addison
Definition
hypoadrenalcortisol
bronzing / ACTH
oral lesions are first manifestation of disease
Term
melanocytic lesions
Definition
biopsy
DD -rarely superf, melanoma , palatal blue nevi , amalgam tattoo,
multiple peutz jegher - addiso n
Term
nevomelanocytic nevus
Definition
mole, non malignant poitential in nevi , all should be excised , biopsy
junction
compound
intramucosal ( most common
blue nevus
Term
oral melanoma
Definition
intraoral melanoma is rare
two types : invasive - vertical growth
in situ - prolonged invasive
2% of all cancers
Term
amalgam tattoo
Definition
most common pigment of oral cavity
occurs after extraction or removal
Term
squamous papilloma / oral wart
Definition
most freq paipilly growth in the oral growth
HPV 2,6, 11 , low level of infectivity
AODS = dysplasia - HPV 16,18
DD - papillary hyperplasia , verruciform xanthoma
Term
papillary hyperplasia
Definition
removable prosthesi , hard palate , C albicans
DD - hard to miss
Term
van Woude Syndrome
Definition
syndromic cleft lip w or wo cleft palate
paramedian lip pits
IRF6 NSC - 18% its found
Term
cleft lip
Definition
M> f asians > white > black
1:700 -1:1000
80% unilateral, 20% bilateal
Term
cleft palate
Definition
F> M =across
1:1500-3000
isolate cleft 30%
Term
Xlinked cleft
Definition
ankyloglossia - frenum of tongue with gingiva
predom male
TBX 22
Term
Ectodermal dysplasia
Definition
thinning hair
ectrodactlyly
autosomal recessive
PVR 1 - oligodontia
Term
non syndromic clefting
Definition
multifactioral ,
TGFb3 - fusion
MSx 1 - tooth form
folate - fusions of palate , vit A , riboflavin
p63 - ectodermal dysplasia
infec- rubella
alcohol , smoking, retinouds m methotrexate ,dilanti n
Term
cherubism
Definition
autosomal dominant , SH3BP2
-5yrs onset , swelling mandible
teeth displaced eruption
multiocular radiolucency , look like a central giant cell
Term
cleidocranial dysostosis
Definition
midface hypoplasia , crowding **
Term
crouzon syndrom
Definition
craniofacial dysostosis , premature fuson FGFR 2 and 3
Term
Treacher collins syndrom
Definition
mandibulo facial dysostosis , hypoplasia branchial arches 1 and 3 TCOF 1
Term
osteopetrosis
Definition
defect in osteoclast ,infantile - most deadly , radioopacity ,
three types AR AR AD delayed tooth eruption
Term
pagets disease
Definition
osteitis deformans > 50 adults
European , resorption , vascular and sclerosising ( opacity )
cotton wool \hypercementosis
dentist- first to recognized
complication osteosarcoma , osteonecrosis
Term
germination
Definition
no change in tooth number - fusion
Term
fusion
Definition
usually central incisors , change in tooth number
Term
concrescence
Definition
max molars , difficulted with extraction
Term
dilaceration
Definition
traumatic episode , curving of tooth
Term
taurodontism
Definition
( pulp space )
cause not alwaysknown
found in Downs syndrome , ectodermal dysplasia, amelo I ., orofacial digitalis and other
Term
dens in dente
Definition
invagination of tooth , deep pocket cares and pulp exp . max lateral incisors
Term
anodontia
Definition
rare, ectodermal dysplasia
partial anodontia - hypodontia
- crouzons , ehlers danlos ,
-3rd molars most common, second bicuspids, lateral incisor
Term
Ectodermal dysplasia
Definition
x - linked recessive , hypohidrosis, hypotrichosis , hypodontia ,frontal bossing , low nasal bridge , protrusive live , oblique insert ears
Term
supernumerary
Definition
distomolar
mesiodens - 4th molars , central incisors
odontomas
Term
Gardner syndrome
Definition
polyposis APC genes , adenocarcinoma include odontoas , supernumerary , impacted teeth
Term
cleidocranial dysplasia
Definition
gnes regulates osteoblast gene exp . short status , frontal bossing
Term
Delayed eruption
Definition
rickets
cretinism
cleidocranial dysplasia
hypothyroidism
local factors
Term
impacted teeth
Definition
3rd molars
max cuspids -
biscuspids
supernumerary
Term
ankylosed primary teeth
Definition
periodontal soft tissue
dental carie
pericoronitis
trauma
Term
attrition
Definition
bruxism , clenching
Term
abrasion
Definition
tooth brushking
Term
abfraction
Definition
loss of cervical tooth
Term
erosion
Definition
chemical
Term
periomolysis
Definition
loss of enamel , bulimia
Term
odontodysplasia
Definition
alteration , org tooth enamel , dentin, cementum
Term
amelogenesis imperfecta
Definition
hypoplastic I lack of thickness
hypmaturation II
hypocalcified III affected primary / permanent
mix of all IV
autosomal dominant / x linked
Term
enamel hypoplasia
Definition
nutrtion metabo dist , vit def
infection diseae , inflam , lpocal infection , trauma , fluoride , pharm
Term
Turners Tooth
Definition
permanent tooth damage during development
DD - enamel hypoplasia , fluorisis ,AI
Term
Osteogenesis imperfecta
Definition
blue sclera COLI A2
Term
Dentigenesis Imperf.
Definition
I - assoc .oof osteo I ( translucent
II - indep of osteo I
( obliteration of pulp chambers )
III brandywine
Term
Dentin dysplasia
Definition
amber translucency
rootless - shrt roots
no pulp
autosomal dominant
III - pulp stones
Term
color - exogenous
Definition
caries, age , restor, tobacco, coffeee
chromogenic bacteria, metals
Term
endogenous
Definition
tetracycline ,fluoride, porphyrins( red urine) , bilirubmins , hemosiderrrn
Term
Resorption
Definition
ext - trauma - impacted tooth
iint - pink tooth - causee unknown
dentinoclast, Howship lacunae
Term
caries
Definition
most common form of injury that causes pulpitis
Term
heat friction chemical and filling material
Definition
potential irritants for pulpitis
Term
focal reversible pulpitis
Definition
acute, mild inflammatory pulpa lreaction thatfollows carious destruction of a tooth or placement of a large metallic filling without an insulating base
hypersensitive to thermal and electric stimuli
- can be reversible if cause is remoed
Term
dilation and engorgement of blood vessesl
Definition
predominant feature of focal reversible pulpitis
Term
acute pulpitis
Definition
severe , progression of focal reversible pulpitis pain
intensified pain to heat or cold response
Term
chronic pulpitis
Definition
long term low grade , dull ache
px. - mild reduced response
Term
chronic hyperplastic pulpitis
Definition
molar teeth of children / young adults
Term
irreversible
Definition
acute pulp and chronic hyperplastic- irreversible
chronic -death
Term
acute periapical abscess
Definition
severe pain pain in area of nonvital tooth , hypersensitive to percussion
involved tooth unresponsive to electric/ heat ( pulp necrosis
Term
periapical granuloma
Definition
chronic nonvital tooth - lucency
Term
periapical cyst
Definition
lucency,
Term
cellulitis
Definition
bilateral - ludwigs angina
cavernous sinus thrombosis- fatal
drainage not established - purulent exudate
Term
acute osteomyelitis
Definition
infection , results from ext of periapical abscess - 1st
physical injury-2nd
bacteremia - 3rd
pain
diffuse radiolucent when 60% bone resorbed
parathesia of lower lip ,tx-
antibiotic / drainage
Term
chronic osteomyelitis
Definition
radio image is mottled , motheaten
low grade
Term
osteoradionecrosis
Definition
20% patients that have underone tumor , irradation
Term
chronic osteomyelitis
Definition
most infections (bacteria)
cx- variable pain swelling drainage
rx- lucent or mottled patern
hyperbaric oxygen
tx- antibiotic ,sequestectomy
Term
chronic osteomyeli with prolif periositis
Definition
garre osteomyelitis, sequela of tooth abscess , asymptomatic bony , hard swelling , childen
rx- lucent or mottledpattern with concentric periosteal opacities
tx- tooth removal , antibiotis
Term
diffuse sclerosing osteom
Definition
low grade infection, pulpits , perio disease
cx. occasional pain ,swelling, drainage
mandible
rx. opacification through jaw - mandible or maxilla
primarily affect middle age black women
tx. antibiotics
Term
focal sclerosing osteitis
Definition
low grade focal bone irritation
asymptomatic found on routine examination
opaque emass usally root apex
treat offending tooth
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