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Definition
| Closely resemble normal metabolites and fool cancer cells into using them. They can't function as proper metabolites therefore, impair cell division. |
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Term
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Definition
| Damage the Cell's DNA and interrupt DNA or RNA synthesis. Exactly how the interruptions occur varies with each agent. |
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Definition
| Interfere with the formationof microtubules so cells cannot complete mitosis during cell division. As a result the cancer can only divide once. |
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Definition
| Cross-link DNA, making the two DNA strands bind tightly together. This prevents proper DNA & RNA synthesis, inhibiting cell division. |
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Definition
| Disrupt an enzyme needed for DNA synthesis and cell division. These drugs prevent proper DNA maintence, causing DNA breakage and cell death. |
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Term
Mustargen
(mechlorethamine) |
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Definition
Func class-Alkylating agent
Action- Responsible for cross-linking DNA strands leading to cell death.
Uses- Hodgkin's disease, leukemias, lymphomas, lymphosarcoma, ovarian, breast lung carcinoma; neoplastic effusion.
Side effects- N&V,HA, leukopenia, alopecia.
Metabolized in liver excreted in urine.
Assess- CBC, renal function,hepatic studies,buccal cavity for dryness and sores. |
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Term
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Definition
Func. class-Alkylating agent
Action- Alkylates DNA responsible for cross-linking DNA strands; activity is not cell cycle phase specific.
Uses- Hodgkin's disease; lymphomas; leukemia;cancer of female reproductive tract; breast; lung; prostate; multiple myeloma; neuroblastoma; retinoblastoma; ewing's sarcoma; disseminated neuroblastoma.
Side efffects- HA, N&V, Hemorragic cystitis, hepatotoxicity
Assess- renal studies, hemorrhagic cystitis, I&O, CBC, Monitor temp., Hepatic studies |
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Term
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Definition
Func. class- Alkylating agent
Action- Alkylates DNAUses- Brain tumors such as glioblastoma, medulloblastoma, brain stem glioma, astrocytoma, ependymoma, metastatic brain tumors; multiple myeloma, non-hodgkin's, hodgkin's disease, other lymphomas
Side effects- N&V, hepatotoxicty, renal failure.
Assess- CBC, hepatic studies, Renal studies, chest x-ray |
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