Term
| Which drugs are monoclonal antibodies? |
|
Definition
Trastuzumab (Herceptin)
Cetuximab (Erbitux) |
|
|
Term
How does Trastuzumab (Herceptin) work?
What does it primarily treat? |
|
Definition
HER 2 receptor
Metastatic Breast Cancer |
|
|
Term
How does Cetuximab (Erbitux) work?
What 2 caners does it treat? |
|
Definition
HER 1 receptor
Advanced Squamous Cell Carcinoma (head and neck)
Colorectal Cancer |
|
|
Term
| Which drugs are the tyrosine kinase inhibitors? |
|
Definition
| Drugs ending in "nib" + Temsirolimus |
|
|
Term
| What does Imatinib (Gleevec) treat? |
|
Definition
Chronic Mylogenous Leukemia (CML)
GIST (Gastrointestinal Stromal Tumor) |
|
|
Term
| What is Dasatinib used for? |
|
Definition
| In case of Gleevec Resistance |
|
|
Term
| How do Gefitinib and Erlotinib work? |
|
Definition
Inhibit EGF receptor
Used for NSCLC, but not 1st choice |
|
|
Term
|
Definition
PDGF, VEGF, Kit, Raf
(alternative to Sunitinib) |
|
|
Term
|
Definition
PDGF, VEGF, SCF
GIST + REC > Highly Vascularized |
|
|
Term
|
Definition
HER 2/ ErbB-2
Breast Cancer |
|
|
Term
| How does Temsirolimus work? |
|
Definition
Esterified rapamycin
Advanced renal cell carcinoma |
|
|
Term
| What are the Angiogenesis Inhibitors? |
|
Definition
| Avastin (bvacizumab)- used for colorectal cancer |
|
|
Term
| What are the DNA demethylating agents? |
|
Definition
| Decitabine- many leukemias + carcinomas |
|
|
Term
| What are the Proteasome Inhibitors? |
|
Definition
Bortezomib (Velcade)
Vorinostat |
|
|
Term
| What is Bortezomib used for? |
|
Definition
| Multiple myelomas (bone marrow) |
|
|
Term
| What is Vorinostat used for? |
|
Definition
| Cutaneous T Cell Lymphoma |
|
|
Term
| What drugs use Passive Immunization? |
|
Definition
Rituximab (Rituxan)
Irbritumomab (Zevalin)
Gemtuzumab |
|
|
Term
How does Rituximab work?
What is it used for? |
|
Definition
against CD20 antigen
treats NHL
Treats RA along with Methotrexate |
|
|
Term
| What is Ibritumomab used for and how does it work? |
|
Definition
|
|
Term
| How does Gemtuzumab work and what is it used for? |
|
Definition
against CD33 antigen
AML ( acute mylogenous leukemia) |
|
|
Term
| What all drug classes are antineoplastic agents- alkylating agents? |
|
Definition
Nitrogen Mustards
Thiotepa
Busulfan
Organoplatinum Compounds
Nitrosoureas
Procarbazine, Dacarbazine, & Temozolomide
Altretamine |
|
|
Term
| What drugs are Nitrogen Mustards? |
|
Definition
Mechloretharine
Chlorambucil
Melphalan
Bendamustine (Treanda)
Cyclophosphamide
Ifosfamide |
|
|
Term
| How does Mechoretharine work? |
|
Definition
dialkylator
Very potent
Used for HL (given IV) |
|
|
Term
| What is the antidote for Mechloretharine? |
|
Definition
| Thiosulfate- reacts with electrophillic sites on mustard causing increase in H20 solubility of compound causing elimination |
|
|
Term
|
Definition
Oral
HL
Chronic Lymphocytic Leukemia |
|
|
Term
|
Definition
Oral
Multiple Myeloma
Breast- Ovarian Cancer
Bone Marrow Transplant |
|
|
Term
|
Definition
|
|
Term
|
Definition
Oral and IV
widely used (breast cancer) |
|
|
Term
|
Definition
IV
widely used
causes neuro/kidney/ bladder toxicity |
|
|
Term
| What is Thiotepa used for? |
|
Definition
bladder, ovarian, and breast cancers
monoalkylates |
|
|
Term
| What is Busulfan used for? |
|
Definition
Refractory leukemias
bone marrow transplants |
|
|
Term
| What are the organoplatinum compounds? |
|
Definition
|
|
Term
| What is the dose limiting toxicity of organoplatinum compounds? |
|
Definition
|
|
Term
| What are the nitrosoureas? |
|
Definition
Carmustine
Lomustine
Streptozocin |
|
|
Term
|
Definition
IV
HL and NHL
Cross linking |
|
|
Term
|
Definition
|
|
Term
|
Definition
methylates DNA
IV
more water soluble; wont cross BBB
pancreatic/colon
HL
REnal Toxicity- dose limiting |
|
|
Term
| Do Procarbazine, Dacarbazine, and Temozolomide have Cross linking? |
|
Definition
|
|
Term
|
Definition
Made for an MAOi
Oral
Brain Cancer
HL--> MOPP
broken down by cyp and mao
Myelosuppression |
|
|
Term
|
Definition
alkylating agent
IV
HL; neuroblastoma
pair in injection site |
|
|
Term
|
Definition
|
|
