Term
abl
Associated tumor:
Gene product: |
|
Definition
Oncogene
CML
Tyyrosine kinase (abl, erb-B2, ret) |
|
|
Term
c-myc
Associated tumor:
Gene product: |
|
Definition
Oncogene
Burkitt's lymphoma
Transcription factor (like all the '-myc') |
|
|
Term
bcl-2
Associated tumor:
Gene product: |
|
Definition
Oncogene
Follicular and undifferentiated lymphomas (inhibits apoptosis)
Anti-apoptotic molecule |
|
|
Term
erb-B2
Associated tumor:
Gene product: |
|
Definition
Oncogene
Breast, ovarian, and gastric carcinomas
Tyrosine kinase (abl, erb-B2, ret) |
|
|
Term
ras
Associated tumor:
Gene product: |
|
Definition
Oncogene
Colon carcinoma
GTPase |
|
|
Term
L-myc
Associated tumor:
Gene product: |
|
Definition
Oncogene
Lung tumor
Transcription factor (like all the '-myc') |
|
|
Term
N-myc
Associated tumor:
Gene product: |
|
Definition
Oncogene
Neuroblastoma
Transcription factor (like all the '-myc') |
|
|
Term
ret
Associated tumor:
Gene product: |
|
Definition
Oncogene
Multiple endocrine neoplasia (MEN) types IIA and IIB
Tyrosine kinase (abl, erb-B2, ret) |
|
|
Term
c-kit
Associated tumor:
Gene product: |
|
Definition
Oncogene
Gastrointestinal stromal tumor (GIST)
Cytokine receptor |
|
|
Term
Rb
Associated tumor:
Gene product: |
|
Definition
Tumor suppressor gene
Retinoblastoma, osteosarcoma
Rb gene product blocks G1 -> S phase of the cell cycle |
|
|
Term
p53
Associated tumor:
Gene product: |
|
Definition
Tumor suppressor gene
Most human cancers, Li-Fraumeni syndrome
p53 gene product blocks G1 -> S phase of the cell cycle |
|
|
Term
BRCA1
Associated tumor:
Gene product: |
|
Definition
Tumor suppressor gene
Breast and ovarian cancer
DNA repair protein |
|
|
Term
BRCA2
Associated tumor:
Gene product: |
|
Definition
Tumor suppressor gene
Breast cancer
DNA repair protein |
|
|
Term
|
Definition
Tumor suppressor gene
Melanoma |
|
|
Term
|
Definition
Tumor suppressor gene
Colorectal cancer (associated with FAP) |
|
|
Term
|
Definition
Tumor suppressor gene
Wilms' tumor |
|
|
Term
|
Definition
Tumor suppressor gene
Neurofibromatosis type 1 |
|
|
Term
|
Definition
Tumor suppressor gene
Neurofibromatosis type 2 |
|
|
Term
|
Definition
Tumor suppressor gene
Pancreatic cancer
DPC = Deleted in Pancreatic Cancer |
|
|
Term
|
Definition
Tumor suppressor gene
Colon cancer
DCC = Deleted in Colon Cancer |
|
|
Term
PSA
Screen for:
Also elevated in: |
|
Definition
Screen for prostate carcinoma
Elevated in BPH and prostatitis |
|
|
Term
| Prostatic acid phosphatase |
|
Definition
|
|
Term
| CEA (Carcinoembryonic antigen) |
|
Definition
Very nonspecific, produced by ~70% of colorectal and pancreatic cancers
Also produced by gastric, breast, and thyroid medullary carcinomas |
|
|
Term
|
Definition
Nomrally made by fetus
Hepatocellular carcinomas
Nonseminomatous germ cell tumors of the testis (yolk sac tumor) |
|
|
Term
|
Definition
Beta-HCG = HCG
Hydatidiform moles
Choriocarcinomas
Gestational trophoblastic tumors |
|
|
Term
|
Definition
| Ovarian, malignant epithelial tumors |
|
|
Term
|
Definition
| Melanoma, neural tumors, astrocytomas |
|
|
Term
|
Definition
Metastases to bone
Obstructive biliary disease
Paget's disease of bone |
|
|
Term
|
Definition
Neuroblastoma
Lung and gastric cancer |
|
|
Term
TRAP
(Tartrate-resistant acid phosphatase) |
|
Definition
TRAP the hairy animal
Hairy cell leukemia: a B-cell neoplasm |
|
|
Term
|
Definition
| Pancreatic adenocarcinoma |
|
|
Term
|
Definition
| Thyroid medullary carcinoma |
|
|
