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Oncogenes and Tumor Suppressor Genes
First Aid 2012 p253
24
Medical
Graduate
01/16/2013

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Cards

Term
abl
Definition
oncogene
CML (9!;22)
tyrosine kinase
Term
c-myc
Definition
oncogene
Burkitt's lymphoma (8!;14)
transcription factor
Term
bcl-2
Definition
oncogene follicular (14;18!), undifferentiated lymphomas!!
anti-apoptotic
Term
erb-B2
Definition
oncogene
breast, ovarian, endometrial, gastric!! carcinomas
tyrosine kinase (EGF)
Term
ras
Definition
oncogene
colon carcinoma
GTPase
Term
L-myc
Definition
oncogene
lung tumor
transcription factor
Term
N-myc
Definition
oncogene
neuroblastoma
transcription factor
Term
ret
Definition
oncogene
MEN IIA, MEN IIB
tyrosine kinase
Term
c-kit
Definition
oncogene
GIST
cytokine receptor
Term
PML
Definition
oncogene
FAB M3 AML (15;17)
Term
Rb
Definition
tumor suppresor gene
retinoblastoma, osteosarcoma!!
Term
p53
Definition
tumor suppresor gene
Li-Fraumeni syndrome
Term
BRCA1
Definition
tumor suppresor gene
breast and ovarian cancer
Term
BRCA2
Definition
tumor suppresor gene
breast cancer
Term
p16
Definition
tumor suppresor gene
melanoma
Term
APC
Definition
tumor suppresor gene
colorectal cancer (FAP)
Term
WT1, WT2
Definition
tumor suppresor gene
Wilms' tumor
Term
NF1
Definition
tumor suppresor gene
neurofibromatosis type 1
encodes GAP protein that inactivates ras
Term
NF2
Definition
tumor suppresor gene
neurofibromatosis type 2
Term
DPC
Definition
tumor suppresor gene
pancreatic cancer
Term
DCC
Definition
tumor suppresor gene
colon cancer
Term
VHL
Definition
(tumor suppresor gene)
von Hippel-Lindau -- RCC + hemangioblastomas (retina, cerebellum, medulla)
Term
cyclin D1
Definition
oncogene
mantle cell (11;14)
Term
BRAF
Definition
oncogene
melanoma
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