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Onc:
Cancer genes and quick facts
84
Medical
Graduate
05/25/2012

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Cards

Term
Females: Incidence
Definition
1. Breast
2. Lung
3. Colon
4. Uterus
Term
Females: Mortality
Definition
1. Lung
2. Breast
3. Colon
4. Pancreatic
Term
Males: Incidence:
Definition
1. Prostate
2. Lung
3. Colon
Term
Males: Morality
Definition
1. Lung
2. Prostate
3. Colon
4. Pancreatic
Term
Aflatoxins (Aspergillus)
Definition
Hepatocellular carcinoma
Term
Vinyl chloride
Definition
Angiosarcoma(part of VAT)
Term
CCL4
Definition
Centrilobular necrosis; fatty change
Term
Nitrosamines (smoked foods)
Definition
Gastric cancer
SqCC of Esophagus
Term
Cigarette smoke
Definition
SqCC of larynx
SqCC/SCC of lung
RCC of kidney
Transitional cell ca. of bladder
Term
Asbestos
Definition
Mesothelioma
bronchogenic carcinoma
Term
Arsenic
Definition
SqCC of skin
Angiosarcoma (part of VAT)
Term
Angiosarcoma - VAT
Definition
1. Vinyl chloride
2. Arsenic
3. Thorotrast
Term
Naphthalene (analine/azo)dyes
Definition
Transitional cell carcinoma of bladder
Term
Alkylating agents
Definition
Leukemia
Term
HTLV-1
Definition
Adult T cell leukemia/lymphoma
Term
HBV, HCV
Definition
HCC
Term
EBV
Definition
Burkitt's lymphoma
Hodgkin's lymphoma
nasopharyngeal carcinoma
Term
HPV
Definition
Cervical
Vulvar
Penile/anal squamous cell carcinomas
Term
HHV-8
Definition
Kaposi's sarcoma
Body cavity fluid B cell lymphoma
Term
HIV
Definition
Primary CNS lymphoma
Term
H. pylori
Definition
Gastric adenocarcinoma and lymphoma
Term
Schistosoma haematobium
Definition
SqCC of transitional epithelium (bladder)
Term
Strep bovis
Definition
Eso, Stomach and colon cancer
Term
Chlonorchis sinensis
Definition
cholangiocarcionma
Term
abl
Definition
CML (tyrosine kinase)
Term
c-myc
Definition
Burkitt's lymphoma (transcription factor)
Term
blc-2
Definition
Follicular and undiff lymphomas (inhibits apoptosis)
Term
erb B2
Definition
Breast, ovarian, and gastric ca (tyrosine kinase)
Term
K ras
Definition
colon, lung, pancreatic tumors
Term
H ras
Definition
bladder/kidney cancers
Term
N-ras
Definition
melanomas, hematological malignancies
Term
L-myc
Definition
Lung tumor (transcription factor)
Term
N-myc
Definition
Neuroblastoma (adrenal) (transcription factor)
Term
ret
Definition
MEN IIA and IIB (pheos, medullar thyroid ca.) (tyrosine kinase
Term
c-kit
Definition
Gastrointestinal stromal tumor (GIST) (cytokine receptor)
Term
Rb
Definition
retinoblastoma, osteosarcoma
Term
p53
Definition
Most human cancers;
Li Fraumeni syndrome
Term
BRCA 1, 2
Definition
Breast and ovarian cancers; (DNA repair protein)
Term
p16
Definition
Melanoma
Term
APC
Definition
Colorectal cancer (associated with FAP)
Term
WT1
Definition
Wilm's tumor
Term
NF-1
Definition
Neurofibromatosis-1
Term
NF-2
Definition
Neurofibromatosis-2
Term
DPC
Definition
Pancreatic cancer
Term
DCC
Definition
Colon cancer
Term
Down syndrome
Definition
ALL, AML
Term
Xeroderma pigmentosum
Definition
Melanoma, basal cell carcinoma, and esp SqCC of the skin
Term
Chronic atrophic gastritis
Pernicious Anemia
Post-surgical gastric remnants
Definition
Gastric adenocarcinoma
Term
Tuberous sclerosis
Definition
Astrocytoma, angiomyolipoma, cardiac rhabdomyoma
Term
Actinic (solar) keratosis
Definition
SqCC of the skin
Term
Barrett's esophagus (GERD)
Definition
Esophageal adenocarcinoma
Term
Plummer vinson syndrome
Definition
SqCC of the Esophagus
PV is: atrophic glossitis, esophageal webs, anemia; all due to iron def)
Term
Cirrhosis (alcoholic, Hep B and C)
Definition
Hepatocellular carcinoma
Term
UC > Crohns
Definition
Colonic adenocarcinoma
Term
Paget's disease of bone
Definition
Secondary osteosarcoma
Fibrosarcoma
Term
Immunodeficiency states
Definition
Malignant lymphomas
Term
AIDS
Definition
Primary CNS lymphoma
Term
Autoimmune diseases
(Hashimoto's thyroiditis, myasthenia gravis)
Definition
Lymphoma
Term
Acanthosis nigricans (hyperpigmentation and epidermal thickening)
Definition
Visceral malignancy (stomach, lung, breast, uterus)
Term
Dysplastic nevus
Definition
Malignant melanoma
Term
Radiation exposure
Definition
Papillary thyroid carcinoma, leukemia
Term
Achalsia
Definition
SqCC of the eso
Term
Sjogren's syndrome
Definition
B cell lymphoma
Term
Tumor Marker:
PSA
Definition
Prostate specific Ag;
Prostate carcinoma; BPH; prostatits
Term
Tumor Marker:
Prostatic acid phosphatase
Definition
Prostate carcinoma
Term
Tumor Marker:
CEA
Definition
Carcinoembryonic Ag
Colorectal & pancreatic cancers
(also produced by gastric, breast and thyroid medullary ca)
Term
Tumor Marker:
alpha fetoprotein
Definition
HCC
Term
Tumor Marker:
Beta hCG
Definition
Hydatidiform moles
Choriocarcinoma
Gestational trophoblastic tumors
Term
Tumor Marker:
CA-125
Definition
Ovarian; malignant epithelial tumors
Term
Tumor Marker:
Alkaline phosphtase
Definition
Mets to bone
Obstructive biliary disease
Paget's disease of bone
Term
Tumor Marker:
Bombesin
Definition
Neuroblastoma
Lung and Gastric cancer
Term
Tumor Marker:
TRAP
Definition
(Tartrate resistant acid phosphatase)
Hairy cell leukemia
Term
Tumor Marker:
CA-19-9
Definition
Pancreatic adenocarcinoma
Term
Tumor Marker:
Calcitonin
Definition
Thyroid medullary carcinoma
Term
METS to Bone
Definition
PT Barnum Likes Kids
Prostate; Thyroid; Testicular; Breast, Lung, Kidneys
Term
METS to Brain
Definition
Lots of Bad Stuff Kills Glia
Lung, Breast, Skin (melanoma), Kidney (RCC), GI cancer
Term
METS to Liver
Definition
Cancers Sometimes Penetrate Benign Liver
Colon, Stomach, Pancreas, Breast, Lungs
Term
Tumor Marker:
S-100 Ag
Definition
Melanoma
Neural tumors, schwannoma
Astrocytoma
Term
Progression to CRC (sporadic) =85%
Definition
APC --> K-ras --> p53
Term
Progression to CRC (in U.C.)
Definition
p53 Early
APC Late
Term
CRC (non sporadic) =15%
Definition
HNPCC (Lynch I, II)
DNA mismatch repair defect
Microsatellite instability pathyway
Term
sis
Definition
astrocytoma, osteosarcoma
Term
TGF alpha
Definition
astrocytoma, HCC
Term
GFAP +
Definition
Astrocytomas
- GBM in adults
- Pilocytic astrocytoma in kids
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