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zapalenie limfoplazmocytarne |
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Łagodna Hiperplazja Mastocytarna Dobrze zróżnicowane mastocyty Devon Rex Sphinx Potwierdzać histopatem |
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Ziarniniak eozynofilowy basophilic amorphous material surrounded by many giant cells. Note the presence of some eosinophils (arrow) |
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Panniculitis, makrofagi piankowate |
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Plazmocytarne zapalenie opuszek |
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Dobrze zróżnicowana MCT u psa często włókna kolagenowe |
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MCT u psa włókna kolagenowe |
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Słabo zróżnicowana MCT u psa anizokarioza komórki wilojądrowe i atypowa mitoza |
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Kocia mastocytoma, komórki wieloboczne |
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Kocia mastocytoma wielojądrowa |
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Kocia mastocytoma atypowa many single cells oval to spindle in shape, with slightly indented nuclei and a granular cytoplasm. Note the high number of eosinophilic granules in the background |
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Plazmocytoma dobrze zróżnicowana |
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Plazmocytoma dobrze zróżnicowana |
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Plazmocytoma słabo zróżnicowana Anizokarioza,anizocytoza, komórki wielojądrowe tylko kilka komórek o morfologii plazmocytów |
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Plazmocytoma źle zróżnicowana komórki pleomorficzne |
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Plazmocytoma źle zróźnicowana całkowity brak cech plazmocytów |
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Plazmocytoma amorficzny kwasochłonny materiał to amyloid |
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Amyloid zabarwiony czerwienią kongo Plazmocytoma |
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Mięsak weneryczny, wysoka aktywność mitotyczna! charakterystyczna |
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Histiocytoma u psa 1. Wiele okrągłych komórek 2.jądro zwykle okrągłe położone centralnie 3.bogata bladoniebieska cytoplazma |
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Histiocytoma, uwaga żeby nie pomylić z plazmocytomą |
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Histiocytoma, zwróć uwagę na charakterystyczny nerkowaty kształt jąder |
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Histiocytoma, wakuole cytopalazmatyczne, uważaj na TVT |
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Histiocytoma w fazie regersji, limfocyty!! |
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Histiocytoza reaktywna, histiocyty z owalnym delikatnie ząbkowanym jąderem + limfocyty |
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Histiocytoza reaktywna, histiocyty z owalnym lub nerkowatym jądrem, słabo widoczne granice międzykomórkowe |
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Mięsak histiocytarny, ostra anizokarioza i zwakuolizowana cytoplazma |
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Mięsak histiocytarny, znaczna atypia i komórki wielojądrowe |
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Mięsak histiocytarny, ale komórki wrzecionowate atypowe i wielojądrowe. Samą cytologia cieżko było by odróżnić od niezróżnicowanego mięsaka tkanek miękkich |
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Mięsak histiocytarny, atypia i mitoza w komórce wielojądrowej.Samą cytologia cieżko było by odróżnić od niezróżnicowanego mięsaka tkanek miękkich |
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Postępująca histiocytoza u kota |
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Postępująca histiocytoza u kota, zauważ komórki z ząbkowanym jądrem |
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Postępująca histiocytoza u kota, ostre cechy złośliwości cytologicznej, preparat bogatokomórkowy duże histiocyty trochę limfocytów |
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Chłoniak epiteliotropowy komórki jednolitej wielkości z tylko niewielką atypią |
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Chłoniak epiteliotropowy komórki nowotworowe bez atypii neutrofile |
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Chłoniak nieepiteliotropowy Duża atpia |
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Chłoniak nieepiteliotropowy Cerebriform nuclei -> T |
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Zespół Sezarego Cerebriform nuclei -> T |
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Limfocyty nie nowotworowe |
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SCC komórki nie zróżnicowane pośród nich zrogowaciałe |
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Trichoblastoma - okrągłe skupiska komórek podstawnych |
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Feline apocrine cystomatosis many vacuolated macrophages fi lled with dark blue and coarse material |
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Feline apocrine cystomatosis many vacuolated macrophages fi lled with dark blue and coarse material Błękit Pruski barwi Żelazo |
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Liposarcoma komórki nowotworowe okołonaczyniowo |
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Liposarcoma Wielka komórka to lipoblast |
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Anaplastyczny mięsak tkanek miękkich z dużą liczbą komórek olbrzymich (kiedyś Złośliwa histiocytoma włóknista) |
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Czerniak, pseudoagregat komórek przypominających nabłonkowe |
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Ballon cell melanoma amelanot |
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Czerniak sygnetowatokomórkowy jądro mimoośrodkowo wewnątrzcytoplazmatyczne kwasochłonne ciałka |
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Niezróżnicowany czerniak amelanotyczny widoczne kryteria złośliwości |
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Pheochromocytoma Jednorodna populacja nagich jąder komórkowych, często w strukturach groniastych lub w rzędach |
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Pheochromocytoma Komórki w zlepach, obraz plazmocytoidalny |
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Plazmocytoma Aspirate from a round raised lesion on the skin around the stifle of a dog: The aspirate consists of many medium sized discrete round cells with round to slightly oval nuclei, smooth or clumped chromatin, no nucleoli, and moderate amounts of cytoplasm with distinct boundaries. There is a perinuclear clearing in most cells, suggestive of the Golgi apparatus, and a characteristic feature of plasma cells |
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Plazmocytoma Aspirate of a raised dermal mass on the pinna of a dog: The aspirate consisted of discrete round cells with eccentric round nuclei with smooth to clumped chromatin and dark blue cytoplasm with a hint of a perinuclear clearing. Several bi- or multinucleated cells (arrows) with similarly sized nuclei are seen. The cells have somewhat darker or brighter edges, mimicking so-called "flame cells". The cytologic features were consistent with an extramedullary plasmacytoma. Some of the cells contained a degree of cytoplasmic granularity, resembling mast cells (arrowheads) |
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Plazmocytoma Aspirate from a lip mass in a dog: The aspirate consists of numerous medium round or "discrete" cells with very round eccentric nuclei, somewhat coarse to clumped chromatin and a small to moderate amount of medium blue cytoplasm, with a hint of perinuclear clearing. Cell boundaries are relatively distinct. 1.Histiocytoma ma bardziej zróżnicowane kszałty jąder często wcięcia z jaśniejszą chromatyną 2.Jaśniejszą cytoplazmę 3.Komórki dwujądrowe rzadko w Histiocytomach, nie ma wielojądrowch 4.Typowa lokalizacja dla Plazmocytomy |
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Plazmocytoma The cells have quite clumped nuclear chromatin, mimicking nucleoli. Notice the distinct perinuclear clear zones in some cells |
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Plazmocytoma, Amyloid Aspirate of a skin mass on the hock of a cat: There is an amorphous dusky purple aggregate of extracellular material (arrow) surrounded by round to spindled cells with elongate to folded nuclei, open chromatin and light purple cytoplasm with indistinct borders (Wright's stain, 500x). In other areas of the aspirate, there were numerous plasma cells (not shown). A cytologic diagnosis of extramedullary plasmacytoma with amyloid deposition (presumptive) was made and was confirmed on histologic examination of a biopsy of the mass. The cells surrounding the presumptive amyloid are likely macrophages versus tumor cells, however smudged plasma cells can resemble histiocytes, in our experience. Macrophages were observed on histologic examination of the biopsy and diffusely infiltrated the mass. |
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Plazmocytoma, amyloid, fibroplazja The aspirate consisted of thick chunks of smooth dark purple material surrounded by cells, which varied in shape from round to spindled. The round cells had features of plasma cells with eccentric nuclei and moderate to small amounts of dark blue cytoplasm, although identification was difficult as the cells were disrupted. The spindle cells were thought to be a different population, presumptive fibroblasts associated with fibroplasia. A presumptive diagnosis of extramedullary plasma cell tumor with amyloid deposition and reactive fibroplasia was made |
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Plazmocytoma, makrofagi ze zsfagocytowanym amyloidem, fibroplazja |
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Plazmocytoma bogata w komórki Motta |
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Szpiczak mnogi, komórka 2 jądrowa |
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Histiocytoma Różnice pomiędzy Plazmocytomą, a Histiocytomą
1.Histiocytoma ma bardziej zróżnicowane kszałty jąder często wcięcia z jaśniejszą chromatyną 2.Jaśniejszą cytoplazmę, słabiej zaznaczone brzegi 3.Komórki dwujądrowe rzadko w Histiocytomach, nie ma wielojądrowch |
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Histocytoma, Keratyna - zanieczyszczenie Chromatyna rozmazana, cytoplazma jasno-niebieska, słabo widoczne granice + małe limfocyty |
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his higher power view shows the cells have round to oval to irregular nuclei (reniform nuclei is a helpful feature) with moderate amounts of cytoplasm, that lack a perinuclear clearing (Diff-quik, 1000x). Perinuclear clearing, corresponding to a Golgi area, would help differentiate this tumor from an extramedullary plasmacytoma, the main differential diagnosis in this case. Infiltrating lymphocytes are also not a typical feature of plasmacytomas. |
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Histiocytoma : There are moderate numbers of round "discrete" cells with somewhat round nuclei. The cells have a small amount of light blue cytoplasm, which has ruptured in some cells. A few cells also have a tailing appearance to the cytoplasm, but this is considered an artifact of smearing (Wright's stain, 500x). Notice the binucleated cell. Careful inspection of the cells shows that some have indented nuclei. This feature, with the lightly stippled chromatin, somewhat indistinct cytoplasmic boundaries and light cytoplasm are more consistent with a histiocytoma than a plasmacytoma. Unfortunately, no lymphocytes are present in this aspirate to steer us in the direction of a histiocytoma |
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Histiocytoma w regresji Aspirate from a raised red lesion on the eyelid of a dog: There was a mixture of cells, dominated by lymphocytes, with fewer lighter staining histiocytic cells (arrows) and neutrophils (Diff-quik, 500x). The lymphocytes were mostly small cells, although low to moderate numbers of large lymphocytes (L) were also seen. The histiocytes have oval to round to indented nuclei with coarse chromatin and a moderate amount of light cytoplasm, with somewhat indistinct boundaries. One of these cells is mitotic (M). In other areas of the smear, there were also increased numbers of neutrophils, secondary to ulceration of the mass. The results were compatible with a regressing histiocytoma. Although small lymphocytes (cytotoxic T cells) are the expected tumor-infiltrating cell associated with regression, we have seen more and more cases with variable numbers of large lymphocytes as depicted here. When the histiocytes are few in number, it can be difficult to recognize the lesion as a regressing histiocytoma (the physical description helps) and other differential diagnoses include an inflammatory lesion (e.g. secondary to a tick bite) or cutaneous lymphoma (mixed variants are seen rarely in dogs) |
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Mięsak histiocytarny - cyto mięsak 1. Komórki duże, okrągłe do wielokątnych 2. Jądra okrągłe do pleomorficznych 3. Jasno-rożowa cytoplazma, wakuolizacja 4. Część komórek 2 jądrowa/z kryteriami złośliwości CD18 (+) |
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Mięsak histiocytarny Tumor cell with a macronucleus and macronucleolus is pictured, with some intact small lymphocytes |
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The mass consists of dense aggregates of discrete round cells displaying marked anisocytosis and anisokaryosis. Cytologic features are consistent with a histiocytic sarcoma. There are also infiltrating lymphocytes, plasma cells and neutrophils |
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Mięsak Histiocytarny A neoplastic histiocyte, demonstrating features of malignancy (e.g. macronucleus), is seen amongst plasma cells and lymphocytes (likely tumor infiltrating cells) |
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Mięsak Histiocytarny The aspirate consists of numerous round cells, several of which are binucleated or multinucleated, displaying several cytologic criteria of malignancy, including marked anisokaryosis and prominent macronucleoli. The cells are dispersed in a bloody background |
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Mięsak Histiocytarny The tumor cells consist of individualized round cells with eccentric nuclei, that resemble macrophages (in this case, non-phagocytic). With this quick stain, nucleoli are quite prominent (some of which have abnormal angular shapes) and the cytoplasm is a deep blue (Diff-quik, 500x). Multinucleated and binucleated cells (some of which display intracellular anisokaryosis) can be prominent with this tumor. |
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Mięsak histiocytarny Mniejsze komórki przypominają plazmocyty ALE 1. Tu owalne, nieregularne jądra w plazmocytach okrągłe |
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Chłoniak skóry T komórkowy irate of a cutaneous plaque in a dog: Intermediate to large round cells with fine chromatin and irregular to convoluted nuclei dominate. The cells have a small amount of light blue cytoplasm. A neutrophil provides a sizing marker (the neutrophil is around the same size or can fit into the nucleus of the round cell, indicating intermediate to large cells). Since intermediate to large cells with features of lymphoid origin are the dominating cell type, the cytologic diagnosis was lymphoma. Note the cytoplasmic fragments ("lymphoglandular bodies") in the background (arrow), along with some subcutaneous fat |
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MCT, przerzut do węzła chłonnego |
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MCT Słabo widać ziarnistości. Wolne ziarnistości w tle. Jądra jednolite,chromatyna gładka. This supports a low grade tumor. With the lightly grainy cytoplasm, these cells can resemble "fried eggs" from lower magnification (they usually have abundant cytoplasm with round eccentric nuclei). |
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MCT Dużo cytoplazmy jądra okrągłe i położone mimośrodkowo The tumor cells display mild anisokaryosis, with a bilobed or potentially binucleated cell |
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MCT wo erythrophagocytic neoplastic mast cells (arrows), with many free mast cell granules, spindle cells (reactive fibroblasts) containing purple granules in their cytoplasm (presumed pinocytosed mast cell granules, arrowhead). |
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Tkanka mięśniowa - martwica dodatkowo, martwy kolagen tu akurat MCT sugeruje, że spenetrował głębsze tkanki |
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MCT A neoplastic mast cell (arrow), with fibroblasts containing purple granules (presumably from mast cells, taken up by pinocytosis, arrowheads), with necrotic cellular debris and free mast cell granules in the background |
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MCT kot There are many round or discrete cells with round nuclei and moderately blue cytoplasm. Some of the cells appear to have a perinuclear clearing and, with the color of the cytoplasm, resemble plasma cells. However, if you look carefully, you can see that several cells have numerous purple cytoplasmic granules, indicating a mast cell tumor. The cells display moderate anisokaryosis |
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TVT The cells have stippled chromatin and 1-2 nucleoli with light blue to purple cytoplasm. A mitotic figure is evident in this field |
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