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ODR
Pharm Antihistamines
14
Pharmacology
Graduate
12/13/2010

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Term
1st generation anti-histamines
Definition
PO
4-6 hour duration
AE: anticholinergic: dry mouth, constipation, sedation, alpha blocking: hypotension
Term
2nd generation anti-histamines
Definition
PO
12 hour duration
AE: tremors
loratadine, fexofenadine, terfenadine, citrizine
Term
tripelenamine: 1st or 2nd generation?
Definition
tripelenamine= 1st
Term
what drug has AE of torsades?
Definition
terfenadine (2nd gen)
Term
promethazine
Definition
used for a cold
1st generation
Term
meclizine
Definition
motion sickness (astronauts)
1st generation
Term
chrlopheniramine
Definition
1st gen
allergies
Term
dimenhydrinate
Definition
motion sickness
1st gen
Term
diphenhydramine
Definition
allergies & motion sickness
1st gen
Term
list the 1st generation anti-histamines
Definition
tripelenamine
diphenhydramine
dimenhydrinate
cholorpheniramine
meclizine
promethazine
Term
cimetedine
Definition
#1 for peptic/gastric ulcers
H2 blocker
AE: gynecomastia, blocks p450 (DIs)
Term
gynecomastia
Definition
cimetidine
Term
H2 blockers
Definition
Famotidine
Rantidine
Nizatimide
Cimetedine
Term
What drugs cause histamine release?
Definition
penicillin, narcotics (morphine), NSAIDs
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