Term
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Definition
polyene antifungals (IV or topical)
bind ergosterol in membrane>cell death
used for: candida, cryptococcus neoformans (DOC), dimorphic fungi, molds
AE: nephrotox, electrolyte wasting, infusion-related reactions |
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Term
capsofungin
micafungin
anidulafungin (degraded in plasma) |
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Definition
echinocandins
inhibit B-1,3-glucan synthase
yeasts: fungicidal
molds: pseudo-static
uses: candida, aspergillus
ineffective: cryptocooc & many molds
AE: expensive, infusion-related rxns, phlebitis, hepatotox? |
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Term
| List the Azoles and their MOA |
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Definition
| fluconazole, itraconazole, voriconazole, posaconazole, ketoconazole inhibit fungal cytP450 (decreases ergosterol formation) time-dep molds: fungicidal yeasts: fungistatic |
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Term
| What are the AEs of Azoles? |
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Definition
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Term
| What is fluconazole ineffective against? |
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Definition
| C Glabrata, C Krusei, Aspergillus, molds |
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Term
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Definition
IV/tablets/oral
treats candida, cryptococcus, some dimorphic fungi
NOT glabrata, krusei, aspergillus or molds
AE: resistance, but most-tolerated azole |
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Term
| What is the DOC for cryptococcus neoformans? |
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Definition
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Term
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Definition
capsules or oral solution
treats aspergillus, dimorphic fungi, dematiaceous molds, yeasts: candida and cryptococcus
AE: diarrhea, negative inotrope (C/I in CHF), drug interactions |
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Term
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Definition
|
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Term
| What treats dematiaceous molds? |
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Definition
|
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Term
| What is the DOC for invasive aspergillus? |
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Definition
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Term
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Definition
IV & oral solution
non-linear PK
DOC for invasive apergillus
also treats yeasys: candida, cryptococc
molds: aspergillus, fusarium, scedosporium
endemic fungi, demataceous molds
AE: visual effects, hallucinations, hepatotox, low conc may fail, high conc may be toxic |
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Term
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Definition
PO only, best absorbed w/high fat meal
used for yeasts: candida and cryptococc, molds: aspergillus and zygomycetes |
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Term
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Definition
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Term
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Definition
an antimetabolite
deaminated in fungal cells to 5FU>replaces uracil>stops RNA & DNA synthesis
Treats candida, cryptococc neoformans, crypto meningitis, less active against c kruseii, some activity against aspergillus and other molds
AE: BM suppression, GI intolerance, rash, hepatotox |
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Term
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Definition
allyamine; inhibits squalen epoxidase (prevents synthesis of ergosterol)
oral & topical
nails, fat, skin
clinically used for dermatophytes (onchomycosis), also active against candida, aspergillus
AE: hepatotox, neutropenia, stevens-johnson syndrome |
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Term
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Definition
inhibits fungal mitosis via interaction w/microtubules
taken orally
used for onchomycosis but not preferred (active against dermatophytes)
AE: CNS (mainly headache) |
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