Term
| How is vasculitis diagnosed? |
|
Definition
| biopsy of tissue shows damaged and inflamed BVs |
|
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Term
|
Definition
temporal artertis
affects large vessels w/elastic laminae
Sx: headache, scalp paresthesias/tenderness, jaw claudication, leg claudication, ^ESR, pain in arms/legs & morning stiffness, blindness |
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|
Term
| What is the most common group of people affected by giant cell arteritis? |
|
Definition
|
|
Term
| How is giant cell arteritis treated? |
|
Definition
|
|
Term
|
Definition
large & medium sized vessels
M>W
multisystem disease: ischemia of organs (i.e. mesentary>abd pain & bloody stools)
mononeuritis multiplex
skin nodules/necrosis
glomerular involvement: renal insuff
tx: more agressive |
|
|
Term
| vasculitis associated w/abd pain and bloody stools |
|
Definition
| polyarteritis nodosa (mesenteric ischemia) |
|
|
Term
| What vasculitis is caused by drugs? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
medium-sized vessels
lung, sinuses, URT, kidney
limited wegener's affects 1 organ system |
|
|
Term
| How is Wegener's granulomatosis treated? |
|
Definition
| steroids and cyclophosphamide |
|
|
Term
| What diseases mimic vasculitis? |
|
Definition
endocarditis
atrial myxoma
chol embolization
thromboangitis obliterans |
|
|
Term
| scalp paresthesia/tenderness |
|
Definition
|
|
Term
|
Definition
| polymyositis + rash on face, chest, eyelids (gottren's papules) |
|
|
Term
|
Definition
dermatomyositis
rash on face, chest, eyelids |
|
|
Term
| clinical presentation of inflamm muscle diseases |
|
Definition
prox muscle weakness: very little pain
^ muscle enzymes
abn EMG
abn muscle biopsy
skin: rash on sun-exposed areas
periungual telangiectasias
heliotrope: discoloratin of eyelids with or without edema
calcinosis |
|
|
Term
| progressive systemic sclerosis |
|
Definition
thickening and tightening of the skin
spreads from distal extremities up arms/legs |
|
|
Term
| What is seen in biopsy of progressive systemic sclerosis? |
|
Definition
fibrosis of skin
^collagen deposition
intimal thickening/narrowing of BVs |
|
|
Term
| What other conditions are associated w/progressive systemic sclerosis? |
|
Definition
raynaud's
esoph dysmotility
ANA antibodies |
|
|
Term
|
Definition
keratoconjuctivitis sicca
hypergammaglobulinemia
parotid gland swelling
inflamm polyarthritis
lymphadenopathy
pesudolymphoma
Dx: savliary gland biopsy, SSA & SSB antibodies |
|
|
Term
| Limited Cutaneous Disease |
|
Definition
Calcinosis
Raynaud's
Esophageal dysmotility
Sclerodactaly or limited tightening in face
telangiectasias
usually benign except severe pulm HT |
|
|
Term
| Internal organ damage from scleroderma |
|
Definition
renal failure
malignant HT
digital ischemia>gangrene
pulm fibrosis
pulm HT
malabs
polymyositis
arthritis |
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