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Odontogenic Tumors
path exam 1
84
Pathology
Graduate
02/12/2017

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Term
Clinical features of ameloblastoma
Definition
Age: 40 yrs
Mandible molar ramus area
Asymptomatic expansion
M=F
Term
Where do you find ameloblastomas?
Definition
mandible molar ramus area
Term
Radiographic features of ameloblastomas
Definition
Uni or multilocular radiolucency
Patterns: "soap bubble", "honey comb"
Root resorption
Sclerotic margins
Term
Microscopic features of ameloblastomas
Definition
Microscopic diagnostic criteria: nuclear palisading, reverse polarization, hyperchromatism and cytoplasmic vacuolization of basal cells

Patterns: most common are follicular and plexiform
Term
Differential diagnosis of ameloblastomas
Definition
Lateral periodontal cyst (unilocular), myxoma, dentigerous cyst, OKC, ameloblastic fibroma, central giant cell lesion, ABC, central hemangioma
Term
Treatment for ameloblastomas
Definition
marginal resection, resection
Term
Clinical features of unicystic ameloblastomas
Definition
Age: 2nd to 3rd decades
Typically in mandibular molar area
< 10% recurrence when curettage is 1° treatment
Term
Where do you find unicystic ameloblastomas?
Definition
mandibular molar area
Term
Radiographic features of unicystic ameloblastomas
Definition
radiolucency associated with impacted third molar
Term
Microscopic features of unicystic ameloblastomas
Definition
Cyst lined by ameloblastic epithelium
Term
Differential diagnosis of unicystic ameloblastomas
Definition
dentigerous cyst, OKC
Term
Treatment for unicystic ameloblastomas
Definition
Enucleation and close follow-up
Term
Clinical features of calcifying epithelial odontogenic tumor (CEOT)
Definition
Mean age: 40 yrs.
M=F
Painless, slow growing
Most common in mandible (molar/premolar area)
Often associated to an impacted tooth
Term
Where do you find CEOT?
Definition
mandible (molar/premolar area)
Term
Radiographic findings of early stage CEOT?
Definition
uni or multilocular radiolucency associated to an impacted tooth. Root resorption
Term
Radiographic findings of late stage CEOT?
Definition
Uni or multilocular with radiopacities around the crown of an
impacted tooth
Term
Microscopic features of CEOT
Definition
Large polygonal epithelial cells with eosinophilic cytoplasm and nuclei of various sizes.

Amyloid

Liesegang rings
Term
Differential diagnosis of radiolucent CEOT
Definition
dentigerous cyst, ameloblastoma, OKC, myxoma
Term
Differential diagnosis of mixed radiolucent/radiopaque CEOT
Definition
COT, AOT, ameloblastic fibro-odontoma, ossifying fibroma, osteoblastoma
Term
Treatment for CEOT
Definition
conservative local resection with a rim of normal tissue. Recurrence rate less than 20%
Term
Clinical features of adenomatoid odontogenic tumor (AOT)
Definition
Age: Most cases in the 2nd decade
F:M (2:1)
Painless, enlargement of the maxillary lateral incisor - canine
area
More common in maxilla (64%)
Term
Where do you find AOT?
Definition
maxillary lateral-incisor area (more common in maxilla)
Term
Radiographic features of AOT
Definition
Well-circumscribed, unilocular
pericoronal area of an impacted tooth

RL + / - RO (snowflake)

Divergence of teeth is possible
Term
Microscopic features of AOT
Definition
Intracystic rosettes and duct-like structures of columnar epithelial cells
Term
Differential diagnosis of AOT if calcified
Definition
CEOT, COC
Term
Differential diagnosis of AOT if non-calcified
Definition
lateral radicular cyst, dentigerous cyst, ameloblastic fibroma
Term
Treatment for AOT
Definition
enucleation
Term
Clinical features of odontogenic myxoma
Definition
Mean age: 30 yrs
More common in mandible
Asymptomatic expansion
M=F
Term
Radiographic features of odontogenic myxoma
Definition
Uni or multilocular radiolucency
Pattern: "Soap bubble", "step ladder"
Root resorption
Sclerotic margins
Term
Microscopic features of odontogenic myxoma
Definition
Haphazardly arranged stellate, spindle shaped cells amidst a loose, myxomatous matrix with sparse collagen fibrils
Term
Differential diagnosis of odontogenic myxoma if unilocular radiolucency not between roots
Definition
Hyperplastic follicle, ameloblastic fibroma, dentigerous cyst, AOT, OKC, COC
Term
Differential diagnosis of odontogenic myxoma if unilocular radiolucency between roots
Definition
OKC, lateral periodontal cyst
Term
Differential diagnosis of odontogenic myxoma if multilocular radiolucencies
Definition
Ameloblastoma, central giant cell L, OKC, ameloblastic fibroma, COC, central hemangioma, ABC
Term
Treatment for odontogenic myxoma for small lesions
Definition
curettage and close follow-up for at least 5 years
Term
Treatment for odontogenic myxoma for large lesions
Definition
En bloc resection
Term
Clinical features of central odontogenic fibroma (COF)
Definition
Mean age: 40 yrs.
F:M (2:1)
Most maxillary lesions are anterior to first molars
Most mandibular lesions are posterior to mandibular molars
One third associated to an unerupted tooth
Term
Radiographic findings for small COF and large COF
Definition
small: asymptomatic unilocular and often associated to periradicular area

large: both expansion and loosening of teeth

Sclerotic border, root resorption and divergence. Radiopaque flecks in 12%
Term
Microscopic features of COF
Definition
Collagenous background with few fibroblasts and islands of odontogenic epithelium
Term
Differential diagnosis of COF for small unilocular periradicular radiolucency
Definition
radicular cyst
Term
Differential diagnosis of COF for small unilocular radiolucency associated to impacted tooth
Definition
dentigerous cyst
Term
Differential diagnosis of COF for multilocular radiolucencies
Definition
ameloblastoma, central giant cell L., OKC, ameloblastic fibroma, COC, central hemangioma, ABC
Term
Treatment for COF
Definition
Enucleation and curettage. Recurrence is uncommon
Term
Clinical features of cementoblastoma
Definition
Age: 20- 30 yrs.
More common in posterior mandible
M=F
Cortical expansion and occasionally intermittent pain
Term
Where do you find cementoblastomas?
Definition
posterior mandible
Term
Radiographic findings of cementoblastoma
Definition
Radiopacity surrounded by radiolucent rim associated with the root of a tooth
Term
Microscopic findings of cementoblastoma
Definition
Mass of mineralized cementum-like material with intervening vascularized stroma containing numerous large and hyperchromatic cementoblasts
Term
Differential diagnosis for cementoblastoma
Definition
Odontoma, hypercementosis, focal sclerosing osteomyelitis, osteoblastoma
Term
Treatment for cementoblastoma
Definition
Surgical extraction of the tooth along with the attached mineralized mass. No recurrence after complete removal
Term
Clinical features of odontoma
Definition
Mean Age: 14 yrs
Most occur in the second decade
Compound odontoma more common in maxilla
Complex odontoma more common in mandible
Term
Where do you find compound odontoma?
Definition
maxilla
Term
Where do you find complex odontoma?
Definition
mandible
Term
Radiographic features of compound odontoma
Definition
Radiopacities with a tooth-like appearance surrounded by
a radiolucent rim
Term
Radiographic features of complex odontoma
Definition
Calcified mass with a radiolucent rim.
Term
Microscopic features of compound odontoma
Definition
Dental tissues displaying a tooth-like appearance (denticles)
Term
Microscopic features of complex odontoma
Definition
Dental tissues with a haphazard configuration
Term
Differential diagnosis for compound odontoma
Definition
diagnostic features
Term
Differential diagnosis for complex odontoma
Definition
Osteoma, cementoblastoma, idiopathic osteosclerosis, ossifying fibroma, calcifying odontogenic tumor, ABC
Term
Treatment for odontomas
Definition
simple local excision
Term
Clinical features of ameloblastic fibroma
Definition
Age: First two decades of life
M=F
70% occur in the mandible
Small tumors are asymptomatic
Large tumors produce expansion
75% of cases are associated with an unerupted tooth
Term
Where do you find ameloblastic fibromas?
Definition
mandible
Term
Radiographic features of ameloblastic fibromas
Definition
Unilocular (small) or multilocular (large) radiolucencies with well defined sclerotic borders
Term
Microscopic features of ameloblastic fibromas
Definition
Mesenchymal tissue with the appearance of dental papilla. In addition, cords of odontogenic epithelium composed of cuboidal to columnar basal cells
Term
Differential diagnosis of ameloblastic fibromas of typical demographics and radiographic pattern
Definition
diagnosis is apparent
Term
Differential diagnosis of ameloblastic fibromas of atypical demographics and radiographic pattern
Definition
Ameloblastoma, odontogenic myxoma, dentigerous cyst, OKC, central giant cell lesion, histiocytosis
Term
Treatment for ameloblastic fibroma
Definition
Enucleation

Recurrences range from 0-43.5%

Aggressive surgical excision for recurrent lesions.

Ameloblastic fibrosarcoma may arise de novo or in a recurrent ameloblastic fibroma
Term
Clinical features of ameloblastic fibro-odontoma
Definition
Mean age= 10 yrs.
M=F
Most occur in the posterior mandible
Asymptomatic
Large tumors produce expansion
Most cases are associated with an unerupted tooth
Term
Where do you find ameloblastic fibro-odontoma
Definition
posterior mandible
Term
Radiographic features of ameloblastic fibro-odontoma
Definition
Unilocular or multilocular radiolucencies with well defined sclerotic borders and variable amounts of calcified material
Term
Microscopic features of ameloblastic fibro-odontoma
Definition
Identical to ameloblastic fibroma. In addition, calcified material consistent with dentin, enamel, and enamel matrix arranged in toothlike patterns or as haphazard masses
Term
Differential diagnosis of radiolucent ameloblastic fibro-odontoma
Definition
dentigerous cyst, myxoma, OKC, central giant cell lesion, ameloblastoma, histiocytosis
Term
Differential diagnosis of radiolucent/radiopaque ameloblastic fibro-odontoma
Definition
Calcifying epithelial odontogenic tumor, calcifying epithelial odontogenic cyst, odontoma, adenomatoid odontogenic tumor
Term
Treatment for ameloblastic fibro-odontoma
Definition
Curettage. Recurrence is extremely rare after complete
removal
Term
Which tumor(s) are associated with the radiographic feature "soap bubble" pattern
Definition
odontogenic myxoma, ameloblastoma
Term
What is the most common odontogenic tumor?
Definition
odontoma
Term
What is the second most common odontogenic tumor?
Definition
ameloblastoma
Term
If unilocular pericoronal radiolucency, what is the differential diagnosis? (think cysts and/or tumors)
Definition
Hyperplastic follicle, dentigerous cyst, OKC, ameloblastic fibroma, AOT, COC
Term
If unilocular radiolucency between roots, what is the differential diagnosis? (think cysts and/or tumors)
Definition
OKC, lateral periodontal cyst
Term
If multilocular radiolucency, what is the differential diagnosis? (think cysts and/or tumors)
Definition
Odontogenic myxoma, OKC, calcifying odontogenic cyst, ameloblastic fibroma, central giant cell L., ABC, central hemangioma
Term
Clinical features of squamous odontogenic tumors (SOT)
Definition
Equal frequency of anterior maxilla and posterior mandible
Mean age = 40 yrs
Asymptomatic expansion
M=F
Multiple lesions: 20% of affected pts
Term
Microscopic features of SOT
Definition
Dental lamina rests (rests of Serres)
Epithelial rests of Malaise
It appears to originate within the PDL
Islands of bland-appearing squamous epithelium with micro cyst formation
Term
Radiographic features of SOT
Definition
triangular radiolucent lesion
Term
Treatment for SOT
Definition
Local excision or curettage
Term
What has scalloping? (tumors or cysts)
Definition
Odontogenic myxoma, traumatic bone cyst
Term
Recurrence rate of cementoblastoma
Definition
No recurrence (after complete removal)
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