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Odontogenic Tumors
Odontogenic tumors
25
Pathology
Graduate
04/24/2013

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Term
what is an Ameloblastoma?
Definition
-benign, slow growing epilthelial tumor
-comes fromr esidual epiltheliu from tooth develpment
-unencapsulated and invasive, can result in death
Term
Where are ameloblastomas commonly seen? What do they cause? What are they associated with? How do they appear radiographically?
Definition
-80% arise in mandible and most of those in posterior region
-Causes expansion of bone, slowly and asymptomatic -can lead to facial deformity
-Frequently associated with an impacted tooth and in association with a dentigerous cyst
-Radiographically can appear as a unilocular or multilocular (soap-bubble) radiolucency
Term
How are ameloblasteomas treated? What do they penetrat? Are lesions hard to define? Are they easy to treat?
Definition
-Treatment –surgical removal (wide excision with resection)
-Ameloblastoma has a tendency to penetrate adjacent trabecular spaces –but don’t show evidence radiographically
-Lesion’s boundaries hard to determine
-Lesion resistant to radiation and chemotherapy
-Recurrence common (50%)
Term
Where else can ameloblastomas occur? What are they called then? What is the treatment? Do these recur?
Definition
-Can occur in the gingiva only
-Called peripheral ameloblastoma
-Treatment –surgical removal
-Do NOT tend to recur
Term
What is a Calcifying Epithelial Odontogenic Tumor also known as? What do they originate from? What are they clinically similar to?
Definition
-Also known as the “Pindborg tumor”
-Originates from remanents of the REE or dental lamina
-Deposits of an amyloid type substance seen with calcifications in these deposits
-Clinically is similar to the ameloblastoma
Term
How do Calcifying Epithelial Odontogenic Tumor appear radiographically? Treatment? Recurrence?
Definition
-Radiographically appears as a unilocular or multilocular radiolucency with scattered radiopacities of abnormal enamel “driven snow”
-Treatment –since can be locally invasive and is unencapsulated, wide surgical excision
-Recurrence rate lower than for ameloblastoma
Term
What is a Adenomatoid Odontogenic Tumor Odontogenic Adenomatoid Tumor (OAT)? Why is it called that? What forms in the center of these structures?
Definition
-Encapsulated, benign epithelial tumor
-Called “adenomatid” because ameloblast-like cells form structures that look like ducts
-Calcifications also form in eosinophilic material that forms in the center of these structures
Term
What are OAT's like clinically? What are they associated with? What may you see with these? Who are they seen in? Where?
Definition
-Clinically, most are asymptomatic
-Often associated with impacted teeth
-May see localized swelling
-70% seen in adolescent girls
-70% involve the
Term
What do OAT's look like radiographycally? What may form within the tumor? What is the treatment for these?
Definition
-Radiographically appear as a well-circumscribed radiolucency often involving the crown and can involve the root (up to 50%)
-Calcifications may form within the tumor
-Treatment –surgical removal, easily separates, recurrence rare
Term
What are Calcifying Odontogenic CystGorlin Cyst lined with? What do they resemble? What kind of cells are seen? Who are these seen in?
Definition
-Cystic lesion lined by odontogenic epithelium
-Epithelium resembles ameloblasts & stellate reticulum
-Ghost cells seen (round structures with clear centers) and calcifications can occur
-Clinically seen in young individuals as a localized swelling often in the anterior region
Term
How do gorlin cysts appear radiographically? Is the solid varient safer? What is the treatment?
Definition
-Radiographically appears as a well-defined unilocular or multilocular radiolucency with scattered radiopacities “salt and pepper”
-Solid variant is more aggressive and considered a neoplasm
-Treatment –surgical removal, solid lesions more extensively
Term
What are some examples of Mesenchymal Odontogenic Tumors? (3)
Definition
-Odontogenic Myxoma
-Central Cementifying and Ossifying Fibromas
-Cementoblastoma
Term
What is a Odontogenic Myxoma? What is it composed of? How does it appear clinically?
Definition
-Benign, nonencapsulated infiltrating lesion
-Composed of a mucoid ground substance with cells that have long cytoplasmic processes called myxoblasts that resembles tissue seen in the dental papilla
-Clinically most are slowly enlarging swellings, painless, in either maxilla or mandible
Term
Who are Odontogenic Myxomas seen in? How do they appear radiograohically? How are they treated?
Definition
-Seen in young people (under 30)
-Radiographically appear as a multilocular radiolucency “soap bubble” or “honeycomb” -margins not well demarcated
-Treatment –complete surgical removal, block resection, recurrence rate 25%
Term
What are Cementifying and Ossifying Fibromas? What are they composed of? How do they appear clinically?
Definition
-Benign, well-circumscribed tumors
-Composed of fibrous connective tissue and calcifications resembling either cementum or bone
-Clinically seen in young adults as an asymptomatic swelling
Term
How do Cementifying and Ossifying Fibromas appear radiographically? What is their treatment?
Definition
-Radiographically appears as a well defined radiolucent to radiopaque lesion
-Treatment –surgical removal, easily separate, recurrence is rare
Term
What are Cementoblastomas? How do they appear clinically? Where do they occur? What age?
Definition
-Benign, well-circumscribed neoplasm of cementum
-Clinically seen attached to the apical 1/3 of the root
-Most occur in the premolar/molar area
-Peak incidence is 19 years
-Expand the buccal and lingual cortical plates
Term
Does the tooth remain vital with a cementoblastoma? What is unique about them? How do they appear radiographically?
Definition
-Teeth remain vital
-Unique in that PAIN is associated with it
-Radiographically appears as a unilocular well-demarcated, radiopaque or radiolucent or mixed
Term
How does the PDL look with Cementoblastomas? What do the adjacent roots exhibit? WHat is the treatment?
Definition
-PDL space looks normal
-Adjacent roots may exhibit resorption
-Treatment –surgical removal along with tooth
Term
What is a Ameloblastic FibromaAmeloblastic Fibro-odontoma? WHat do they mimec?
Definition
-Benign, nonencapsulated tumor characterized by neoplastic proliferation of both epithelium and mesenchyme
-Epithelial component can mimic ameloblastoma but less aggressive
Term
Who are Ameloblastic Fibroma Ameloblastic Fibro-odontomas commonly found in? Where?
Definition
-Most found in the young, asymptomatic
-Posterior mandible most common
Term
How do Ameloblastic FibromaAmeloblastic Fibro-odontomas appear radiographically? Treatment? Recurence rate?
Definition
-Radiographically radiolucency, Fibro-odontoma has calcifications within also
-Treatment –surgical removal, -recurrence rate 18%
Term
What is an Odontoma? What are the 2 types?
Definition
-Benign tumor of enamel, dentin, cementum, and pulp
-Two types: Compound odontoma and Complex odontoma
Term
What does a compound Odontoma consist of? complex?
Definition
-Compound consists of a collection of small teeth
-Complex consists of a mass of tissue
Term
How do odontomas appear radiographically? Treatment?
Definition
-Appear radiographically as a cluster of small teeth or a radiopaque mass surrounded by a halo
-Treatment –surgical removal, do not tend to recur
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