Term
Pathogenic Gram-Positive Cocci and Bacilli |
|
Definition
Stain purple when gram-stained |
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|
Term
Staphylococcus is a _____ member of every human’s microbiota. |
|
Definition
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|
Term
Staphylococcus is located: |
|
Definition
In nasopharynx On skin Colonizes the infant w/in hours |
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|
Term
Staphylococcus found in hospitals in |
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Definition
Nurseries and surgical wards. |
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|
Term
Staphylococci live and reproduce on |
|
Definition
almost every square inch of human skin |
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Term
Staphpylococcus can be ______ pathogens causing anywhere from minor to life threatening diseases |
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Definition
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Term
Staphylococcus genus name comes from Greek term staphle meaning ______ |
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Definition
|
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Term
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Definition
spherical–shaped bacterial cell |
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Term
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Definition
staff or group (Cluster like grapes) |
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|
Term
Staphylococcus colonies appear |
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Definition
cream colored, white to light gold, and “buttery-looking” |
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|
Term
Staphylococcus is Gram _____ |
|
Definition
positive cocci, nonmotile, facultative anaerobes |
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Term
Staphylococcus grows best when _____ present, but can continue to grow under ____ conditions. |
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Definition
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|
Term
Staphylococcus is _____-tolerant |
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Definition
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|
Term
Staphylococcus tolerates the ____ present on human skin |
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Definition
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Term
Staphylococcus is tolerant of desiccation (capsule). What does this mean? |
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Definition
allows survival on environmental surfaces such as fomites Object inadvertently used to transfer pathogen to new host: needle or coin |
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Term
Staphylococci are catalase positive or negative? |
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Definition
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|
Term
Catalase Converts H202, (hydrogen peroxide) Into_____ and ____? |
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Definition
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|
Term
Staphylococci can disarm neutrophil’s and macrophage’s H2O2 with ______? |
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Definition
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|
Term
_______ is secreted by neutrophils and macrophages to kill bacteria |
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Definition
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Term
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Definition
Inoculating loop is rubbed across a colony of Staphylococcus and mixed with H202 on a slide. If bubbles appear, the enzyme catalase must be present. So Staphylococcus is catalyst positive |
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Term
Staphylococcal infections range from the |
|
Definition
trivial to the rapidly fatal |
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|
Term
Are Staphylococcal infections easy to treat? |
|
Definition
No, They can be difficult to treat |
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|
Term
Why are Staphylococcal infections difficult to treat? |
|
Definition
Because staphylococci can acquire antibiotic resistance |
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|
Term
“Staph” infections result when staphylococci |
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Definition
breach the body’s physical barriers. |
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|
Term
Entry of only a few hundred bacteria (ID) can result in |
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Definition
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|
Term
Staphylococci are ______ in nature with about a _____ species part of our human flora |
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Definition
|
|
Term
How many species are commonly associated with staphylococcal diseases in humans? |
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Definition
|
|
Term
What are the 2 species commonly associated with staphylococcal diseases in humans? |
|
Definition
1.Staphylococcus aureus is one of the most common causes of infections 2.Less virulent,opportunist Staphylococcus epidermis may cause prosthetic implant infections |
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|
Term
Staphylococcus aureus is one of the most common causes of |
|
Definition
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|
Term
Less virulent, opportunist Staphylococcus epidermis may cause |
|
Definition
prosthetic implant infections |
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|
Term
Staphylococcus epidermidis is the______ of human skin |
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Definition
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|
Term
Staphylococcus epidermidis is the normal microbiota of human skin that can cause ? |
|
Definition
opportunistic infections to immunocompromised patients or when introduced into parts of body |
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|
Term
Staphylococcus aureus is located on |
|
Definition
skin, nares, mucous membranes (pharynx and vagina) |
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|
Term
What pigment is Staphylococcus aureus on sheep blood agar? |
|
Definition
|
|
Term
Pathogenicity of Staphylococus (3 things) |
|
Definition
1.Cell wall structures that prevent phagocytosis 2. Enzymes 3. Production of toxins |
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|
Term
Cell wall structures that prevent phagocytosis (3 things) |
|
Definition
a. Protein A b. Bound coagulase c. Capsule/slime layer |
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Term
|
Definition
a. Coagulase b. Staphylokinase c. Hyaluronidase d. Lipase e. B-lactamses |
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|
Term
|
Definition
a. Cytolytic toxins b. Exfoliative toxins c. Toxic-shock-syndrome (TSS) toxin d. Enterotoxins |
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|
Term
Staphylococcus aureus has Protein A which causes_____to bind upside-down _____ antigen. This _____ opponization and ________. |
|
Definition
antibody stems,S. aureus Inhibits, phagocytosis |
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Term
Staphylococcus aureus has ________ that converts fibrinogen into ______ that form clots around pathogen. |
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Definition
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|
Term
Fibrin clots ______ Staphylococcus aureus from phagocytic cells |
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Definition
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|
Term
Staphylococcus aureus forms slime layer/capsule that prevents: |
|
Definition
Phagocytosis and Dessiccation |
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|
Term
Slime layer facilitates attachment of Staphylococcus to artificial surfaces such as (5 things) |
|
Definition
catheters, shunts, artificial heart valves and joints |
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Term
Coagulase triggers fibrin clotting, which hides the _______ |
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Definition
|
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Term
|
Definition
Dissolves fibrin threads in clots, allowing S.aureus to free itself from clots and spread to new location |
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Term
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Definition
Breaks down hyaluronic acid, enabling S. aureus spread deeper between cells |
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|
Term
|
Definition
digest lipids allowing Staphylococcus aureus to grow on surface of skin and sebaceous glands |
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Term
|
Definition
penicillinase now in 90% of S. aureus strains and thus resistant to penicillin and cephalosporins |
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Term
Cytolytic toxins Disrupts the ______ ______ ______of a variety of cells such as |
|
Definition
mammalian cytoplasmic membrane Heart, skeletal muscle, renal cells, platelets |
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Term
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Definition
|
|
Term
|
Definition
Leukocytes, Macrophages, and neutrophils |
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|
Term
Leukocidin provides S. aureus ______ from _____. |
|
Definition
protection from phagocytosis |
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|
Term
Exfoliative toxins = ET causes |
|
Definition
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|
Term
Exfoliative toxin dissolves |
|
Definition
desmosomes The patient’s epidermal layer of skin to slough off |
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|
Term
Toxic-shock-syndrome toxin symptoms |
|
Definition
High fever, rash, peeling of skin, vasodilation, drop in BP |
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|
Term
Staphylococcus aureus produces enterotoxin proteins which in turn stimulate which 4 things? |
|
Definition
Intestinal muscle contractions Nausea Intense vomiting Associated with staphylococcal food poisoning |
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|
Term
Staphylococcus aureus Enterotoxins are ____ stable |
|
Definition
|
|
Term
Heat does not denature_____ protein |
|
Definition
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|
Term
cover dish dinner; take home leftovers; reheat = zap in microwave. This process Does not _______the Enterotoxin |
|
Definition
|
|
Term
Staphylococcal Diseases categorized as which 3 things? |
|
Definition
1. Noninvasive Disease 2. Cutaneous Disease 3. Systemic Disease |
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|
Term
|
Definition
Food poisoning Ingestion of Staphylococcus aureus contaminated food |
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|
Term
Ingestion of Staphylococcus aureus contaminated food Bacteria grow on food and secretes |
|
Definition
Enterotoxin that is heat stable |
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|
Term
Common cause of food poisoning? |
|
Definition
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|
Term
Food poisoning is caused by ______ rather than by ______ of the bacteria |
|
Definition
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|
Term
Food must remain at ________for several hours for bacteria to grow, reproduce, and produce toxin |
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Definition
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|
Term
Enterotoxin causes ____, ____, ____ for how long? |
|
Definition
nausea, vomiting, diarrhea for 24 hours |
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|
Term
Reheating may kill ______ bacteria but does not inactivate _______. |
|
Definition
|
|
Term
2. Cutaneous Disease Various skin conditions: name 6 |
|
Definition
Scalded skin syndrome Impetigo Folliculitis Sty Furuncles Carbuncle |
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|
Term
Staphylococcus aureus causes localized _______(pus filled lesions)lesions |
|
Definition
|
|
Term
|
Definition
|
|
Term
Scalded skin syndrome = Exfoliative toxin causes: name 4 things |
|
Definition
Reddening of skin Large blisters Epidermis peels off in two days Subject to secondary bacterial infection |
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|
Term
Scalded skin syndrome = Exfoliative toxin Usually affects ______ of severed umbilicus & Older children with ______. |
|
Definition
neonates, skin infections |
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|
Term
Staphylococcus aureus causes 80% of |
|
Definition
|
|
Term
impetigo is what and occurs on who? |
|
Definition
Small, flattened, red patches on face, limbs of children whose immune system is not fully developed |
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|
Term
impetigo mostly occurs on _____ as pus filled vesicles that crust over and become honey colored, wet, flaky. The pus is filled with ____ and ____ |
|
Definition
|
|
Term
|
Definition
Infection of hair follicle |
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|
Term
Folliculitis Becomes red, swollen, and pus filled. When it occurs at base of eye in eyelash follicle it is called a |
|
Definition
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|
Term
Furuncle = boil Penetrates into the ______? |
|
Definition
Large, painful, raised nodular extension of folliculitis to surrounding tissue. Penetrates into the subcutaneous layer |
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|
Term
|
Definition
several furuncles coalesce |
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|
Term
|
Definition
Larger, deeper, more painful May have to be surgically drained Can be the size of baseball |
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Term
Carbuncle May cause____ and _____ as S. aureus spreads into underlying tissues may need ______. |
|
Definition
fever, chills, antibiotics |
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|
Term
S. aureus can cause a variety of potentially fatal _____ _____ When introduced to deeper tissues of the body such as ___, ____, ____, and ____. |
|
Definition
systemic infections Blood, heart, lungs, and bones |
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|
Term
3. Systemic Disease 6 things |
|
Definition
TSS Pneumonia Bacteremia Endocarditis Osteomyelitis Empyema |
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|
Term
Staphylococcus aureus produce _____ toxin |
|
Definition
|
|
Term
Staphylococcus aureus can grow in a _____ or _____ vagina and produce the toxin and cause______. |
|
Definition
wound,abraded Toxic shock syndrome |
|
|
Term
can TSS occur in both males and females? |
|
Definition
|
|
Term
Toxic Shock Syndrome Toxin causes: |
|
Definition
Fever Vomiting and Diarrhea Red rash Loss of sheets of skin Low BP, shock Multi-organ failure due to shock |
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|
Term
TSS fatal in ____% cases. Why? |
|
Definition
5%, When BP drops so low O2 cannot be carried to vital organs and causes shock, death |
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|
Term
Staphylococcus aureus in blood is ______ and Accounts for half of all ______ infections |
|
Definition
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|
Term
Staphylococcus aureus Bacteremia Causes: |
|
Definition
Furuncles Vaginal infections Infected surgical wounds |
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|
Term
Hospitalized patients with chronic disease that contract S. aureus bacteremia have a |
|
Definition
|
|
Term
Staphylococcus aureus = Endocarditis |
|
Definition
Attacks lining of heart and valves |
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|
Term
Endocarditis is one of the consequences of _______. |
|
Definition
staphylococcal bacteremia |
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|
Term
Staphylococcus aureus = Endocarditis Symptoms are _____ and ______. |
|
Definition
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|
Term
Staphylococcus aureus = Endocarditis Blood pumped from heart ______ which in turn makes the ____ drop. 50% patients do not |
|
Definition
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|
Term
Staphylococcus aureus in blood invades _____ causing______. |
|
Definition
|
|
Term
Mortality rate for staphylococcal pneumonia is _____%. |
|
Definition
|
|
Term
Staphylococcal pneumonia known to occur as secondary infection to |
|
Definition
|
|
Term
Staphylococcal pneumonia Particularly occurs in _____ and_______ patients |
|
Definition
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|
Term
In 10% of patients with Staphylococcal pneumonia… The fluid filling the alveoli is _____, this condition is called ______. |
|
Definition
|
|
Term
When Staphpylococcus aureusInvades a bone, it causes |
|
Definition
Staphylococcal osteomyelitis |
|
|
Term
Staphylococcal osteomyelitis Signs and symptoms are: Inflammation of |
|
Definition
Bone marrow, diaphysis and periosteum Fever, Chills, Swelling and pain (Brake hip and get stahpylococcus aureus infection in bone) |
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|
Term
Diagnosis of Staphylococcus Infections |
|
Definition
Detection of Gram-positive bacteria Isolated from pus, blood, or other fluids |
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|
Term
Treatment: ______ is the drug of choice to treat staphylococcal infections. |
|
Definition
|
|
Term
Treatment:Since (1962) 1987 have: MRSA = |
|
Definition
methicillin-resistant Staphylococcus aureus |
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|
Term
Treatment: Since 2002 have: VRSA = |
|
Definition
vancomycin resistant S. aureus |
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|
Term
Prevention = some humans are carriers |
|
Definition
Hand antisepsis Proper cleansing of wounds and surgical openings Aseptic use of catheters or indwelling needles Appropriate use of antiseptics |
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|
Term
The Genus Streptococcus Is a diverse group of |
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Definition
|
|
Term
Streptococcus can be arranged in ____ or ______ |
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Definition
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|
Term
Streptococcus are arranged in pairs called |
|
Definition
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|
Term
Streptococcus are Arranged in chains like a strip of button candy called |
|
Definition
|
|
Term
Streptococcus is Catalase _____ |
|
Definition
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|
Term
Most Streptococcus are _______ ________. |
|
Definition
|
|
Term
Serological classification of Streptococcus is useful in _______. |
|
Definition
|
|
Term
The Lancefield classification Developed by Rebecca Lancefield in 1938 was Based on ______ ______. |
|
Definition
serological classification |
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|
Term
The Lancefield classification puts various strains of Streptococcus into _____ different groups. |
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Definition
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|
Term
Lancefield groups go from _____ to ____. |
|
Definition
|
|
Term
Lancefield groups A and B are ______ and ______. |
|
Definition
|
|
Term
GAS and GBS Include the significant streptococcal pathogens of _____. |
|
Definition
|
|
Term
There are _____ species of Streptococci only a few (5) are ______ _______. |
|
Definition
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|
Term
|
Definition
|
|
Term
What do Group A (GAS) Streptococcus pyogenes look like? |
|
Definition
Looks like chain of purple pearls on slide |
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|
Term
Group A Streptococcus: GAS On blood agar plate, Streptococcus pyogenes forms ______ colonies surrounded by _____ of beta-hemolysis on blood agar plates. |
|
Definition
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|
Term
Streptococcus pyogenes lyse _____ leaving a ____ zone around ____ colony. |
|
Definition
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|
Term
What is the main representative of group A Streptococcus (GAS)? |
|
Definition
|
|
Term
What is the most serious streptococcal pathogen? |
|
Definition
|
|
Term
Streptococcus pyogenes has a number of Structures, Enzymes and Toxins that enable it to survive as a ______. |
|
Definition
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|
Term
Pathogenic strains of Streptococcus pyogenes form _____ |
|
Definition
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|
Term
What are the structural components and enzymes of Streptococcus pyogenes? 5 things? |
|
Definition
1.Protein M (protein A in S. aureus) 2.Hyaluronic acid capsule 3.Streptokinase Enzymes 4.Hyaluronidase = spreading factor |
|
|
Term
Protein M ________ complement. Thereby interfering with opsonization, phagocytosis, and lysis of bacteria. |
|
Definition
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|
Term
Hyaluronic acid capsule acts to ______ the bacteria |
|
Definition
camouflage(WBC cannot recognize) |
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|
Term
Streptokinase Enzymes ______ blood clots and _______ spread of Streptococcus pyogenes into ______ and _____tissue |
|
Definition
dissolves, facilitates, damaged and infected |
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|
Term
Hyaluronidase called the ______ ______, dissolves hyaluronic acid and facilitates spread of Streptococcus pyogenes into deeper tissue |
|
Definition
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|
Term
What are Streptococcus pyogenes major Extracellular Toxins? 3 things |
|
Definition
Exotoxins Pyrogenic toxins/ Erythrogenic toxins Streptolysins toxins |
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|
Term
Streptococcus pyogenes :Pyrogenic toxins Stimulate______ and ______ cells to release cytokines/pyrogenes |
|
Definition
macrophages and helper T cells |
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|
Term
Streptococcus pyogenes :Pyrogenic toxins Stimulate ______ , causes ____ , and _____ toxic shock |
|
Definition
fever,rash and streptococcal |
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|
Term
Because Pyrogenic toxins cause blood capillaries near surface of skin to dilate producing a red rash known as ____ _____, Some scientist call the toxins _________ toxins |
|
Definition
(scarlet fever), Erythrogenic |
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|
Term
Streptolysins toxins Cause _____ of sheep blood agar. Clear zone around colony |
|
Definition
|
|
Term
Streptolysins toxins Lyses _____, _____ and _______Which interfere with O2 carrying capacity, Immunity, Blood clotting. |
|
Definition
RBCs, WBCs and Platelets. |
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|
Term
Streptolysins toxins also lyse other tissue cells such as |
|
Definition
Liver cells Cardiac muscle cells Kidney cells |
|
|
Term
Humans are only significant reservoir of ___ to ____ % of population are carriers of virulent strains of Streptococcus pyogenes |
|
Definition
|
|
Term
Streptococcus pyogenes Typically causes disease when: |
|
Definition
Competing normal flora is depleted Immunity is impaired When large inoculum enables it to get a foot hold (infectious dose) before antibodies form against it |
|
|
Term
Streptococcus pyogenes Causes following diseases: KNOW these 7 |
|
Definition
Strep throat Erysipelas Streptococcal toxic shock syndrome Necrotizing fasciitis Scarlet fever Rheumatic fever Post streptococcal glomerulonephritis |
|
|
Term
What is the Streptococcus pyogenes strain for Sore throat, strep throat, or tonsillitis ? |
|
Definition
Streptococcal pharyngitis |
|
|
Term
Bacteriological or serological testare needed for a sure diagnosis of ______ _____ |
|
Definition
Streptococcal pharyngitis |
|
|
Term
What is Streptococcal pharyngitis treated with? |
|
Definition
|
|
Term
|
Definition
a condition following and resulting from a disease |
|
|
Term
_____ is a morbid complication that follows a disease |
|
Definition
|
|
Term
Some diseases leave sequela In the form of long-term or permanent |
|
Definition
Damage to tissues or organs |
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|
Term
Examples of Sequelas: Meningitis can result in _____ |
|
Definition
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|
Term
Examples of Sequelas: Strep throat can result in _____ _____ |
|
Definition
|
|
Term
Examples of Sequelas: Strep throat can result in _____ ______ disease |
|
Definition
|
|
Term
|
Definition
|
|
Term
streptococcal impetigo is a localized _____ ______. |
|
Definition
|
|
Term
streptococcal impetigo Begins as small _____producing lesions that itch, break open and form contagious yellow crust on skin |
|
Definition
|
|
Term
Pyoderma = ____ producing lesion on skin of face, arms, and legs |
|
Definition
|
|
Term
Erisipelas =Slightly more invasive form of ______ infection spreads to _____ and _____ tissues. |
|
Definition
skin, dermis and subcutaneous |
|
|
Term
Streptococcus pyogenes: Erisipelas is called Erysipelas when this infection involved ____ _____. Triggers pain and inflammation |
|
Definition
|
|
Term
Hogs can get ______ and infected hogs can infect______ |
|
Definition
|
|
Term
Streptococcus pyogenes can also cause Streptococcal _____ _____ ______. |
|
Definition
|
|
Term
Patients are bacteremic with severe multi-system infections and failure if they contract ______? |
|
Definition
|
|
Term
|
Definition
|
|
Term
Necrotizing fasciitis Life threatening with mortality rate of ____% if left untreated |
|
Definition
|
|
Term
Flesh eating Streptococcus pyogenes follows the path of _____ between subcutaneous tissue and muscle and CT surrounding the muscles |
|
Definition
|
|
Term
Flesh eating Strep Streptococcus pyogenes first symptoms |
|
Definition
Swelling, heat, redness Skin changes from red to purple to blue to large blisters |
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|
Term
Flesh eating Streptococcus pyogenes Skin dies and muscle becomes infected. Need rapid therapy of which drug? |
|
Definition
|
|
Term
What are used to remove the dead tissue sometimes? |
|
Definition
|
|
Term
Rheumatic Fever is a sequila. which disease does it follow? What does it result in? |
|
Definition
strep throat Results in damage of heart valves and heart muscle. |
|
|
Term
Rheumatic Fever is an _______ response to Streptococcus pyogenes. |
|
Definition
|
|
Term
Rheumatic Fever is ______ mediated. Antigens in heart are similar to Antigens on Streptococcus pyogenes, and our_____attach to heart muscle, attack it and causes ____which can damage the heart valves. |
|
Definition
antibody, antibodies, myocarditis |
|
|
Term
Acute Glomerulonephritis = AGN Antibody-antigen complexes of ____ ____. Accumulate in ______. Obstructs blood flow through _____. |
|
Definition
Streptococcus pyogenes, glomeruli, kidneys |
|
|
Term
Acute Glomerulonephritis = AGN Sequela of ______ ______. |
|
Definition
|
|
Term
Acute Glomerulonephritis = AGN Leads to ______ and ______ urine output Face may be puffy, urine is _____ colored |
|
Definition
|
|
Term
Acute Glomerulonephritis = AGN may cause _____kidney damage in adults. |
|
Definition
|
|
Term
Diagnosis of Streptococcus pyogenes |
|
Definition
Observation of Gram-positive bacteria in short chains or pairs |
|
|
Term
Prevention of Streptococcus pyogenes: Antibodies against M protein provide long-term protection against future infection of S. pyogenes ONLY it it is _____? |
|
Definition
the same strain of Streptococcus (can get strep throat many times from different strains) |
|
|
Term
GBS = Group B Streptococcus: |
|
Definition
|
|
Term
Not until Lancefield classification scheme was Streptococcus agalactiae(GBS)Recognized in _____ |
|
Definition
|
|
Term
Streptococcus agalactiae Newborns with no antibodies are at risk of infection if born to previously uninfected mothers with no antibodies. Why is this? |
|
Definition
No antibodies for S. agalactiae were passed to fetus during late gestation |
|
|
Term
Streptococcus agalactiae normally colonizes which 3 things? |
|
Definition
GI, Genitals, and urinary tract |
|
|
Term
Newborns can pick up _____ ______ in birth canal during birth |
|
Definition
|
|
Term
CDC recommends prophylactic administration of ______ at birth to neonates whose mother’s urinary/genital tract is colonized with S. agalactiae |
|
Definition
|
|
Term
Streptococcus _____Causes serious infections in newborns and immunocompromised people |
|
Definition
|
|
Term
think Baby for GBS- Streptococcus _____ causes Causes of neonatal pneumonia, sepsis, and meningitis |
|
Definition
|
|
Term
Streptococcus agalactiae resides in human ____, ____, _____, and ______. |
|
Definition
pharynx, vagina, urinary tract, and large intestine. |
|
|
Term
Viridans Streptococci (verdant, viridis L. = green) |
|
Definition
Many produce green pigment when grown on blood agar |
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|
Term
Viridans Streptococci is the normal flora in ____, ____, _____, ____ and _____. |
|
Definition
Oral cavity, pharynx, GI tract, Urinary and genital tracts |
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|
Term
Ex. Of Viridans Streptococci Streptococcus mutans causes _____ _____. |
|
Definition
|
|
Term
During a dental procedures (routine cleaning teeth) there may be showers of Streptococcus mutans into the ______ |
|
Definition
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|
Term
Streptococcus mutans may cause |
|
Definition
|
|
Term
People with heart conditions or heart murmurs are given _____ antibiotics before visit to dentist. |
|
Definition
|
|
Term
Streptococcus pneumoniae Gram ____ cocci |
|
Definition
|
|
Term
Streptococcus pneumoniae most commonly forms pairs called ______, formally called _______ _______ |
|
Definition
diplococci Diplococcus pneumoniae |
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|
Term
There are ____ strains of Streptococcus pneumoniae discovered by ______. There are vaccines against ____ strains. |
|
Definition
|
|
Term
_____ % of all people carry Streptococcus pneumoniae as normal flora in mouth and pharynx without causing harm BUT if it moves to lungs causes |
|
Definition
|
|
Term
Steptococcus pneumoniae most common cause of which 3 things? |
|
Definition
Pneumonococcal pneumonia Sinusitis Otitis media |
|
|
Term
Streptococcus pneumoniae important cause of _______ ________ (since we now have a vaccine for Hemophilus influenzae, HiB vaccine), _____ and _____. |
|
Definition
Pneumococcal meningitis Bacteremia/sepsis Endocarditis |
|
|