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OCCTH 610 Physiology Intro Lecture
OCCTH 610 Physiology Intro Lecture
84
Health Care
Graduate
09/23/2010

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Term
What is a monosaccharide
Definition
-simple sugars with 3-7 carbon atoms
Term
What are disaccharides?
Definition
-2 simple sugars condensed by dehydration synthesis
Term
What are polysaccharides?
Definition
many monosaccharides condensed by dehydration synthesis
Term
What are 3 examples of monosaccharides?
Definition
glucose
galactose
fructose
Term
What are 3 examples of disaccharides?
Definition
sucrose
lactose
maltose
Term
What are 3 examples of polysaccharides?
Definition
cellulose
starch
glycogen
Term
What are the most abundant and important organic molecules?
Definition
proteins
Term
What are the important functional groups of organic molecules?
Definition
-COOH (Carboxylic Acid)
-NH2 (Amino Group)
-OH (Hydroxyl Group)
-PO4 (Phosphate group)
Term
What is an example of carboxylic acid
Definition
fatty acid
amino acids
Term
what is an example of an amine group
Definition
amino acids
Term
what is an example of a hydroxyl group?
Definition
carbohydrates
fatty acids
amino acids
Term
What is an example of a phosphate groups
Definition
phospholipids
nucleic acids
high energy compounds
Term
What are 3 examples of conjugated Carbohydrates
Definition
glycolipids
glycoproteins
proteoglycans
Term
What is hydrolysis
Definition
Hydrolysis is a chemical process in which a certain molecule is split into two parts by the addition of a molecule of water. One fragment of the parent molecule gains a hydrogen ion (H+) from the additional water molecule. The other group collects the remaining hydroxyl group (OH−).
Term
What is dehydration synthesis
Definition
a chemical reaction that involves the loss of water from the reacting molecule
Term
Name the three structural classes of carbs in the body
Definition
monosaccharides
disaccharides
polysaccharides
Term
Name 3 examples of carbs in the body
Definition
Glucose, fructose
sucrose, lactose, maltose
glycogen
Term
Lipids are mostly made of:
Definition
C, H, (1:2), & 0
Term
What are eicosanoids
Definition
signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system
Term
Eicosanoids are derived from:
Definition
fatty acid arachidonic acid
Term
What are two types of eicosanoids?
Definition
leukotrienes (active in immune system)
prostaglandins (local hormones, short-chain fatty acids)
Term
What are phospholipids?
Definition
class of lipids and are a major component of all cell membranes as they can form lipid bilayers. Most phospholipids contain a diglyceride, a phosphate group, and a simple organic molecule such as choline
Term
What is a lipid bilayer
Definition
a thin membrane made of two layers of lipid molecules. These membranes are flat sheets that form a continuous barrier around cells. The cell membrane of almost all living organisms and many viruses are made of a lipid bilayer, as are the membranes surrounding the cell nucleus and other sub-cellular structures. The lipid bilayer is the barrier that keeps ions, proteins and other molecules where they are needed and prevents them from diffusing into areas where they should not be. Lipid bilayers are ideally suited to this role because, even though they are only a few nanometers thick, they are impermeable to most water-soluble (hydrophilic) molecules. Bilayers are particularly impermeable to ions, which allows cells to regulate salt concentrations and pH by pumping ions across their membranes using proteins called ion pumps.
Term
What is a Glycolipid?
Definition
lipids with a carbohydrate attached. Their role is to provide energy and also serve as markers for cellular recognition.
Term
What is a steroid?
Definition
a type of organic compound that contains a specific arrangement of four rings that are joined to each other. Examples of steroids include cholesterol, the sex hormones estradiol and testosterone
Term
Name three examples of steroids?
Definition
cholesterol
estrogen
testosterone
Term
What are the two types of heads that a phospholipids contain
Definition
hydrophilic & hydrophobic
(Glycolipid = the hydrophilic part is the cholesterol)
Term
What are lipids?
Definition
a broad group of naturally occurring molecules which includes fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The main biological functions of lipids include energy storage, as structural components of cell membranes, and as important signaling molecules.
Term
Name 5 lipid types in the body:
Definition
Fatty Acids
Eicosanoids
glycerides
steroids
phospholipids/glycolipids
Term
What are the 7 functions of proteins
Definition
1. Structure (collagen, keratin)
2. Communication (some hormones, cell receptors)
3. Membrane transport (channels, carriers)
4. Catalysis (enzymes)
5. Recognition & Protection (antigens, antibodies & clotting proteins)
6. Movement (molecular motor = molecules that can change shape repeatedly)
7. Cell adhesion (proteins bind cells together)
Term
What are the 4 basic elements that proteins contain?
Definition
C (Carbon)
H (Hydrogen)
O (Oxygen)
N (Nitrogen)
Term
What are the 3 main parts of an amino acid struture
Definition
Amino group
R Group
Carboxylic Acid Group
Term
What is a protein?
Definition
organic compounds made of amino acids arranged in a linear chain and folded into a globular form. The amino acids in a polymer are joined together by the peptide bonds between the carboxyl and amino groups of adjacent amino acid residues.
Term
What are the 4 different protein structures?
Definition
Primary structure
Secondary structure
Tertiary structure
Quaternary Structure
Term
What are the two main types of proteins:
Definition
FIBROUS PROTEINS
(structural sheets or strands)

GLOBULAR PROTEINS
(soluble spheres with active functions)
(protein function is based on shape)

**Shape is based on sequence of amino acids**
Term
What are Enzymes?
Definition
CATALYSTS
* proteins that lower the activation energy of a chemical reaction
SPECIFIC
LIMITED
REGULATED
Term
What are the 3 steps in an Enzyme reaction?
Definition
1. substrates bind to active site of enzyme
2. aided by enzyme, substrates interact to form product
3. product detaches from enzyme; entire process can no be repeated
Term
What is a cofactor?
Definition
a non-protein chemical compound that is bound to a protein and is required for the protein's biological activity. These proteins are commonly enzymes, and cofactors can be considered "helper molecules" that assist in biochemical transformations. Cofactors can also be classified depending on how tightly they bind to an enzyme, with loosely-bound cofactors termed coenzymes
Term
What are Coenzymes
Definition
Nonprotein organic Cofactors (Vitamins)
Term
What is a cofactor?
Definition
An ion or molecule that binds to an enzyme before substrates can bind
Term
What are isozymes?
Definition
are enzymes that differ in amino acid sequence but catalyze the same chemical reaction
* two enzymes that can catalyze the same reaction
Term
What are Nucleic Acids
Definition
Large organic molecules that STORE & PROCESS INFORMATION at the molecular level
Term
What are two examples of Nucleic Acids
Definition
DNA (Deoxyribonucleic Acid)
RNA (Ribonucleic Acid)
Term
What does DNA do?
Definition
1.Determines inherited characteristics
2. Directs protein synthesis
3. Controls enzyme production
4. Controls metabolism
Term
What does RNA do?
Definition
controls intermediate steps in protein synthesis
Term
What is protein synthesis
Definition
the process in which cells build proteins. The term is sometimes used to refer only to protein translation but more often it refers to a multi-step process, beginning with amino acid synthesis and transcription of nuclear DNA into messenger RNA, which is then used as input to translation.
Term
What are the 3 components of a Nucleotide
Definition
Sugar
Phosphate
(Nitrogenous Base)

In RNA the Sugar is Ribose
Term
What are the two types of nitrogenous bases within a nucleotide?
Definition
Purines
pyrimidines
Term
Name two specific purines?
Definition
adenine (RED)
guanine (GREEN)
Term
What are the 3 specific pyrimidines
Definition
cytosine (PURPLE)
thymine (BLUE) (DNA ONLY)
Uracil (GREY) (RNA ONLY)
Term
Name 3 types of RNA
Definition
mRNA (Messenger RNA)
tRNA (Transfer RNA)
rRNA (Ribosomal RNA)
Term
Adenine binds to ?
Definition
Thymine
Term
Guanine binds to?
Definition
cytosine
Term
What is ATP?
Definition
Adenosine-5'-triphosphate (ATP) is a multifunctional nucleotide used in cells as a coenzyme. It is often called the "molecular unit of currency" of intracellular energy transfer.[1] ATP transports chemical energy within cells for metabolism. It is produced by photophosphorylation and cellular respiration and used by enzymes and structural proteins in many cellular processes
Term
How many phosphates does ATP contain
Definition
3
Term
Process of Making Energy
Definition
ATP Binds with ATPase (hydrolysis)
This creates ADP (ENERGY) (ADP + Pi)
Term
What are nutrients?
Definition
essential molecules obtained from food
Term
What are metabolites
Definition
molecules made or broken down in the body
Term
What are inorganic Molecules
Definition
molecules not based on Carbon & hydrogen
Term
What are examples of inorganic molecules?
Definition
carbon dioxide
oxygen
water
inorganic acids, bases, salts
Term
What are organic molecules
Definition
molecules based on carbon and hydrogen
Term
What are examples of organic molecules?
Definition
carbohydrates
proteins
lipids
nucleic acids
Term
What are the 5 major elements in the human body
Definition
Oxygen
carbon
hydrogen
nitrogen
calcium
phosphorus
Term
What are the 4 major important parts of Water
Definition
1. solubility
2. reactivity
3. high heat capacity
4. lubrication
Term
What is solubility?
Definition
waters ability to dissolve a solute in a solvent to make a solution
Term
What is reactivity?
Definition
most body chemistry occurs in water
Term
What is high-heat capacity?
Definition
waters ability to absorb and retain heat
Term
What is the importance of lubrication?
Definition
to moisten and reduce friction
Term
On the pH scale what is considered Neutral?
Definition
7
Pure water
Term
On the pH scale what is considered extremely acidic
Definition
0 zero
hydrochloric acid
Term
On the pH scale what is considered extremely basic
Definition
14
sodium hydroxide
Term
What are a few examples of things that are acidic in order from greatest to least ?
Definition
hydrochloric acid
stomach acid
beer, vinegar, wine, pickles,
tomatoes, grapes
saliva, milk
Term
What are examples of things that are basic from greatest to least
Definition
sodium hydroxide
oven cleaner
household ammonia
household bleach
ocean water
eggs
blood
Term
What is an acid
Definition
1. a solute that adds hydrogen ions to a solution
2. proton donor
3. strong acids dissociate completely in solution
Term
What is a Base?
Definition
1. A solute that removes hydrogen ions from a solution
2. Proton acceptor
3. strong bases dissociated completely in solution
Term
What are two components of weak acids and weak bases?
Definition
1. fail to dissociate completely
2. help to balance the pH
Term
What are Salts?
Definition
solutes that dissociate into cations & anions other then hydrogen ions & hydroxide ions.
Term
What is a buffer?
Definition
1. weak acid/salt compounds
2. neutralizes either strong acid or strong base
3. sodium bicarbonate is very important in humans
Term
What is an antacid?
Definition
1. A basic compound that neutralizes acid and forms a salt
2. Tums, Rolaids, etc.
Term
What is pH?
Definition
s a measure of the acidity or basicity of a solution
Term
What is alkalinity?
Definition
a measure of the ability of a solution to neutralize acids to the equivalence point of carbonate or bicarbonate
Term
What are carbs made up of?
What are lipids made up of?
Definition
C, H, O (1:2:1)
C, H (1:2) O
Term
What is most likely to be changed by heating a protein, its primary structure or its tertiary structure
Definition
A protein’s tertiary structure is much more likely to be altered in heating because the bonds holding a tertiary structure together are hydrogen bonds, which are relatively weak, while the peptide bonds holding together the primary polypeptide are covalent bonds, which are much stronger.
Term
Which reaction - dehydration synthesis or hydrolysis converts a polymer to its monomers?

Monomers to polymer
Definition
dehydration synthesis = is a type of condensation reaction in which monomers join together into polymers while losing water molecules. This process is carried out by losing (-OH) from one of the monomers and (H) from anothermonomer. The two unstable monomers join together, and the (-OH) and (H) combine forming water (H2O).

hydrolysis:Polymers convert into monomers. It is a chemical process in which a molecule is split into 2 parts by the addition of a molecule of water. One fragment of the parent molecule gains a hydrogen ion (H + ) from the additional water molecule. The other group collects the remaining hydroxyl group (OH − )
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