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Oc Dz midterm 2
review
112
Biology
Graduate
03/07/2012

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Term
What is lentigo maligna commonly called?
Definition
Hutchinson's freckle
Term
What does 'in situ' mean?
Definition
localized to it's original area
Term
What is the minimum and mean age for lentigo maligna?
Definition
above 40; mean of 65
Term
What is a risk factor for lentigo maligna?
Definition
Fair skin
Term
Where is lentigo maligna commonly seen?
Definition
head and neck
Term
What is the malignancy risk for lentigo maligna?
Definition
15.00000%
Term
What does serpiginous mean?
Definition
Serpent-like
Term
What can have serpiginous borders?
Definition
lentigo maligna
Term
What is the tx for lentigo maligna?
Definition
refer for biopsy/surgery
Term
What are acrochordon?
Definition
skin tags, soft warts
Term
What is the incidence of acrochordon?
Definition
46.00000%
Term
What causes acrochordons?
Definition
localized elastic tissue
Term
What does pedunculated mean?
Definition
It is shaped like a stalk
Term
What type of tissue growth is acrochordon?
Definition
neoplasm
Term
What is a common comorbity for acrochordon?
Definition
obesity
Term
How do you treat acrochordon?
Definition
snip it, freeze it, zap it or apply meds
Term
What medicine treats acrochordon?
Definition
chromium picolinate 200 mcg BID
Term
What is a papilloma?
Definition
benign epithelial tumor
Term
What is the cause of papillomas?
Definition
epithelial overgrowth
Term
What shape are papillomas?
Definition
lobulated
Term
What is the treatment for papilloma?
Definition
Dermatologist consult, removal RTC q. 3-6 mo; RTC q. 1yr.
Term
What does sessile mean?
Definition
flattened
Term
What are the two shapes that papillomae can take onm?
Definition
flattened or pedunculated
Term
What commonly looks like cauliflower?
Definition
papilloma
Term
Can papilloma be pigmened or non-pigmented?
Definition
Both
Term
What is seborrheic keratosis?
Definition
basal cell nyperplasia
Term
"barnacles of old age"
Definition
seborrheic keratosis
Term
What kind of plaque are seborrheic keratosis?
Definition
hyperkeratinized
Term
What are the most common benign epidermal tumors in the elderly?
Definition
seborrheic keratosis
Term
How elevated are seborrheic keratosis spots?
Definition
1-6mm
Term
What kind of lesions are waxy, greasy, or scaly
Definition
seborrheic keratosis
Term
What is the tx for seborrheic keratosis
Definition
Derm. Consultation; cyro, excision, curettage; RTC g. 6-12 mo
Term
What is lichen planus?
Definition
A common pruitic eruption
Term
What is the typical age of onset for lichen planus?
Definition
30-60 yo
Term
What is the prevalence of lichen planus in dermatology clinics?
Definition
1% of all new pts
Term
What disease present flat topped violacous papules?
Definition
lichen planus
Term
What is the typical size of lichen planus papules?
Definition
2-4 mm
Term
What is the cause of lichen planus?
Definition
cell mediated immune response of unknown origin
Term
What is the four pronged management plan for lichen planus?
Definition
biopsy, steroids, vit A, retinoids
Term
What are verrucae?
Definition
viral warts
Term
What is a common viral cause of verrucae?
Definition
HPV
Term
What are verruca plantaris?
Definition
wart on the sole or toes of foot
Term
Are verrucae benign or malignant?
Definition
benign
Term
What are the three shapes of verrucae?
Definition
1. verruca plana 2. verruca vulgaris 3. verruca digitata
Term
What grows faster, papilloma or verrucae?
Definition
Verrucae
Term
Are verrucae contagious?
Definition
yes, on skin contact
Term
What is molluscum contagiosum?
Definition
benign skin tumor
Term
What is the cause of molluscum contagiosum?
Definition
virus (pox); associated with HIV
Term
Are molluscum contagiosum contagious?
Definition
yes; skin on skin or swimming pools
Term
What does umbilicated mean?
Definition
small divot
Term
What are commonly described as umbilicated?
Definition
molluscum contagiosum
Term
What is the description of molluscum contagiosum?
Definition
elevated, round, waxy, pearly
Term
What is the tx for molluscum contagiosum?
Definition
excision, cryo, topical salicylic acid
Term
Can molluscum contagiosum have central discharge?
Definition
yes
Term
What are the two main herpes eye infections?
Definition
zoster and simplex
Term
What is poliosis?
Definition
Auto immune attack of eyelash melanocytes --> white lashes
Term
What causes poliosis?
Definition
staph bleph; albinism; Vog-Koyanagi-Harada syndrome
Term
What does VKH stand for?
Definition
Vogt-Koyanagi-Harada syndrom
Term
Poliosis tx?
Definition
treat the bleph; refer if albinism/VKH present
Term
What is vitiligo?
Definition
hypopigmentation of skin
Term
What are s/sx of vitiligo?
Definition
usually bilateral eyelid presentation, frequently positive FHx
Term
What age does vitiligo present?
Definition
Usually before 20
Term
What is the cause of vitiligo?
Definition
idiopathic
Term
Is vitiligo progressive?
Definition
yes
Term
What is the occurrence of vitilgo?
Definition
1-2% worldwide, more often in dark skinned people
Term
Vitiligo tx?
Definition
determine of FHx;

rule out associated syndromes,

use cosmetic camouflage,

sunscreen,

melanocyte stimulation and skin color blending w/ amino acids
Term
What is the long term tx for vitiligo?
Definition
steroids
Term
What must be done with vitiligo pts?
Definition
Referred to dermatologist
Term
What is Vogt Koyanagi Harada Syndrome?
Definition
rare, multisystem disorder.

Common age 20-50
Term
What is VKH phase 1?
Definition
Prodromal phase

Lasts a few days with meningitis, encephalopathy, auditory disturbances
Term
What is VKH phase 2?
Definition
Acute uveitic phase: anterior and posterior uveitis
Term
What is VKH phase 3?
Definition
Convalescent phase; first three of the sx below most common

Alopecia, poliosis, vitiligo, fundus lesions, depigmented limbal lesions
Term
What is VKH phase 4?
Definition
Chronic-Recurrent phase

smoldering anterior uveitis w/ exacerbations
Term
Three of what four signs must be present to diagnose VKH?
Definition
bilateral chronic anterior uveitis

posterior uveitis

cutaneous lesions

neurological features
Term
What is a severe hallmark sign of VKH?
Definition
acute serous retinal detachment
Term
Where is sunset glow fundus found?
Definition
Convalesent phase of VKH
Term
What is the tx plan for VKH?
Definition
oral steroids

periocular injected steroids

topical steriods for anterior uveitis

If steroids are not sufficient, use immunosuppressive agents cyclosporine or chlorambucil
Term
What does OCP stand for?
Definition
Ocular Cicatricial Pemphigoid
Term
What is OCP?
Definition
systemic autoimmune inflammatory disease

mucous membrane disorder involving the conjunctiva, often asymmetric
Term
What type of hypersensitivity is OCP?
Definition
Type 2 hypersensitivity
Term
What is the prevalence of OCP?
Definition
Rare

1/8k to 1/45k
Term
What is a pemphigoid?
Definition
blister or swelling
Term
What is a significant side effect of OCP?
Definition
bilaterally blindness/visual loss
Term
Why does OCP scar?
Definition
Blisters form, swell, and burst repeatedly until scars are formed
Term
What blisters in OCP?
Definition
skin and mucous membranes
Term
What can be asymmetric in OCP?
Definition
time of onset

severity

rate of progression
Term
When is conjunctival dx seen in OCP?
Definition
75% w/oral involvement; 25% w/ skin lesions
Term
Name some characteristics of OCP
Definition
idiopathic

chronic

progressive

female > male
Term
What is the age of onset for OCP?
Definition
6th or 7th decade, often subtle and hard to detect, though early detection crucial for preventing vision loss
Term
What is stage1 of OCP?
Definition
Conjunctivitis
Term
What is stage 2 of OCP?
Definition
Conjunctival scarring and shrinkage

worsens over 3-4 years

continued scarring and shrinkage
Term
What is stage 3 of OCP?
Definition
symblepharon formation
Term
What is stage 4 of OCP?
Definition
end stage with corneal scarring and anklyblepharon
Term
What is a symblepharon?
Definition
fibrous tissue adhering bulbar to palpebral conj
Term
What is anklyoblepharon?
Definition
Severe overgrowth of tissue over the cornea?
Term
What is the endstage of OCP?
Definition
scarred, opaque cornea
Term
What are other DDx related to OCP?
Definition
Chemical trauma

radiation injury

other mucous membrane disorders
Term
What % of OCP cases are confirmed with a conjunctival biopsy?
Definition
83.00000%
Term
How can OCP cause dry eye?
Definition
destroys goblet cells and meibomian glands
Term
What is Dapsone used for?
Definition
Treating the acute inflammatory stage of OCP
Term
What are ocular therapies for OCP?
Definition
treat w/ surgery:

trichiasis, entropion and symblepharon
Term
What is Stevens-Johnson Syndrome?
Definition
acute but self limiting (non-progressive) inflammation with minor and major variants
Term
What is EM minor?
Definition
skin and maybe a single mucosal membrane affected
Term
What is EM major?
Definition
Involves skin and two or more mucosal membranes
Term
How long can EM last?
Definition
1-4 weeks
Term
What is usually seen with SJS?
Definition
Systemic toxicity causing malaise, fever, sore throat, HA
Term
What is the mortality rate of SJS?
Definition
1-5%
Term
How long can SJS last?
Definition
6 weeks
Term
What % of SJS is seen in children?
Definition
20.00000%
Term
Who are more likely to get SJS?
Definition
men, though no racial predilection
Term
What is the etiology of SJS?
Definition
Thought to be delayred hypersensitivity response to drugs and epithelial cell antigens
Term
What is common pharmacological cause of SJS reaction?
Definition
sulfonamides***

penicillin, nsaids, etc
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