Term
| T/F: a combination of central and peripheral signals (ghrelin and cortisol) initiate feeding |
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Definition
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Term
| T/F: Leptin provides a signal of adiposity. Most obese individuals are NOT leptin deficient…so giving leptin to patients does not provide really that big of an effect |
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Definition
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Term
| What'st he most common single gene defect? |
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Definition
MC4-Receptor
Most common defect
Up to 10 known single defects leading to human obesity. These with syndromic obesity added explain about 10% of obesity seen today. Rest is polygeneic and multifactorial. |
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Term
| Most common cancers a/w obesity: |
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Definition
breast, uterus, cervix
colon, esophagus, pancreas
kidney, prostate |
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Term
| Drugs approved by FDA for treating obesity longterm |
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Definition
only sibutramine (Meridia) and orlistat (Xenical) have been approved for long-term use
All the approved medications act as anorexiants, with the exception of orlistat, which blocks the absorption of dietary fat. Anorexiants increase satiation (level of fullness, which regulates the amount of food consumed during a meal) or satiety (level of fullness after a meal, which determines frequency of eating), or both.
(Diethylproprion, phentermine, phendimetrazine, benzphetamine) |
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Term
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Definition
| Orlistat prevents fat digestion and absorption by binding to gastrointestinal lipases |
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Term
| Bupropion+ Zonisamide for Weight Loss outcomes? |
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Definition
24 weeks Results:
Zonisamide alone about 4 to 5% weight loss vs. Combination: about 6% weight loss
Side effects: Insomnia, nausea, fatigue and headache seen up to 10% |
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Term
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Definition
37–amino acid -cell hormone co-secreted with insulin in response to meals
Acts as a neuroendocrine hormone
Binds to specific receptors in the hindbrain, including the area postrema
Increases proopiomelanocortin expression in the arcuate nucleus (ARC) |
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Term
| T/F: bariatric surgeries are a good anti-obesity national policy |
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Definition
F: only
BMI > 40 or BMI > 35 with at least 2 weight-related comorbidities
Documented previous failed attempts at non-surgical weight loss
Stable, cooperative, able to tolerate surgery, informed
Gastric bypass better weightloss and have more fx on insulin VS>. adjustable gastric band lap band |
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Term
| QUIZ: #1 predictor is self-monitored weight loss and activity QUIZ! |
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Definition
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