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OB pharmacology
OB Pharmacology
41
Pharmacology
Undergraduate 3
08/29/2011

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Term
uterine stimulants
Definition
oxytocin, ergot alkoloids, prostoglandins
Term
prenate elite
Definition
high in folic acid, iron, and calcium
Term
prenate interactions
Definition
aspirin, fluoroquinolone antibiotics, tetracycline antibiotics, bisphosphonates, and thyroid medications
Term
oxytocin
Definition
natural uterine stimulant
Term
pitocin
Definition
synthetic oxytocin, uterine stimulant
Term
methergine (methylergonovine maleate)
Definition
semi-synthetic ergot alkaloid given after delivery of placenta
Term
methergine
Definition
comes from grain fungus related to lysergic acid
Term
pitocin is used to ...
Definition
induce and sustain labor
Term
oxytocin can...
Definition
be released when the nipples are stimulated
Term
prepidil, cervidil
Definition
is a gel applied vaginally to ripen the cervix
Term
cytotec (misoprostol)
Definition
used to prevent ulcers, used to ripen the cervix, do not use if breastfeeding
Term
uterine relaxants
Definition
magnesium sulfate, ritodrine HCl, terbutaline sulfate (brethine)
Term
magnesium sulfate
Definition
is metabolized by the kidneys
Term
MgSO4
Definition
magnesium sulfate
Term
mag sulfate needs to be
Definition
monitored very closely, if excessive amounts of MgSO4 the drug can cause profound muscle weakness and respiratory arrest
Term
myasthenia gravis
Definition
dont use MgSO4 because the disease causes muscle weakness
Term
renal failure
Definition
because magnesium is eliminated entirely by the kidneys
Term
hypocalcemia
Definition
muscle weakness
Term
magnesium sulfate can cause ___________in newborns
Definition
sleepiness and muscle weakness requiring a ventilator
Term
terbutaline sulfate (USO)
Definition
used to delay preterm labor by inhibiting uterine contractions
Term
terbutaline sulfate is administered
Definition
given IV or SQ for up to 48 hrs SQ pump required
Term
terbutaline sulfate maternal side effects
Definition
pulmonary edema, tachycardia, palpitations, chest pain, myocardial ischemia, hypotension, hyperglycemia
Term
terbutaline sulfate fetal side effects
Definition
fetal tachycardia, hypotension, ileus, hyperinsulinemia with hypoglycemia, hyperbilirubinemia, hypocalcemia, jaundice
Term
lactation suppressants
Definition
bromocriptine mesylate (parlodel),
Term
estrogen is no longer used for
Definition
lactation suppressant
Term
abortion inducers
Definition
intra-amniotic injection of hypertonic (20%) NaCL
Term
intra-amniotic injection of hypertonic 20% NaCL is given
Definition
during the second trimester, a needle is inserted into the mother's abdonmen 50-250ml of amniotic fluid is replaced with 20% NaCL
Term
hypertonic saline may initiate a condition in the mother
Definition
called consumption coagulatiopathy-uncontrolled blood clotting throughout the body with severe hemorrhage
Term
hypertonic 20% NaCL
Definition
the fetus swallows the salt and is poisoned, after about an hour the fetus dies. mother delivers her dead fetus 72 hours later
Term
mifepristone and misoprostol
Definition
abortion inducer given during 2nd trimester
Term
day 1 mifepristone 600mg given, if abortion has not occured day 3...
Definition
misoprostol 400mcg orally, day 14 ultrasound given to determine completed abortion
Term
prostin E2
Definition
abortion inducer given 2nd trimester
Term
prostin E2 given...
Definition
vaginal suppository, this stimulates the myometrium to contract
Term
prostin E2 may
Definition
not kill the baby entirely when it is aborted
Term
prostin E2 can be given
Definition
12th through the 20th gestation week
Term
prostin E2 can cause
Definition
high fever and the aborted fetus is delivered vaginally
Term
prostin E2 must be stored
Definition
in a freezer not above -20c(-4f)
Term
RhoGAM
Definition
is given when incompatability between mothers blood RH+ and her RH- fetus
Term
RhoGAM must be given
Definition
within 72 hours following delivery or abortion to protect future pregnancies
Term
alloimmunization
Definition
A condition in which red blood cells of the fetus become coated with immunoglobulin G antibody (Rh antibody) of maternal origin which is directed against Rh-D antigen of paternal origin that is present on fetal cells
Term
RhoGAM
Definition
can cause anemia and an increase in unconjugated bilirubin
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