Term
What is the transformation of bilaminar disk to trilaminar disc? |
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Definition
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Term
when does gastrulation occur? |
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Definition
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Term
Where is the ectoderm, mesoderm, and endoderm derived? |
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Definition
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Term
where is urogenital ridge derived from |
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Definition
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Term
when is the embryonic period? |
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Definition
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Term
Genetic sex is determined... |
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Definition
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Term
gonadal sex is determined.... |
|
Definition
8-11 weeks; determined by influence of the genetic sex on undifferentiated gonad |
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Term
ducal sex is determined... |
|
Definition
9-12 weeks; determined by the presence or absence of testicular products |
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Term
genital sex is determined... |
|
Definition
12-20 weeks determined by presence or absence of androgen |
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Term
where do germ cells originate? |
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Definition
in the primary ectoderm of the embryo and migrate into the yolk sac |
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Term
when does the urogenital ridge form? |
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Definition
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Term
The y-chromosome consists of two very important regions that determine "maleness," which is... |
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Definition
SRY and TDF (sex determining region of y chromosome, and testis-determining factor) |
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Term
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Definition
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Term
what is the key product of sertoli cells of a male during fetal development? |
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Definition
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Term
What is the function of Leydig cells in the male during embryo-genesis? |
|
Definition
produce testosterone for differentiation of external genitalia and formation of wolffian ducts |
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Term
What type of anomalies in the fetus account for highest of all body systems? |
|
Definition
urogenital tract anomalies (10%) |
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Term
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Definition
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Term
Is urinary/breat history part of gynecological history? |
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Definition
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Term
GaPbcde what do the subscripts stand for? |
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Definition
a=how many times they've been pregnant b=to full term (at least 37 weeks) c=to pre-term (20 weeks) d=miscarriages/abortions e=living children |
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Term
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Definition
A woman with 2 kids who has had one pre-term delivery, no misscarriages, and is currently pregnant |
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Term
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Definition
Glands on the vagina that is disto-lateral to the vaginal opening |
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Term
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Definition
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Term
pouch of douglas is also known as |
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Definition
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Term
is the isthmus of the uterine tube fixed or flexible? |
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Definition
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Term
The right ovary is drained to the.... |
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Definition
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Term
the left ovary is drained by the |
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Definition
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Term
when is there a heartbeat? when can it be seen on ultrasound? on doppler? |
|
Definition
3-4 weeks; 6-7 weeks; 12 weeks |
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Term
when is fetal movement first detected? |
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Definition
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Term
What time period is the most important for major defects of the fetus? |
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Definition
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Term
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Definition
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Term
Does estrogen increase or decrease the risk of clots? |
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Definition
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|
Term
By what percentage does blood volume increase during pregnancy? |
|
Definition
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|
Term
Pelvic inflammatory disease is defined as.... |
|
Definition
generic term for inflammation of uterus, fallopian tubes, and/or ovaries |
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|
Term
What is the concern with pelvic inflammatory disease and pregnancy? |
|
Definition
Increased risk of tubal pregnancies |
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Term
What does TORCH stand for |
|
Definition
toxoplasmosis other (parvo, EBV, Varicella, Syphilis) rubella CMV hepatitis (B and C) and herpes |
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Term
How many extra calories must a mother eat per day during pregnancy? |
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Definition
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|
Term
Baby movement is not consistent until... |
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Definition
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|
Term
When is the uterus first measure in pregnant mom? |
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Definition
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Term
When is Rho-gam administered? |
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Definition
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|
Term
When is GBS swab performed? |
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Definition
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|
Term
When do doctors screen of TORCH? |
|
Definition
Don't screen during pregnancy because nothing they can do about it, but be done postnatally only |
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Term
Toxoplasmosis has an increased risk of infection during which trimester? |
|
Definition
the 3rd; although first trimester infection to fetus is more severe |
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|
Term
What is fetal toxoplasmosis infection associated with? |
|
Definition
abortion, prematurity, growth retardation |
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|
Term
What are the symptoms of a mother with toxoplasmosis infection? |
|
Definition
Mother only has mild, vague symptoms so prevention is the best method to prevent infection (i.e. don't clean litter box, keep indoor cats inside) |
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|
Term
What is the prognosis for an infant infected with CMV? |
|
Definition
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|
Term
What are some of the symptoms associated with a fetus infected with CMV? |
|
Definition
prematurity, lbw, microcephaly, chorioretinitis, thrombotic thrombocytopenic purpura...BLUEBERRY BABY |
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Term
|
Definition
hematopoetic centers of body (spleen, bone marrow) and forms ectopic hematopoetic sites |
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Term
A mother with a heterophile negative mononucleosis syndrome has... |
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Definition
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Term
|
Definition
1 is mostly upper body (mouth) and 2 is lower body (2) although not set in stone anymore |
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Term
What preventative measures are given to a mother with herpes infection? |
|
Definition
acyclovir @ 36 weeks regardless of active lesions or not |
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|
Term
If there are active lesions of herpes on mother during delivery what must be done? |
|
Definition
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|
Term
What are the symptoms of a baby infected with herpes during delivery? |
|
Definition
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|
Term
rubella is also known as... |
|
Definition
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|
Term
what are some of the symptoms of a fetus infected with rubella virus? |
|
Definition
cataracts, deafness, patent ductus arteriosis |
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Term
The attack rate of this microbe is low but always results in death of fetus. |
|
Definition
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|
Term
What is the treatment for GBS |
|
Definition
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|
Term
When is the worst time during pregnancy to be infected by parvovirus B-19 |
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Definition
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|
Term
During what season is parvovirus most prevalent? |
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Definition
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|
Term
Parvovirus has a predilection towards what cells in fetus? |
|
Definition
erythroid progenitor cells |
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|
Term
What does parvovirus cause in fetus? |
|
Definition
fetal hydrops (conjestive heart failure) secondary to aplastic anemia |
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|
Term
What is defined as a UTI? |
|
Definition
greater than 100,000 pure colonies/cc of urine |
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|
Term
What are some of the common microbes that cause UTIs |
|
Definition
E. Coli, proteus mirabilis, GBS, klebsiella pneumoniae Proteus mirabilis and GBS have no nitrate-->nitrite |
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|
Term
Is gonorrhea intracellular or extracellular? Gram-negative or positive? |
|
Definition
Intracellular, gram -, diplococci |
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|
Term
What is given to infant at birth to prevent blindness? |
|
Definition
silver nitrate (for chlamydia and gonorrhea) |
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|
Term
What is the microbe that causes syphilis? |
|
Definition
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|
Term
What test can be done to see if mother is infected with syphilis? |
|
Definition
fluorescent treponemal antibody screen |
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|
Term
What is the Jarisch-Herxheimer reaction? |
|
Definition
Occurs after treatment of syphilis (penicillin)...begins 2-8 hours post therapy, gets chills fever because of release of endotoxin |
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Term
What are some of the symptoms of syphilis infection in utero? |
|
Definition
hydrops, large placenta, hepatosplenomegaly |
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|
Term
Infant syphilis infection presentation |
|
Definition
persistant rhinitis, generalized lymphadenopathy, osteochondritis (radiographs reveal alternating densities) |
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|
Term
Presentation of child with syphilis |
|
Definition
hitchinson's teeth, intersititial keratitis, 8th nerve damage (hearing) |
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|
Term
Trichomonas is present in what vaginal pH |
|
Definition
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|
Term
What is the plan for HIV infected mother during pregnancy? |
|
Definition
Initiate Azt after 1st trimester, do C-section, azt to infant after birth, and no breast feeding |
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Term
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Definition
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|
Term
Because there is a windo between HBsAg dissapearance and HBsAG appearance, ___ is used |
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Definition
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|
Term
What is the percent loss after implantation? |
|
Definition
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|
Term
What is the percent loss of fertilized oocytes before implantation? |
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Definition
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|
Term
In each ovulatory cycle, only ____ percent can of normally fertile couples can achive a live birth |
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Definition
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|
Term
pill has ___percent failure (inluding human error) |
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Definition
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|
Term
What does estrogen in the pill do? |
|
Definition
stabilizes endometrium (reduces menstrual bleeding) |
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|
Term
What is the definition of pregnancy according to WHO? |
|
Definition
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|
Term
What is provera? what are some of the complications? |
|
Definition
injected progesterone, exacerbate depression, appetite |
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|
Term
Copper t380 IUD vs. Mirena IUD |
|
Definition
1. sterile inflammation, good for 10 years, sperm cannot survive, increased blood loss 2. Progesterone releasing, decreased blood loss, increased risk of ectopic pregnancy |
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Term
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Definition
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|
Term
Condoms have a ____ percent failure rate |
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Definition
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|
Term
Doing nothing has a ____ percent failure rate |
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Definition
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|
Term
What is the leading cause of pregnancy-related deaths (of mother) during the first trimester? |
|
Definition
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|
Term
What accounts for the increasingly high rate of ectopic pregnancies? |
|
Definition
promiscuity, pelvic inflammatory disease, IUDs, tubal surgeries |
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|
Term
What is the worst place to have an ectopic pregnancy? The best? |
|
Definition
corneal (where uterine tube and uterus meets) fimbrial |
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|
Term
If a woman has abdominal pain, always always always do this... |
|
Definition
pregnancy test (abdominal pain is the only sure symptom of ectopic pregnancy, other symptoms will vary) |
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|
Term
can you still have a period with ectopic pregnancies? |
|
Definition
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|
Term
What is one of the major problems after delivery of an ectopic fetus? |
|
Definition
bleeding (no contraction of uterus to prevent!) |
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|
Term
Of all ectopic pregnancies, ampullary accounts for _____% |
|
Definition
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|
Term
Are progesterone levels usually high or low in ectopic pregnancies? |
|
Definition
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|
Term
What hCG levels are necessary to view ectopic pregnancies with abdominal u/s? vaginal u/s? |
|
Definition
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|
Term
|
Definition
extraction of recto-uterine pouch fluid. |
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|
Term
A Culdocentesis reveals non-clotting blood. What is this indicative of? |
|
Definition
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|
Term
what is a treatment option for ectopic pregnancy? |
|
Definition
methotrexate (need reliable patient) this is an abortifacient |
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|
Term
what is the definition of abortion? |
|
Definition
delivery of fetus weighing less than or equal to 500 grams or less than 20 weeks gestation |
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|
Term
what is a habitual abortion |
|
Definition
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|
Term
what is a missed abortion |
|
Definition
fetus died, but no bleeding |
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|
Term
what percentage of pregnancies will result in miscarriage in 1st trimester? |
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Definition
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|
Term
what are the 4 most common uterine abnormalities that accounts for miscarriage? |
|
Definition
1. mullerian fusion abnormalities 2. synechiae (intrauterine adhesions) 3. leiomyoma (fibroid, muscle growth) 4. incompetent cervical os (2nd trimester loss) |
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Term
|
Definition
stitching to fix an incompetent uterus |
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|
Term
What is a luteal phase defect? |
|
Definition
insufficient progesterone support of implantation site trophoblasts should take over the corpus luteum at apporximately 7 weeks gestation |
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Term
What are some of the methods of abortion/ |
|
Definition
dilation and curttage pitocin prostaglandin (contractions) laminaria (sea-weed stick, expands, cervix dilates and contractions start) dilation and evacuation |
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|
Term
Is DIC a potential complication after an abortion? |
|
Definition
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|
Term
How common is infertility? |
|
Definition
Affects 10-15% of couples |
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|
Term
|
Definition
normal vaginal opening, but anxiety can clamp vagina together completely |
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|
Term
Factors for infertility, (give percentages): male factor ovulation factors uterine/cervical factors medical factors unexplained |
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Definition
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|
Term
At what blood pressure should worsening HBP be given medication? |
|
Definition
160/100 (DO NOT GIVE ACE INHIBITORS) |
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|
Term
When is pre-eclampsia most common? |
|
Definition
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|
Term
Morbidity/mortality of fetus/mom with eclamptic mother |
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Definition
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|
Term
C/s or vaginal delivery with eclampsia? |
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Definition
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|
Term
what is the antidote of magnesium sulfate |
|
Definition
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|
Term
what is the most common cause of 3rd trimester bleeding? |
|
Definition
rupture of membranes (but rule out placental previa, vasa previa, placental abruption |
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Term
What must be done with placenta previa? |
|
Definition
must have C/S because baby cannot come out before placenta |
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Term
|
Definition
help to open cervix for labor, also for uterine to contract after labor bleeding put in rectum b/c vagina will bleed out |
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|
Term
Radiological treatment of severe post-partum bleeding |
|
Definition
uterine artery embolization or ligation with O'leary stitch |
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|
Term
what std is associated with inguinal lymhpodenapathY/ |
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Definition
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|
Term
painful ulcer painless ulcer |
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Definition
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|
Term
|
Definition
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|
Term
what STD presents with donovan bodies? |
|
Definition
granuloma inguinale (lymphogranula venereum) |
|
|
Term
what are some of the microbes (3) that cause purulent, non-gonoccocal urethritis? |
|
Definition
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|
Term
This STD is many times asymptomatic in females, but symptomatic in males |
|
Definition
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|
Term
Gonorrhea is a gram____, ____cellular, ____cocci |
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Definition
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|
Term
All cervical cancer patients have _____ |
|
Definition
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|
Term
HPV infection is also present in 90% of these types of cancers |
|
Definition
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|
Term
Which serotypes of HPV are most common |
|
Definition
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|
Term
How long does it take for viral clearance of HPV |
|
Definition
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|
Term
If someone has a monogamous relationship and gets HPV, is this a sign of unfaithfullness? |
|
Definition
NO, hpv can be dormant for many years before it shows up |
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|
Term
Can hepatitis B be transmitted sexually? |
|
Definition
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|
Term
By what mechanism does the uterus grow in the first trimester? the second trimester? |
|
Definition
progesterone, estrogen mechanical distention |
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|
Term
What are braxton-hicks contractions |
|
Definition
irregular, painless contractions that are not real contractions of labor |
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|
Term
What is the source of progesterone during early pregnancy? Maximum at? |
|
Definition
corpeus luteum; 6-7 weeks |
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|
Term
|
Definition
not a tumor but is very large and releases androgens! |
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Term
|
Definition
patches of tissue on uterus that can cause pre-term bleeding |
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|
Term
In which way is the uterus rotated during pregnancy |
|
Definition
dextrorotation (to the right) |
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Term
|
Definition
cyanosis of vagina, cervix b/c of estrogen and an early sign of pregnancy! |
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|
Term
Vaginal changes during pregnancy |
|
Definition
increased secretions, vascularity, length |
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|
Term
what bacteria keeps the vagina at a low pH during pregnancy |
|
Definition
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|
Term
What is typical of urine contents during pregnancy? |
|
Definition
Increased glucose and AA, thus increasing susceptibility to a UTI |
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|
Term
Which side of the pregnant women will the ureters and renal pelvis be dilated? |
|
Definition
right side, b/c of sigmoid colon |
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|
Term
the right ovarian artery/vein empties into.... the left empties into... |
|
Definition
aorta, IVC Renal Artery/vein |
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|
Term
Changes during pregnancy: RPF GFR FF (filtration fraction gfr/rpf) clearance of creatinine |
|
Definition
all increase except FF (rpf increase greater then gfr increase) |
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|
Term
renal changes: BUN and Creatine uric acid plasma osmolality sodium renin/angiotensin |
|
Definition
decrease decrease (except in pre-eclampsia) decrease increase increase |
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|
Term
Is there hyper or hypo secretion of respiratory fluids in mother? |
|
Definition
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|
Term
What happens to the tidal volume of mother? How do the kidneys compensate? |
|
Definition
Increase in tidal volume, causing respiratory alkolosis with metabolic compensation (increased bicarb clearance) |
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|
Term
What does the decrease in blood CO2 pressure allow for? |
|
Definition
increased CO2 transfer from fetus to mother |
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|
Term
supine hypotension syndrome |
|
Definition
When the mother is in the supine position (laying down), aortic/vena cava becomes compressed and causes hypotension |
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|
Term
Besides an increase in tidal volume, what also increases in pregnant mom? |
|
Definition
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|
Term
how much does cardiac output increase? When is it maximal? |
|
Definition
30-50% (Stroke volume x heart rate) maximal at 10 weeks gestation |
|
|
Term
what happens to blood pressure of mom during pregnancy? |
|
Definition
increases at first but will decrease (because of decreased arterial resistance) in 2nd trimester and normal levels by term |
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|
Term
What happens to venous blood pressure |
|
Definition
increase in lower extremities only, causing swelling, varicosities, hemorrhoids |
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|
Term
Why is there a 10-20% increase in cardiac output immediately after delivery? |
|
Definition
associated with reflex bradycardia |
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|
Term
Hematological changes: hematocrit wbc platelets |
|
Definition
decrease ( dilutional effect of maternal plasma volume increase) increase decrease a little |
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|
Term
How much does the maternal plasma vloume increase? |
|
Definition
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|
Term
What happens to RBC mass of mother? |
|
Definition
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|
Term
Changes in mother during pregnancy: t-wave murmurs heart sounds |
|
Definition
flattening ejection murmur s3 heard |
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|
Term
What is the total requirement of iron during pregnancy? How much per day? Does maternal deficiency lead to reduced stores in the fetus |
|
Definition
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|
Term
|
Definition
can't stand taste of own saliva softening of gums and epulis gravidarum may also occur (tissue on gums) |
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|
Term
What are some of the GI changes during pregnancy? |
|
Definition
slower emptying (increased constipation) slower emptying of gall bladder (cholestastis of pregnancy) |
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|
Term
|
Definition
|
|
Term
striae gravidarum why hyperpigmentation? chloasma linea nigra |
|
Definition
strech marks increase MSH mask of pregnancy darkening of linea alba |
|
|
Term
|
Definition
decrease in estrogen and progesterone levels |
|
|
Term
Growth hormone change during pregnancy? |
|
Definition
|
|
Term
thyroid size? iodine uptake? TBG? |
|
Definition
all increase (free portion of T3-4 stays same) |
|
|
Term
What happens to the beta cells of mother during pregnancy? |
|
Definition
|
|
Term
Human placental lactogen has what effect on mother |
|
Definition
causes insulin resistance |
|
|
Term
What type of antibody can be transmitted to fetus via breast milk/cross placenta? |
|
Definition
|
|
Term
What does progesterone do in the hypothalamus regarding fat content? |
|
Definition
resets lipostat, increasing fat storage |
|
|
Term
What is the major nutrient of fetus, that cannot be endogenously produced? |
|
Definition
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|
Term
HPL from fetus has what effect on fatty acids in mother? |
|
Definition
increases free fatty acids, causes increase in ketone bodies in mother |
|
|
Term
When is fetal insulin present? |
|
Definition
|
|
Term
Is the rate of diffusion of fats high or low to placenta? |
|
Definition
|
|
Term
Explain course of blood flow in fetal circulation. |
|
Definition
NUTRIENT RICH BLOOD Umbilical vein source of nutrient-rich blood skips liver via ductus venosus and enters IVC nutrient rich blood skips right ventricle (foramen ovale) and goes to aorta/carotids NUTRIENT POOR BLOOD main source is superior/inferior vena cava, goes through right ventricle ductus arteriosis allows blood to then enter descending aorta and out hypogastric arteries and go out through umbilical artery! |
|
|
Term
FHR @ first trimester: FHR 2nd and 3rd: |
|
Definition
|
|
Term
Respiratory epithelium and bronchioles don't develop until... |
|
Definition
|
|
Term
Amniotic fluid is key for development of what? |
|
Definition
|
|
Term
what is the purpose of surfactant? |
|
Definition
decreases surface tension to prevent hyaline membrane disease |
|
|
Term
what is surfactant derived from? |
|
Definition
lecithin and phophatidylglycerol |
|
|
Term
what is the lecithin/sphingomyelin ratio |
|
Definition
|
|
Term
when does phosphatidylglycerol need to be present? |
|
Definition
|
|
Term
early decels variable decels late decels |
|
Definition
head compression (normal) cord compression utero/placenta defect (bad) |
|
|
Term
what is the difference between fetal hemoglobin and maternal hemoglobin? |
|
Definition
has 2 gamma chains that increases affinity for oxygen..also it is 18gm/dl in fetus (elevated) decreased affinity to 2,3 BPG |
|
|
Term
is fetal urine hyper or hypotonic |
|
Definition
|
|
Term
what can the fetal kidney do better than adult? |
|
Definition
increased glucose absorption |
|
|
Term
what causes polyhydramnios? |
|
Definition
if baby does not swallow (up to 450cc/day at term) will account for larger stomach |
|
|
Term
What is treatment for uterine cancer? |
|
Definition
surgical and may require postoperative radiation therapy |
|
|
Term
what is the definition of menopause |
|
Definition
cessation of menses for a year |
|
|
Term
What is common about FSH and LH levels in a woman without a uterus? |
|
Definition
|
|
Term
do eggs develop into the antral stage during perimenopause? (5 years prior) |
|
Definition
|
|
Term
When cycles are 45 days, how long until menopause? |
|
Definition
|
|
Term
Do FSH levels increase or decrease a year before menopause? |
|
Definition
increase, as do estradiol levels |
|
|
Term
what happens to FSH/LH levels after menopause |
|
Definition
both increase, FSH to 25-30 and LH is more variable |
|
|
Term
When does menopause begin for.... smokers undernourished alcohol |
|
Definition
|
|
Term
Hot flashes caused by the decline of ______ and is always preceded by _______ |
|
Definition
|
|
Term
what happens to the pH level in a post menopausal women? |
|
Definition
they increase, increasing the susceptibility to vaginosis |
|
|
Term
Does menopause cause depression? |
|
Definition
no but it can aggravate it, prozac is a therapy for hot flashes anyways |
|
|
Term
|
Definition
reduce risk of CV disease higher HDL levels prostacyclin and nitrous production inhibits oxidation of LDL supresses osteoclasts aids in absorption of calcium and Vitamin D increase number of vitamin D receptors on osteoblasts |
|
|
Term
loss of estrogen leads to _____osteoclastic activity because the osteoclasts will have a _____response to parathyroid hormone |
|
Definition
|
|
Term
Bone mass is dependent on..... |
|
Definition
calcium intake before the age of 19 |
|
|
Term
What is a common vertebral problem in woman over age of 65? |
|
Definition
50% will have vertebral compression fractures |
|
|
Term
A woman is ____times more likely to have endometriosis if within immediate family and these endometrium (either eutopic or ectopic) is resistant to _______. |
|
Definition
|
|
Term
The _____responsible for shedding endometrium during menses dont' work in patients with endometriosis. |
|
Definition
|
|
Term
What hormone is responsible for the development and growth of endometriosis? |
|
Definition
estrogen dependent (aromatase activity in the endometrium seen in these patients) |
|
|
Term
what are some of the changes seen in the macrophages/monocytes of endometriosis patients? NK cells? |
|
Definition
secrete growth factors instead of destruction overexpression of inhibitory receptors |
|
|
Term
endometriosis is found in ____% of infertile woman |
|
Definition
|
|
Term
Endometriosis patients have _____peak estrogen levels |
|
Definition
|
|
Term
what is the risk of endometriosis in black woman? asian? mean age of diagnosis? |
|
Definition
|
|
Term
symptoms of endometriosis |
|
Definition
new, progressive, sever pain pain dull and aching painful intercourse with deep penetration, worse before menses |
|
|
Term
|
Definition
ovarian cysts containing menstrual fluid |
|
|
Term
what is a treatment option for endometriosis? |
|
Definition
danazol (testosterone derivative) |
|
|
Term
what is the evil twin of endometriosis? |
|
Definition
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Term
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Definition
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Term
where is adenomyosis only found (in what woman) |
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Definition
women who have had children |
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Term
what are some of the symptoms of adenomyosis? |
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Definition
painful and frequent menses |
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Term
how can you distinguish adenomyosis from endometriosis? |
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Definition
adenomyosis does not respond to hormonal stimuli, normal age is 40 years, tender and boggy uterus |
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Term
what is the only treatment for adenomyosis? |
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Definition
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