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Nutriton Final
final: everything after 2nd test
262
Health Care
Professional
09/06/2012

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Term
Diabetes mellitus is a group of chronic diseases when the body does not produce or respond to insulin thus affecting metabolism of what?
Definition
carbohydrates
protein
fat
Term
Type 1 diabetics are what?
Definition
insulin dependent
-this is immune mediated or idiopathic
Term
What are the symptoms of DM type 1 at diagnosis?
Definition
lean
polydipsia
polyuria
hyperglycemia
electrolyte disturbances
ketoacidosis
length of onset
Term
Does it take a while for pts with DM1 to have symptoms?
Definition
yes.
Term
What 6 factors contribute to the etiology of DM1?
Definition
genetic
insulin deficiency
islet cell destruction
autoimmune dz
external factors
improvement prior to deterioration
Term
What factors accompany the occurrence of DM2?
Definition
obesity
age
genetics
past medical history
physical activity
Term
In DM2, there are no formation of what? What actually does contribute to glucose intolerance?
Definition
no formation of antibodies.
antibody formation is not involved in glucose intolerance in DM2
-genetics and environmental factors actually do contribute to glucose intolerance.
Term
What are 3 possible defects in DM2?
Definition
Abnormal insulin secretion (or insulin resistance)
Reduced glucose uptake
Increased AM fasting glucose
Term
What is the most common type of diabetes mellitus?
Definition
DM2
Term
What are the various categories of glucose intolerance?
Definition
other diseases/ steroid use
malnutrition
impaired glucose intolerance
gestational diabetes (high incidence of fetal mortality)
injury and stress of trauma
severe trauma
pancreatitis
cystic fibrosis
Term
For the dx of DM to be made, what is the fasting glucose? what is normal?
Definition
>126 mg/dl
<115 mg/dl
Term
What other tests are sued to diagnose DM?
Definition
Plasma glucose > 200 mg/dl with symptoms
Oral glucose tolerance test
Term
What are the goals of DM management?
Definition
to prevent or delay complications
weight control
medical nutrition therapy
glycolated hemoglobin tests
blood glucose levels
lipid levels
Term
What are some complications of DM?
Definition
vasciular
renal
GI
retinopathy
CVD
Term
One of the GI complications of DM2 is gastroparesis, explain what happens?
Definition
Gastroparesis develops bc the nerves are dying
-so the diabetic will not empty their food out well
-the thing you digest the quickest is carbs then protein then fat
-diabetic products are high fat, so if a person with gastroparesis eats these high fat products they will have a lot of vomiting and diarrhea
Term
What is the hgb-A1C goal for a non-diabetic?
for a diabetic?
Definition
4-6
<7
Term
With an A1C of 6, blood sugar is ~126.
So, if blood sugar is in the 150 range what will A1C be?
Definition
like 7
for every 27 or 28 increase in the blood glucose level, the A1C will go up.
Term
The management of DM involves a consistent food plan that ha been individualized to lifestyle and calorie requirements via what 2 methods?
Definition
CHO counting
Exchange system
Term
How does CHO counting work?
Definition
15 g CHO = 1 CHO choice
-then determine total CHO per meal
Term
What foods have carbohdrates in them?
Definition
fruit
starches
milk
grain
Term
What is the diabetic diet now called?
Definition
consistent carbohydrate diet
Term
How are carbs and calories distributed to various pts?
Definition
almost everyone is given the same amt of calories, but are given carbs in a specific pattern
Term
What is the mgmt strategy for DM1?
Definition
consistent intake (should not vary more than a half hour from day to day)
timing of meals
insulin adjustments (like when planning on intaking a bunch of sugar)
monitoring of BG levels
multiple injections
Term
What is the mgmt strategy for DM2 pts?
Definition
*these strategies are more related to getting normal blood glucose levels, weight loss, triglyceride level goals
-start off on diet alone, then meds, then injections.
normal BG levels
normal lipid levels
weight loss/ maintenance
exercise
behavior modification
fat intake
medications
Term
What is the goal protein intake per day?
Definition
0.8g/kg/day
Term
What should the fat intake be like?
Definition
limit saturated fat
<30% of total calories
increased MUFA
Term
Which is better for you: MUFAs or PUFAs?
Definition
MUFAs
Term
Which is better for the DM pt: sweeteners or sugars?
Definition
sweeteners
Term
PUFAs are ____ oil. MUFAs are ____ oil.
Definition
corn
olive
Term
How should diabetic pts intake CHOs?
Definition
complex CHOs are better
avoid simple sugars
Term
What is the goal fiber intake for diabetics?
Definition
35 g/day
Term
Is sodium usually restricted in diabetics?
Definition
not usually unless they have a problem with edema and CHF
Term
Is there a need to supplement vitamins and minerals in diabetics?
Definition
no, but may be a good idea to supplement promium
Term
What are the 3 different types of insulin regimens?
Definition
conventional
intensive insulin therapy (MDIs)
continuous subQ insulin infusion (pump)
Term
The pump is usually used by DM1, if these pts are alert enough to manage their own pump does dietetics step in?
Definition
No
Term
What is the normal response to oral DM agents?
Definition
initially have a good response then a secondary failure.
Term
What is the usual duration of oral DM meds?
Definition
6-24 hours
Term
What are the 7 classes of oral DM meds + insulin? these are all different in their modes of action.
Definition
Alpha-Glucosidase Inhibitors
Amylin Analogs
Incretin Mimetics
Biguanides
Meglitinides
Sulfonyureas
Thiazolidinediones
Insulin
Term
What are the benefits of exercise in DM?
Definition
Weight control
improved insulin sensitivity
reduces CV risk factors
Term
There are potential problems when diabetics exercise, so what should they do to avoid problems?
Definition
proper BG monitoring
insulin dose adjustment
CHO loading
-exercising more than 40-60 mins drains the glucose
Term
How can some DM2 pts completely cure their condition?
Definition
bariatric surgery
Term
When a diabetic is CHO loading, what should they be loading with?
Definition
complex carbohydrates, not simple sugars
Term
What are some acute complications of DM?
Definition
Hyperosmolar Hyperglycemic Nonketotic Syndrome
Hyperglycemia
Hypoglycemia
SOMOGYI Effect
DAWN phenomenon
Term
What are some long-term complications of DM?
Definition
MACROVASCULAR
-Lipid abnormalities
-Hypertension

MICROVASCULAR
-retinopathy
-nephropathy
-neuropathy

Brittle DM- Dawn phenomenon in young children
Term
Why is renal failure one of the worst complications of DM?
Definition
it is the worst, most restrictive diet to follow.
Term
What is the Somogyi effect?
Definition
when have a reactive hyperglycemia then blood sugar drops.
-then given something for the hypoglycemia which makes them hyperglycemic
Term
What is the Dawn Phenomenon?
Definition
more with DM2
when sugars are really high in the liver
-liver releases glycogen while fasting, so can fix this with 1-2 carbs before going to bed at night
Term
What are the steps involved with the lifetime mgmt of diabetes?
Definition
assessment
goal establishment
implementation
evaluation
documentation
Term
How is a patient managed who has DM prior to pregnancy?
Definition
good control of sugars
have hypoglycemia risks and insulin requirements.
Term
_% of pregnant people get gestational DM, how should this be managed?
Definition
7%
diagnosis
diet
exercise
self-monitoring
Term
What is the goal for growth and development in children with DM?
Definition
3 meals with 2-3 snacks
constant re-evaluation as they grow

these kids can pretty much eat whatever bc their parent monitor their pump and they are constantly re-evaluated
Term
Why is the incidence of DM2 increasing in children?
Definition
due to obesity
Term
With DM2 in children what needs to be done?
Definition
lifestyle changes
assess HbA1C levels
may need metformin OHA
Term
What are some contributing factors of DM in the elderly?
Definition
Decreased insulin production VS increased insulin resistance

Medications

Physical activity

Genetics

Other illnesses
Term
What are the symptoms of hypoglycemia?
Definition
3 features of Whipple's Triad.
(1) neuromuscular signs with fasting or exercise
(2) low blood glucose levels associated with clinical signs
(3) reversal of clinical signs with the administration of glucose.
Term
What is the tx of hypoglycemia?
Definition
administration of some sort of carbohydrate
-give them 6-8 small feedings a day
encourage
-encourage a higher protein diet to prevent low drops of sugars
Term
When do people normally go hypoglycemic?
Definition
3-4 hrs after eating... may even have dumping syndrome where after they eat they have diarrhea
Term
Do we know the cause to hypoglycemia?
Definition
no. don't even know if people are true hypoglycemics.
Term
What is the mouth and esophagus used for?
Definition
mastication and swallowing
secretions (salivary and esophageal)
Term
Once you start to swallow, can you sstop?
Definition
Nope
Term
What is the function of mucous secretions in the esophagus?
Definition
to make it slick, does not have a protective mechanism
Term
The small intestine is the work horse of the GI tract, what does it do?
Definition
Digestion & absorption
Protein breakdown
CHO breakdown
Fat breakdown
Digestive juices
Hormones
Vitamins, Minerals, & drugs
Term
What does the liver contribute to the GI tract?
Definition
biliary secretions
bile
Term
What is the primary purpose of the large intestine?
Definition
to absorb water
-absorbs some minerals as well
Term
What is the bacterial action of the large intestine?
Definition
metabolizes fatty acids into short chain fatty acids
Term
Where does dietary fiber do all of it's job?
Definition
in the large intestine,
up until this point it is undugested
Term
Do some secretions protect the large intestine?
Definition
yes
Term
There are many reasons for tissue inflammation to be in the mouth, name some reasons
Definition
meds
age
illness
Term
What are the four inflammatory diseases of the mouth?
Definition
gingivitis
stomatitis
glossitis
cheilosis
Term
What can happen if gingivitis gets severe enough?
Definition
ulcerations can occur and abx are needed to clear up the infection
Term
What is stomatitis caused by?
Definition
chemotherapeutic agents
B vitamin deficiencies

with this, it hurts to eat anything
Term
What is glossitis?
Definition
Is the result of a B vitamin deficiency
-have a red swollen tongue
-with full blown glossitis, it looks like they don't have taste buds, tongue looks really smooth
Term
What is chelosis?
Definition
splitting in the corners of the mouth
-seen a lot in college age kids bc they aren't eating right
Term
What is the dietary tx with mouth disorders?
Definition
start out with softer foods and non-acidic things
-avoid temperature extremes
-chloriseptic spray is good before mealtime for numbing
-none of this will get any better without good nutrition
Term
Can you give someone with any of these mouth diseases a feeding tube?
Definition
no
-if really severe may give them a peg tube.
Term
Who has issues with poor dentition?
Definition
people on meth
Term
What is a reason for dentures not fitting anymore?
Definition
weight loss
Term
What is done for pts with too little salivary production?
Definition
given artificial saliva
-saliva is important for adequate mastication and formation of a good food bolus
Term
Can develop dysphagia after a stroke, head and neck surgery or long term feeding tube use... who do these pt then need to see?
Definition
a speech therapist
-Susan doesn't like speech therapists
Term
What is the easiest thing for people with dysphagia to swallow?
Definition
pudding and thicker liquids (Pureed)
-with water it goes down to quickly and aspration pneumonia can occure
-so be careful about ordering a clear liquid diet
Term
What is achalasia?
Definition
A DISEASE INVOLVING THE MOTILITY OF THE ESOPHAGUS. AFFECTS THE MUSCLE MOVING THE FOOD DOWN THE ESOPHAGUS
Term
What are the symptoms of achalasia?
Definition
regurg, chest pain, coughing, problems swallowing
Term
What does surgery for the mgmt of achalasia entail?
Definition
dilitation
-reduce pressure of the lower esophageal sphincter
-botox and meds
Term
What is the dietary mgmt of achalasia?
Definition
fatty foods
alcohol and peppermint/spearmeint lower LES pressure
smaller more frequent meals
Term
What are the symptoms of GERD?
Definition
Heartburn
dysphasia
nausea after eating
Term
With GERD, what kinds of foods should be avoided?
Definition
foods that decrease LES pressure- fat, alcohol, peppermint
-coffee and tea increase acid
Term
What meds are sued to tx GERD?
Definition
lifestyle changes
PPIs and H2 blockers
no aspirin or ibuprofen
-really don't use antacids anymore
Term
With GERD, want to _______ the sphincter. With achalasia, want to ______ the sphincter.
Definition
tighten
loosen
Term
What are 2 side effects of chronic esophagitis?
Definition
asthma
barrett's esophagus

both of these are closely related to esophageal cancer
Term
Chronic esophagitis has the same tx as what?
Definition
GERD
Term
What is the mgmt of hiatal hernia?
Definition
antacids
weight reduction
don't eat before you lie down flat
Term
How do you get a feeding tube past a hiatal hernia?
Definition
twist it.
Term
How do you manage cancer of the esophagus?
Definition
dietary changes
-then only take fluids and then take them to surgery
Term
What surgery is done on cancer of the esophagus?
Definition
esophegectomy
-body heals the tract pretty quickly
-bc these pts are generally malnourished
Term
With a pt with N/V, need to dig deeper into the cause, what could this cause be?
Definition
overeating
medications
Term
What are the causes of peptic ulcer dz?
Definition
aspirin and NSAID use
stress ulceration
H. pylori infxn

NSAID use is the most common cause.
Term
What is the therapy of PUD?
Definition
acid suppression through use of PPIs and H2 blockers

start them on 4 blands: 1-4
limit snacking: the more times you eat, the more you're going to stimulate the acid production
limit seasonings: red pepper, really spicy things
-maybe limit chocolate
Term
PUD is a disease of what organ?
Definition
stomach
Term
What are the 3 gastric surgeries?
Definition
vagotomy
partial/complete gastrectomy
gastric bypass
Term
What does a vagotomy do?
Definition
reduces acid secretion
slows gastric emptying
-may result in dumping syndrome

usually done for gastric cancer
Term
With a parital/complete gastrectomy, what would surgeons rather place?
Definition
a GJ tube
Term
What are the 3 types of gastric bypass surgery?
Definition
Roux-en-Y
-standard for weight loss (50-65%)
-biliopancreatic diversion (60-80% wt loss)
Billroth I
-gastroduodenostomy
Billroth II
-gastrojejunostomy
Term
What can Billroth I and II result in?
Definition
malabsorption, are only done when absolutely necessary
Term
What is dumping syndrome the physiologic response to?
Definition
the presence of larger amts of food than normal into the small intestine
Term
What procedures can cause dumping syndrome?
Definition
total or subtotal gastrectomy (no stomach, no holding cell for food before the mall intestine)
pyloroplasty
fundoplication
Term
What are the symptoms of dumping syndrome?
Definition
fullness and nausea
fluid shifts causing flushing, tachycardia, sweating, cramping, diarrhea and hypoglycemia
Term
What is the post-gastrectomy diet to avoid dumping syndrome?
Definition
limits simple carbs (sugar) and complex carbs (bread, fruit)
-beverages are given 30-60 mins after they eat real food.
Term
In the lower GI tract, what are 3 ways in which malabsorption can occur?
Definition
mechanical: missing part of GI tract (adhesions, surgical removal, obstructions)
-<270 M of small bowel is short gut

chemical: inadequate production of amylase or lipase, whipple procedure

solubilization: don't make enough bile salts can have fat malabsorption
Term
What 2 things can cause diarrhea in the lower GI tract?
Definition
diet: lack of appropriate fiber
lactose intolerance: AAs, asians, NAs and age
Term
What kind of diet do people with celiac sprue need to adopt?
Definition
gluten free
Term
What is celiac dz?
Definition
Permanent intestinal intolerance to dietary wheat gluten & related proteins that produces mucosal lesions in genetically susceptible individuals
Term
What are some general causes of celiac dz?
Definition
genetics
immune system
environment (bacterial or viral)
Term
What are the symptoms of celiac dz?
Definition
diarrhea (bulky, loos and watery)
weight loss (failure to thrive)
abdominal swelling and bloating with excess gas and abd pain
Term
How is celiac dz diagnosed?
Definition
antibody detection
intestinal bx
Term
What is the tx of celiac dz?
Definition
gluten free diet: eliminate foods containing wheat, barley, rye and oats
Term
What needs to be supplemented in people with celiac dz?
Definition
calcium
zinc
vitamin D
Mg
Vitamin B12
Term
Crohn's and UC are inflammatory diseases of what?
Definition
the lower GI tract
Term
Where does Crohn's occur?
Is it genetically associated?
What do the lesions become?
Are fistulas and strictures common?
At what age?
Definition
any part of the GI tract
yes
chronic
yes (
any age
Term
What is UC confined to?
Are the exacerbations more acute or chronic?
What does it only affect?
Definition
colon and rectum
acute
mucosa of the GI tract
Term
In crohn's, what makes the pts nonresponsive to tx? what do they then need?
Definition
fistula development
multiple resections
Term
What must UC be monitored for?
Definition
progression to cancer
-usually ends in colostomies or colectomies
Term
What is the drug therapy for IBD: Crohn's and UC?
Definition
Steroids and anti-inflammatories
-treated first with drugs, then to surgery and different types of resections
Term
What is the nutritional therapy of IBD?
Definition
TPN is no longer an accepted practice, so is EN
-every pt is different, and pt knows what foods bother them

high calorie, high protein diet
with inflammation: on a low residue diet (no milk or fiber)
when inflammation leaves, are put on a high fiber diet
Term
What are the nutritional risks and deficiencies present in IBD?
Definition
Iron
Folate
Nicotenic acid
Vitamin D
Vitamin K
Calcium
Magnesium
Zinc
Term
When UC pts are really inflamed, what do they have?
Definition
really bloody diarrhea
Term
Crohn's have lesions everywhere in GI tract, where are they most obviously seen?
Definition
mouth
Term
What is short bowel syndrome defined as?
Definition
jejunal + ileal bowel length of 100-200 cm
Term
What are the clinical symptoms of short bowel syndrome?
Definition
fat malabsorption
diarrhea
Term
What is the nutritional mgmt of short bowel syndrome?
Definition
TPN
3 adaptive stages
dietary strategies

many times are allowed to eat for the satisfaction of eating.
Term
With short bowel syndrome you have malabsorption of electrolytes, vitamins and trace elements of what 7 things?
Definition
iron
calcium
magnesium
fat soluble vitamins
zinc
B12
Folate
Term
What are the causes of diverticular dz?
Definition
low fiber diet
constipation
Term
What are the complications of diverticular dz?
Definition
abscesses
fistula
perforation
peritonitis
Term
How much fiber should someone with diverticulosis intake each day? what else should they intake more of?
Definition
20-35 g
water
Term
With diverticulitis, what is the mgmt?
Definition
clear liquids
low residue diet
surgery
Term
When does diverticular dz go from benign to not benign?
Definition
when the diverticuli start perforating bc all the e. coli and deadly junk on the inside of the GI tract gets into the sterile peritoneum--> can get into other organs and become deadly
Term
______________ is just treated wih a high fiber diet while ______________ might progress to needing surgery.
Definition
Diverticulosis
diverticulitis
Term
What is irritable bowel syndrome?
Definition
a functional intestinal disorder due to muscle spasms in response to food, gas and stress
symptoms include abd pain, constipation, diarrhea and bloating
Term
What id the nutritional tx of IBS?
Definition
individualized: eat slowly, high fiber, increased water, frequent small meals, decreased fat intake

deal with the stress!
Term
What are foods to avoid in a pt with diarrhea?
Definition
EtOH
caffeine
nicotine
gas producing foods
dairy
spicy food
high fat foods
sorbitol (in meds)
Term
What do you need to ask people who have diarrhea?
Definition
what does it look like?

if greasy and floating, probably have fat malabsorption
Term
What foods should be increased with constipation?
Definition
fresh fruits and vegetables
wheat bran
whole grain break and cereals
beans
increase slowly in diet
increased water consumption

avoid laxatives! unless are chronically on laxatives (but think about weening them off laxatives)
Term
How should fiber be increased in a diet?
Definition
gradually, if increase too quickly will get bloating, gas and diarrhea.
Term
What are the symptoms of viral hepatitis?
Definition
anorexia
weight loss
jaundice
Term
How is viral hepatitis treated?
Definition
rest
adequate fluid
adequate protein and high CHO
moderate fat (limit fat bc will probably have fat malabsorption)
supplementation of water and fat soluble vitamins (bc of fat malabsorption)
calories of 1.5 times basal needs.
Term
What is one of the most common types of liver dz?
Definition
alcoholic liver dz... usually results in poor nutrition
she also said hepatic steatosis (associated with obesity)
Term
What do pts with alcoholic liver dz need lots of?
Definition
calories... and 60-80 g/day of dry protein
Term
What is the progression of alcoholic liver dz?
Definition
fatty liver --> liver fibrosis --> cirrhosis
Term
What is the dietary tx of hepatic steatosis?
Definition
weight loss
avoid alcohol
mediterranean diet (anti-inflammatory)

primarily treated with diet
Term
What is the nutritional therapy of someone treated with cirrhosis?
Definition
Protein
-no flare up: normal amt of protein
-with flare-up: 150% of the protein they need to maintain muscle mass

Calories
-no flare up: 25% more calories
-with flare up: 50% more calories

CHO

Fat
-these people have malabsorption of fat.. given MCT (medium chain triglyceride) absorbed directly into lymph in order to get calories from fat

Sodium

Vit/Min

Alcohol
-NONE!

Fluid
Term
hepatic encephalopathy can either be acute or chronic, how is it treated?
Definition
Protein amount & sources
-start low, and increase to what they need
-adjusted by whether or not encephalopathy is progressing
Calories
Fluids
Vit/Min
Lactulose
-given to lower ammonia levels by making them malabsorb and have diarrhea
Term
Pts with hepatic failure will usually also go into what?
Definition
hepatorenal failure
Term
What are the 2 gall bladder diseases and their tx?
Definition
cholecystitis and cholelithiasis

surgical
-after 2-3 attacks, will take their gall bladder out
nutritional (limited fat and calories)
Term
How are pts with acute pancreatitis fed?
Definition
enterally: feeding tube into ligament of trietz (transpyloric)
-usually will use products high in MCT oil
-this is new, they used to just give the gut a rest
Term
Chronic panreatitis is more common, what type of pt can move to this?
Definition
diabetics
Term
Chronic pancreatitis is painful, and pts can become what?
Definition
drug dependent
Term
Feeding chronic pancreatitis pts is hard, what may have to be used?
Definition
IV nutrition
Term
If chronic pancreatitis pts do start eating again, what do they have to have?
Definition
NZ replacement.
Term
What is more common a problem, diarrhea or constipation?
Definition
constipation
Term
What is the most common GI dz?
Definition
diverticular dz
-main cause is constipation and low fiber diet.
Term
What is the nutritional therapy required for glomerulonephritis?
Definition
salt restriction
disease progression: protein, CHO, electrolytes, water
Term
There are multiple causes of nephrotic syndrome, what are some symptoms?
Definition
proteinuria
poor appetites
weight loss
Term
What is the nutritional therapy for nephrotic syndrome?
Definition
protein and calories!
sodium restriction
Term
In acute renal failure, dialysis is required... what are the 2 types of dialysis?
Definition
hemodialysis
CRRT
Term
What is the nutritional therapy of acute renal failure?
Definition
Protein: 1.0-2.0 grams/kg of actual/ideal weight

Energy: Begin at < 25 kcal/kg when critically ill then liberalize as needed

Electrolytes:Degree of restriction depends upon treatment
Term
What is the GFR for various stages of chronic kidney dz?
Definition
Stage 1: proteinuria: >90
Stage 2: mild damage: 60-89
Stage 3: moderate: 30-59
Stage 4: 15-29
Stage 5: <15
Term
What is the nutritional therapy of chronic renal dz?
Definition
Protein
Calories
Fluid
Sodium
Potassium
Phosphorus & Calcium
Vitamins / Minerals
Term
What is the tx of chronic renal dz?
Definition
dialysis
-hemodialysis
-peritoneal dialysis
-ultrafiltration
diet
fluid restriction
Term
What are you worried about with renal transplants?
Definition
immunosuppression
rejection episodes
Term
What nutritional therapy is required with a renal transplant?
Definition
Protein
CHO
Fat
Calories
Sodium
Term
What are the 4 types of kidney stones?
Definition
calcium
struvite
uric acid
cysteine
Term
What is encouraged with cystitis?
Definition
adequate fluid intake
cranberry juice- to coat the lining of the bladder making bacterial colonization more difficult
Term
How does nutrition play a role in cancer development?
Definition
mutations
chemical
radiation
viruses
epidemiological factors: diet, race, occupation
Term
Energy balance and exercise prevents what type of cancer?
Definition
colon
Term
Fat prevents what type of cancer?
Definition
breast
colon
lung
prostate
Term
Protein prevents what type of cancer?
Definition
colon and prostate
Term
Fiber prevents what type of cancer?
Definition
colon
rectum
breast
ovaries
Term
How do fruits and vegetables affect cancer?
Definition
contain antioxidants, phytochemicals
Term
CHO has an effect on what type of cancer?
Definition
pancreatic
Term
What else is linked to cancer?
Definition
alcohol
coffee and tea
artificial sweeteners
nitrates
Term
Cancer therapy includes what 5 things?
Definition
Surgery
Radiotherapy
Chemotherapy
Immunotherapy
Marrow Transplantation
Term
What is cancer cachexia?
Definition
alteration of metabolism resulting in subsequent death of the host
Term
What 5 factors lead to unintentional weight loss in cancer?
Definition
decreased nutrient intake from GI fxn related to direct tumor or adverse effects from treatment

obstruction/perforation of GI tract

Intestinal secretory abns

Anorexia (depression, food aversion, early satiety)

Nutritional consequences of tx
-chemo
-radiation
-surgery
Term
What are some metabolic changes induced by cancer?
Definition
protein
fat
glucose
energy expenditure
role of cytokines
Term
What are some nutritional parameters of cancer?
Definition
weight changes
body composition
lab values
nutrient intakes
Term
What are some feeding modalities with cancer?
Definition
oral
enteral
parenteral
Term
What nutritional requirements are you worried about with cancer?
Definition
calories
protein
fluid
vitamins and minerals
Term
Besides feedings, what are some other therapies of nutrition in cancer?
Definition
Metabolic Therapy
Macrobiotic Diet
Megavitamin therapy
Herbal therapy
“Cleansing therapies”
Term
What is the ideal appetite stimulant for cancer pts?
Definition
sustained positive effects on appetite
association bw agent use and repletion or maintenance of body cell mass
minimal adverse effects
no negative effects on tx
positive effects on QoL
Term
What are three types of appetite stimulants?
Definition
glucocorticoids
-short-lived effects
-adverse effects

cannabinoids
-increased appetite, decreased nausea

megestrol
-positive effect on appetite
-minimal increase in weight
-better long-term results.
Term
Have fish oils (antcytokine agents) proved effective in cancer pts?
Definition
no
-no differences in appetite or weight change
-no changes of measures of fxn or well-being
Term
Prevention with nutrition remains controversial, what foods are up for debate?
Definition
soy (breast and prostate cancer)

fruits and vegetables (GI and lung cancers)

tomatoes
garlic
vitamin D

alcohol- increases cancer risks

wine- contains compounds in grape skins that can help fight certain cancers

selenium- boosts body's antioxidant activity
Term
Parenteral nutrition...
Definition
safe and effective mode of nutritional support when delivered by strict protocols
Term
What are the indications for parenteral nutrition?
Definition
non-fxnal GI tract

bowel rest

severe malnutrition when pt will be unable to eat for more than 5 days
Term
What are the contraindications for parenteral nutrition?
Definition
tx required for less than 5 days

fxnal GI tract

inability to obtain venous access

prognosis
Term
When to initiate PN:
guidelines: ASPEN/CCM vs ESPEN
Definition
Term
Summarize the ASPEN/CCM guidelines.
Definition
If EN is not available, and the iCU pt is previously normally nourished, then PN can be started after first 7 days of hospitalization.

-if evidence of protein-calorie malnutrition on admission and EN is not feasible, then PN can be started as soon as adequate resuscitation is performed
Term
Under ASPEN/CCM guidelines, if the pt is expected to undergo major upper GI surgery and EN is not feasible, when should PN be provided?
Definition
-if pt is malnourished, PN should be initiated 5-7 days preoperatively and into the post-op period

-PN should not be INITIATED immediately after surgery, but should be delayed 5-7 days post-op if EN is not feasible

-PN should only be initiated only if the duration of therapy is anticipated to be >7 days, anything less than that will have no effect and could cause harm to the pt.
Term
Late initiation of parenteral nutrition is associated with a ______ recovery and ______ complications as compared with early initiation.
Definition
faster
fewer
Term
ESPEN says PN should only be used when?
Definition
when absolutely necessary
Term
What are the physiological limitations of PN?
Definition
atrophy of small bowel mucosa
decreased adaptive capacity
bacterial translocation
increased incidence of sepsis
Term
What are the types of access for PN?
Definition
Central Venous Access:
-subclavian vein preferred site (risk of PTX)
-internal jugular (more uncomfortable)
-groin: greatest risk of infection
-PICC

Implanted central venous catheters:
-for prolonged TPN access
-inserted operatively
-implanted in a subQ tunnel
-most common types: Hickman, Port-a-cath, Groshong
Term
What are some complications of PN?
Definition
Pneumothorax
Artery injury
Catheter malposition
Infection: Local & systemic
Air embolism; catheter embolism
Catheter occlusion
Venous thrombosis
Term
When prescribing for PN, what do you need to assess for?
Definition
nutritional risk
nutritional needs: protein, fat, CHO, fluids, electrolytes, vitamins, minerals and trace elements.
Term
When delivering nutrients to the body's disposal system, what do you NOT want to overload?
Definition
the body's disposal system.
Term
When delivering protein, what do you need to consider?
Definition
renal and hepatic fxn
Term
When delivering CHO, what do you need to consider?
Definition
200g required for nitrogen utilization
-oxidative limit of 7g/kg/day
Term
When delivering fat, what do you need to consider?
Definition
hyperlipidemia
-limit to <30% total calories
Term
When delivering fluids, what do you need to consider?
Definition
evaluate CHF
pulmonary edema
renal insufficiency
ARDS
Term
what is the composition of proteins when prescribing PN?
Definition
Synthetic crystalline amino acids
Solutions may lack certain AA due to instability
Solutions contain varying amounts of electrolytes
Concentrations depend upon final volumes
Hypertonic solutions
Term
What is the composition of dextrose when prescribing PN?
Definition
5%-70% solution dextrose in water
3.4 kcal per gram
Most abundant component in TPN
Component with the greatest effect on the hypertonicity of the solution
Term
What is the composition of lipids when prescribing for PN?
Definition
Should have < 30% as total calories
Sources are soy or safflower oils
Linoleic acids are precursors to prostaglandins (immunosuppressive, vaso-constrictive)

Structured and fish oil parenteral lipids not approved for use in this country
Term
What is TNA?
Definition
Total Nutrient Admixture
"three-in-one" solutions
Term
What is TNA composed of?
Definition
amino acids and dextrose with lipids piggybacked into the solution
Term
What vitamins and trace elements is PN composed of?
Definition
Vitamin A
Vitamin D
Vitamin E
Ascorbic acid
Folate
Niacin
Thiamine
Riboflavin
B 6
B 12
Pantothenic acid
Biotin
Vitamin K

Trace Elements:
Zinc
Copper
Chromium
Manganese

Selenium
Term
What vitamins and trace elements is PN composed of?
Definition
Vitamin A
Vitamin D
Vitamin E
Ascorbic acid
Folate
Niacin
Thiamine
Riboflavin
B 6
B 12
Pantothenic acid
Biotin
Vitamin K

Trace Elements:
Zinc
Copper
Chromium
Manganese

Selenium
Term
What can be added into PN?
Definition
Insulin
H2 Blockers
Heparin
Additional vitamins and minerals
Term
Initially, how is PN nutrition administered? then what occurs after tolerance is established?
Definition
over 24 hours
-consider cyclic TPN (in anticipation of home TPN)
--12-26 hr cycles
--usually night infusions
Term
What GI complications can occur with PN?
Definition
Fatty liver
Cholestasis
GI atrophy
Term
What metabolic complications can occur with PN?
Definition
Electrolyte imbalances (Na and K)
Glucose intolerance
Hypertriglyceridemia
Dehydration
Fluid overload
Prerenal azotemia
Mineral imbalances (Ca, Mg, P)
Overfeeding (Hypercapnia)
Essential fatty acid deficiency

Mineral imbalances
Calcium
Magnesium
Phosphorus
Overfeeding
Hypercapnia
Essential fatty acid deficiency
Term
How should these metabolic complication be monitored?
Definition
daily chemistries until electrolytes are stable
fingerstick blood glucose levels 4-6 times daily
fluid balance
live fxn tests weekly
WBC and temperatures daily
Term
How can PN's nutritional values be monitored?
Definition
lab data: prealbumin, total lymphocyte count, serum albumin of limited value

daily weights

nitrogen balance, if available
Term
Enteral Nutrition... if the gut works and can be used safely, use it!
Definition
Term
What are the physiologic benefits of enteral nutrition?
Definition
nutrients are metabolize and utilized more effectively

can be used in most cases of gastric and colonic dysfxn, bc small bowel function is maintained.
Term
What are the immunologic benefits of enteral nutrition?
Definition
maintains gut integrity
prevents bacterial translocation from the gut (systemic sepsis and increased risk of multiple organ failure)
Term
What are the biochemical benefits of enteral nutrition?
Definition
many formulas contain glutamine (which is the preferred gut fuel during metabolism)

many formulas contain fiber that stimulate mucosal growth in the GI tract
Term
What are the metabolic benefits of enteral nutrition?
Definition
decreased catabolic response after injury or stress if fed through the GI tract

stimulates production of hormones for gut mucosal growth
Term
What are the safety benefits of enteral nutrition?
Definition
avoids complications associated with line placement
Term
What are the cost benefits of enteral nutrition?
Definition
less expensive than PN
Term
what are the 2 contraindications of enteral nutrition?
Definition
malfunction of the GI tract
end-stage illness where harm exceeds benefit
Term
What are some examples of malfunctions of the GI tract that would result in the contraindication to enteral nutrition?
Definition
short bowel syndrome with inadequate length of jejunum and ileum present

mechanical obstruction of the GI tract
-sometimes can feed below it, but if too low may need to do IV nutrition

prolonged ileus

severe GI hemorrhage

Intractable vomitting

high output fistula (may be able to feed below it if it is high enough)

pancreatic pseudocyst
Term
Lately, does Susan do enteral feeding for anyone with a pancreatic issue?
Definition
No
Term
If are receiving enteral feeding for <4-6 wks, what placement should be used?
for >4-6 wks?
Definition
nasoenteric placement
surgical placement
Term
What are usual placements for the end of an EN tube?
Definition
gastric
bowel
Term
What does PEG stand for, and what kind of feeding is it used for?
Definition
Percutaneous Endoscopic Gastrotomy
Enteral feeding
Term
___________ are easy to place and are pretty short.
Definition
Nasogastric
Term
What are the placement issues with a nasoduodenal tube?
Definition
blind placement
fluoroscopic placement
Term
Which feeding tubes have to be surgically placed?
Definition
Percutaneous Endoscopic Gastrostomy
Button Gastrostomy (peds)
Jejunostomy
Term
Where are you usually trying to get the feeding tube to?
Definition
ligament of trietz
Term
What 5 things should be kept in mind when prescribing enteral nutrition?
Definition
Meeting nutrient requirements
GI tract function
Past Medical History
Disease state
Constraints on nutrient delivery
Term
What are the formula types and composition?
Definition
Polymeric
Defined formula
Disease- Specific
Modular
Term
What composes the polymeric enteral formula?
Definition
-complex source of CHOs, protein and fat
-requires normal digestion and absorption
-most are lactose free
-available in a calorically dense form (1.5-2kcal/cc)
Term
What composes the defined formula?
Definition
protein is hydrolyzed to peptides or aas

% of fat may be as MCT or as fish oils

minimal digestion required

may have a high osmolarity

available in a calorically dense form
Term
With the disease specific enteral formula, what diseases does it include?
Definition
renal failure
liver failure
pulmonary dz
malabsorption/GI dz
diabetes
sever trauma/ injury
Term
What is in the renal failure specific formula?
Definition
CRT- continuous renal therapy
-is a dialysis
-gradually increase protein
-give them whatever they need, bc they are just going to filter it out
Term
Why are liver failure specific formulas the last resort?
Definition
really pricy
Term
With pulmonary dz specific formulas, which will you probably be in more contact with?
Definition
ARDS
-there is some controversy around pulmonary specific formulas
Term
What is in the diabetic specific formula?
Definition
high fat
low CHO
moderate protein
"Glucerna", keep in mind gastroparesis problems though
-worried about vomiting and aspiration with tube fed pts.
Term
Is it good to put a critically ill pt on a high fat diet?
Definition
No, maybe wait til they are out of the ICU
Term
What is the enteral formula for a pt with severe trauma and injury?
Definition
very specific: high protein, extra arginine, zinc and vitamin A for wound healing

-these formulas are pricy, and pts are not sent out of the hospital while on them
Term
What is the modular formula composed of?
Definition
single nutrients
-combined to make a formula customized to each pt.
-may be added to oral supplements or to enteral feedings
-added to enhance healing/recovery
Term
True or False: Enteral feedings should not be started until the GI tract is functional as identified by bowel sounds, bowel movements or “low” gastric residual volumes
Definition
False
Term
True or False: Nothing can be started until hear bowel sounds, pass gas or see stool.
Definition
False
Term
Summarize the Canadian Guidelines.
Definition
EN preferred over PN
EN: 24-48 hrs after admission to the ICU
Does not address the presence or absence of bowel sounds

Initiate a feeding protocol that includes:
-prokinetics
-a higher GRV of 250 mL
-postpyloric feeding tubes
Term
When including a higher GRV of 250 mL what should be started with signs of intolerance?
Definition
metoclopramide
Term
When are posrpyloric feeding tubes recommended?
Definition
routinely in critical care

for selected pts having persistent elevated GRVs or those at risk for aspiration and pneumonia
Term
When are post pyloric feeding tubes recommended?
Definition
routinely in critical care

for selected pts having persistent elevated GRVs or those at risk for aspiration and pneumonia
Term
When may EN be started after adequate fluid resuscitation?
Definition
24-48 hrs following injury or admission to the critical care unit
Term
When may EN be started after adequate fluid resuscitation?
Definition
24-48 hrs following injury or admission to the critical care unit
Term
How does the American Dietetic Association stand on evaluating GRVs?
Definition
Monitoring GRVs is an option to assess EN tolerance
-hold EN when GRV>250 mL documented on 2 consecutive occasions
-use promotility agents if pt has gastroparesis or persistently elevated GRVs
-EN infused into the stomach is acceptable for most pts; small bowel feeding preferred with signs of intolerance

DOES NOT address presence of bowel sounds/movements

So:
GRV recs: consensus/imperative
promotility agents: strong/ conditional
small bowel FT: fair/ conditional
Term
read all the other guidelines in the enteral ppt.
Definition
Term
True or false: tap water can be used safely to flush feeding tubes and to dilute meds to be given per feeding tube.
Definition
false
-use of sterile water is preferred for safety
-meds should be given mixed in sterile water through feeding tubes
Term
How should medications be given through feeding tubes?
Definition
one at a time
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