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Nutrition
Test 2
102
Science
Undergraduate 2
10/19/2009

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Term
Triglycerides
Definition

made up of fatty acids

c-c-c-c-c=O

              ^OH

Term
Esterification
Definition
making triglycerides (removes H20)
Term
De-estrification
Definition
adds H20 back
Term
Long chain fatty acids
Definition
>12 fatty acids; more carbons=less soluble in H20
Term
Medium chain
Definition
6 to 10 carbons
Term
Short chain
Definition
< 6 carbons
Term
Saturated fat
Definition
has max # of carbons it can hold
Term
Unsaturated fat
Definition
doesn't have the complete amount of carbons it can hold and it also contains a double bond
Term
Monounsaturated/polyunsaturated
Definition
only 1 double bond/more than 1 double bond
Term
Cis/Trans
Definition

natural/unnatural configurations

(h-h compared to h-c-c)

Term
Hydrogenating
Definition
adding an oxygen to the molecule-changes configuration
Term
Hydrogenating polyunsaturated fats leads to what?
Definition
trans fat-partially hydrogenated=REALLY BAD
Term
Essential fatty acids
Definition
  • acids that we need but can't make :
    • needed for making:
      • prostaglandins
      • leukotrienes
      • thromoboxanes
Term
What important processes do essential fatty acids carry out?
Definition
blood clotting and inflammation!!
Term
Fat cell
Definition

80% triglyceride, 20% water

-this stores a lot of energy

Term
Muscle cell
Definition

75% water, 25% triglyceride

-these can't store much energy

Term
Phospholipids
Definition

emulsifiers

-attempt to use mucelle

needed for making cell membranes

Term
Cholesterol
Definition
used to make testosterone, estrogen, corticosteroid, vitamin D
Term
Chylomicrons
Definition

these are picked up by the lymph system

-80 to 90% of it is composed of triglyceride

-it's a big fat droplet

Term
Apolipoprotein
Definition
responds to cell surface receptor when dealing with chylomicrons
Term
Lipase
Definition
This helps move the triglycerides into the cell (this is also what the cell receptor activates)
Term
Very Low Density Lipoprotein (VLDL)
Definition
chylomicrons become this as triglycerides are pulled out of the cell
Term
Describe VLDL's.
Definition
  1. very dense
  2. 50% triglyceride
Term
Describe LDL's.
Definition
  1. very high in cholesterol and low in triglyceride
  2. primary cholesterol transport in body
  3. when receptors stop  working, this will float around in your blood and cause problems if there is a build-up
Term
Oxidized LDL's
Definition
These can't be picked up by the cell because they are considered damaged.
Term
Antioxidants
Definition
These help slow down the rate of LDL oxygenation (helps prevent heart disease).
Term
Describe the scavenger pathway.
Definition

WBC's scavage oxidized LDL's

-overtime this forms plaque

 

Term
What two things does your body send into your blood stream due to the scavenger pathway?
Definition
Collagen and Calcium
Term
HDL
Definition

"good" cholesterol; scavages dead cells for cholesterol to send to the liver

-females=40mg/dl

-males=50mg/dl

Term
List some risk factors for CVD.
Definition
  • Can control                             -Can't control
    • genetics                               -smoking
    • gender/age                        -diet
    • ethnicity                               -obesity/BP
Term
How are proteins configured?
Definition
  • Made up of amino acids
  • "r" represents different sets of molecules depending on "basic, acidic, neutral" (basic amino acid)
  • an amino (2 H and N)
  • an acid (C double bonded to O and single bonded to OH)
Term
Transamination
Definition
This is the process of making and converting molecules to amino acids or changing them.
Term
Deamination
Definition
This is the process of removing "R" and replacing it with "O".
Term
Complete Protein
Definition
This contains all the essential amino acids in an adequate amount.  Egg whites would be the standard.
Term
Incomplete Protein
Definition
Protein missing 1 or more amino acids.
Term
Central Dogma
Definition
This is the information flow in a cell.
Term
Describe the information flow in a cell (central dogma).
Definition
  1. DNA in nucleus is transformed to RNA
  2. RNA is transcribed (T changes to U)
  3. The transcribed RNA is read by ribosomes and leads to protein

The three code sequence (AGC) is considered the condon.

Term
What is it called when two amino acids are joined together?
Definition
Dipeptide; ribosomes create a bond between them (removal of H20)
Term
Peptide bonds are composed how?
Definition
ATP-> ADP+Pi; use a lot of energy!!
Term
How many ATP's does it take to create protein?
Definition
10!!
Term
Name the 4 categories of structure.
Definition
  1. Primary Structure-twists itself
  2. Secondary Structure-helix
  3. Tertiary Structure-helix twists
  4. Quaternary structure-2 or more chains connect
Term
What does denatured mean and what causes it to occur?
Definition
Proteins are cooked; makes them easier to digest
Term
Describe the American diet in terms of animal vs. plant protein.
Definition

Animal-70%

Plant-30%

(opposite for the world)

Term
Biological value
Definition
efficiently using all the amino acids and little nitrogen should be present in wastes (difficult to calculate)
Term
Protein efficiency ratio
Definition
based on growth rate
Term
Chemical Score
Definition
looking at rations of amino acids in food; chemical score for a food compared to a chemical score for a standard; always take lowest value
Term
PDCAAS-Protein Digestability Corrected Amino Acid Score
Definition
chemical score x digestability; the result can be used to adjust daily vaules
Term
Balance of Nitrogen
Definition

positive: intake>excretion

negative: intake<excretion

-would like them to be equal

Term
The digestion of protein normally takes place in what area and how?
Definition
This takes place mainly in the stomach; pepsinogen is converted to pepsin (by the acid environment of stomach).
Term
The basics of proteins are what?
Definition
  1. stuctural
  2. maintains osmotic balance
  3. acid-base buffers
  4. hormones
  5. antibodies
  6. transportation
  7. energy pathways
Term
Protein Diseases
Definition

Protein and energy deficiency: marasmus; skin and bone appearance

protein deficiency: kwashiokor; swollen stomach appearance

Term
What are some side effects of a high protein diet?
Definition
  • tendency to overload kidneys with urea
  • will normally occur with animal protein
Term
Give some examples of protein allergies.
Definition
peanuts, eggs, wheat, milk
Term
What do vegetarian diets need to watch?
Definition
B-12 intake, calcium intake, zinc, and iron
Term
Alcohol
Definition

7 cal/gram

1 drink=15 grams of alcohol

80 proof=40% of alcohol

Moderate=1 drink/day for women and 2 drinks/day for men

Term
Fermentation
Definition
anaerobic process; yeast makes the alcohol-creates ethanol (uses glucose or maltose to ferment)
Term
Effects of Alcohol on the body
Definition
  1. absorbed through stomach and  SI(more common)
  2. all cells in the body are soaked by alcohol
  3. ethanol converts to acetaldhyde by alcohol dehydrogenose
  4. acetaldhyde converted to acetyl-CoA by acetalhyde dehydrogenase
Term
Microsomal Ethanol Oxidizing System (MEOS)
Definition
This helps with detoxing your body; if you drink too much, this kicks on and begins to oxidize alcohol (mainly in liver).
Term
Catalase Pathway (minor system)
Definition
results in why women should drink less; more body fat equals slower processing
Term
List some health effects of alcohol:
Definition

High levels of alcohol (14 drinks/week, 7 drinks/week)

  • cancer in oral cavity
  • heart arrhthymias
  • liver damage (cirrhosis)
  • niacin, B6,  B12 deficiencies
  • stomach ulcers
Term
Fetal Alcohol Syndrome
Definition
reduces mental capacities, poor brain development, effects neural tube, morphological changes
Term
What are the different types of metabolism?
Definition

-Anabolic: small to large

-Canabolic: large to small

 

Term
ATP is what?
Definition
Energy currency in cell
Term
How do you get energy out of ATP?
Definition
Bond is broken and ATP becomes ADP
Term
How do you make ATP?
Definition
  1. oxidation-reduction reactions: hydrogen oxidizes and oxygen reduces
Term
NAD and NADH
Definition
oxidized form/reduced form
Term
FAD and FADH2
Definition
oxidized and reduced
Term
List the firststages of glucose metabolism.
Definition
  1. glycolosis;glucose broken down into 2, 3-carbon molecules: glyceraldhyde 3-phosphate and dehydoxyacentone phosphate; glyceraldehyde is converted to pyruvate!!!
Term
List the second stage of glucose metabolism.
Definition
2. Pyruvate undergoes a transition reaction; loses CO2 and results in acetyl-CoA
Term
List the third stage of glucose metabolism.
Definition

3. Citric acid cycle; acetyl-CoA combines with oxaloacetate to produce citric acid; loses 2 carbons but produce:

-4 ATP

-10 NADH+H

-2 FADH

Term
List the fourth stage of glucose metabolism.
Definition

4. Electron transport: uses the products of the citric acid cycle and synthesizes  ATP

-oxidative pohsphorylation: ADP +Pi---> ATP!!

Term
How many ATP's are produced through glucose metabolism?
Definition
38-humans produce more during winter and less during summer
Term
Why does the electron transport being to stop when there is an increase concentration of ATP?
Definition
The increased amounts of ATP shunt straight to fatty acid metabolism if there is too much not being used.
Term
List the citric acid cycle.
Definition

-acetyl-CoA+oxaloacetate

-citric acid

-alpha ketoglutarate

-succinate

-fumarate

 

Term
Oxaloacetate can go straight back to pyruvate to produce glucose how? The process results in a glucogenic amino acid.
Definition
Amino acid group is chopped off using deamination to change to alpha-ketoglutarate and starts the cycle
Term
What is the difference between a ketogenic amino acid and a glucogenic amino acid?
Definition
Ketogenic amino acid's carbon skeleton cannot be used to produce glucose.
Term
Fat metabolism is what?
Definition
3 triglyceride molecules are broken down into free fatty acids
Term
Beta-Oxidation is what?
Definition
Cleaving the carbons off in pairs; this process produces acetyl-CoA
Term
What are ketone bodies used for and what can they cause if they are overabundant?
Definition
Brain uses them in place of glucose when there isn't enough; heart uses keton bodies to run on; in diabetics, if too many are present, blood become acidic
Term
What is alcohol metabolism?
Definition

ethanol-->acelatdehyde--->acetyl-CoA

-produces energy!

Term
MEOS does what for alcohol metabolism?
Definition
Uses energy to get to acetly-CoA and can metabolize ethanol
Term
What are two highly active antioxidants?
Definition
O- and H2O2 are highly reactive (MEOS generates a LOT of oxidative molecules)
Term
Can you make glucose from acetyl-CoA?
Definition
NO!
Term
Inborn error metabolism; PKU
Definition
PKU normally changes to tyrosine; can cause mental retardation if not treated; in this disease your body lacks enzyme to convert PKU
Term
What are the 2 energy balances?
Definition

1. positive=gaining weight

2. negative=losing weight

Term
Resting metabolic rate
Definition
resting, but not fasting; 6% higher than BMR
Term
Basal metabolic rate
Definition
fasting for 12 hours and resting
Term
What are some things that lead to increased BMR?
Definition

-increased muscle mass

-thyroid hormones

-growth stage

-nervous activity

Term
Thermic Effect of Food
Definition
Protein uses more energy to be digested than carbs; carbs use more than fat
Term
Discuss thermogenises (heat production).
Definition

Brown fat- found in babies, just for heat

BMR increases when you are really cold

-shivering and fidgeting

Term
High fructose corn syrup has led to what and how?
Definition
Leads to high levels of obesity; has the ability to bypass pathway and be generated straight to fat! This is also found in soda!
Term
What is direct calorimetry?
Definition
This measures the heat of water to determine how many calories were used in something (example of human in little room& scientists use the temp. of the water around the room)
Term
What is indirect calorimetry?
Definition
This measures expended calories by using oxygen.  Measuring stable isotopes measures this same thing.
Term
What are some of the aspects that lead to control of eating?
Definition
Hunger, apetite, and leptin (produced in fat cells; body produces this when cells get full)
Term
Body Mass Index
Definition

Height and weight tables: weight(kg)/height2(m)

Healthy-18.5 to 24.9

Overweight-25 to 29.9

Obese-30 and up

Term
What are some low density foods?
Definition
Carrots; diet soda vs. reg. soda
Term
List some ways to lose weight.
Definition

1. Food journal

2. Physical activity

3. Controlling behaviors (breaking the chain, stimulus to eat, congitive restructuring, contingency plan

4. Maintaining healthy weight (balance carbs&fat, eat breakfast, self-monitoring, physical exercise)

Term
Discuss fad diets.
Definition
Promise a quick fix, dire warnings about a food or substance, too good to be true, simplistic plan/conclusion, contrary to accepted facts/conclusions, selling a particular product, peer-reviewed, do not recognize individual differences
Term
Very low calorie diets
Definition
400-800 calories; monitored by docotor, usually only for morbidly obese patients
Term
What are some eating disorders?
Definition
anorexia nervosa (not eating), bulemia (binging then purging); usually psychological problems,
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