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required for optimal vision; retinoic acid essential for cellular growth and differentiation, also required for cell-mediated & antibody-mediated immune responses |
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maintain serum calcium & phosphorus levels;multiple possible functions through regulation of gene expression |
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antioxidant in cell membranes |
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cofactor for proteins involved in coagulation & some bone-associated proteins |
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night blindness, stages of xerophthalmia immune dysfunction 7 poor growth |
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nausea, vomiting, headache, bright red gingiva |
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is rare. kidney stones, dehydration, thirst |
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ataxia with progressive peripheral neuropathy |
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hemorrhagic disease of newborns; unreported toxicity from excessive Vitamin K intake |
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How retinoids regulate cellular differentiation |
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Definition
-retinoic acid binds to receptor on response element in promoter region of target genes resulting in activation of transcription |
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How Vitamin D maintain plasma calcium levels |
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-increase intestinal absorption of calcium -increase renal calcium reabsorption -increase calcium resorption from bone |
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How Vitamin E protects cell membranes from oxidative damage |
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-acts as antioxidant and peroxide scavenger particularly for cell membrane PUFAs and lipoproteins -breaks chain reaction of oxidation preventing propagation of free radical damage -regenerated to reduced Vitamin E by VItamin C |
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Etiologic factors contributing to hemorrhagic disease of the newborn |
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-coenzyme required for metabolism of carbohydrates & branched chain amino acids |
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-enzyme for multiple redox reactions, ATP synthesis and ADP-ribose transfer; significant amount of dietary tryptophan metabolized to NAD |
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-coenzyme in methyl group transfer reactions such as purine & pyrimidine synthesis and methylation of transfer RNA |
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coenzyme fro 2 critical enzymes involved in methyl group transfer |
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coenzyme for some redox reactions , hydroxylation of collagen, water-soluble antioxidant, neurotransmitter & neuropeptide synthesis, corticosteroid synthesis, serotonin synthesis |
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