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nutrition chapter 6
proteins
94
Nutrition
Undergraduate 1
04/28/2013

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Term
protein definition
Definition
large, complex molecules found in cells of all living things
synthesis controlled by genetic material (DNA)
Term
what do proteins contain?
Definition
carbon, hydrogen, oxygen, and nitrogen
Term
what are proteins made from?
Definition
from a combination of amino acids
Term
the portion of amino acid that means each unique is its _____ ______
Definition
side chain
Term
how many amino acids are most of the body's protein made of?
Definition
20 amino acids
Term
how are proteins made?
Definition
made of long chains of amino acids
Term
amino acids are connected by.....
Definition
peptide bonds
Term
how many essential amino acids are there?
Definition
nine essential amino acids
Term
essential amino acid
Definition
Cannot be produced in sufficient quantities to meet physiological needs

Must be obtained from food
Term
nonessential amino acid
Definition
can be synthesized in sufficient quantities
Term
names of essential amino acids (9)
Definition
Histidine
Isoleucine
Leucine
Lysine
Methionine
Phenylalanine
Threonine
Tryptophan
Valine
Term
Transamination
Definition
Transfer amine group from an essential amino acid to a different acid group and R group
Used to make nonessential amino acids
Term
conditionally essential amino acids
Definition
Nonessential amino acid becomes essential
Term
Phenylketonuria (PKU)
Definition
tyrosine becomes a conditionally essential amino acid that must be provided by the diet
Term
names of conditionally essential amino acids
Definition
arginine, cysteine, and glutamine
Term
Protein turnover
Definition
existing proteins are degraded to provide the building blocks for new proteins
Term
amino acid pool
Definition
includes amino acids from food and cellular breakdown
Term
What determines the function of protein?
Definition
Protein organization; sequential order of the amino acids; spiral shape from twist in amino acid chain
Term
Primary structure
Definition
the sequential order of the amino acid in a protein
Term
What causes the spiral shape in secondary structures?
Definition
Different amino acids in a polypeptide chain possess unique chemical attributes that cause the chain to twist and turn into a spiral shape

folding of H bonding
Term
Tertiary structure
Definition
the spiral of the secondary structure further folds into a unique 3-dimensional shape
Term
Quaternary structure
Definition
two or more separate polypeptides bond to form a larger protein
Term
Hemoglobin
Definition
protein in red blood cells that carries oxygen
Term
protein denaturation
Definition
affects their shape and function
proteins uncoil and lose their shape
protein function is lost
Term
damaging substances in protein denaturation
Definition
heat, acid, base, heavy metal, and alcohol
Term
protein function is lost in protein denaturation because
Definition
tertiary structure is gone
Term
denatured enzyme
Definition
high fever
blood pH out of normal range
Term
denaturation is desirable during....
Definition
digestion
Term
for protein synthesis, what must be available to the cell
Definition
all essential amino acids
Term
limiting amino acid
Definition
Essential amino acid that is missing or in the smallest supply
Slows down or halts protein synthesis
Term
Inadequate energy consumption
Definition
limits protein synthesis
Term
incomplete protein (low quality)
Definition
insufficient essential amino acids
Does not support growth and health
many plant sources
Term
complete protein (high quality)
Definition
sufficient amounts of all nine essential amino acids
Derived from animal and soy protein
Term
Mutual supplementation
Definition
combine two or more incomplete protein sources to make a complete protein
Term
incomplete protein source examples
Definition
Plant foods such as legumes, vegetables, cereals, and grain products

Beans – low in methionine
Rice – low in lysine
Term
Complementary proteins
Definition
two or more foods are combined to supply all nine essential amino acids for a complete protein
Term
food with limiting amino acid + foods high in limiting amino acid =
Definition
complementary protein food combinations
Term
protein digestion begins in the...
Definition
stomach
Term
Hydrochloric acid
Definition
denatures protein strands and activates pepsin
Term
Pepsin
Definition
enzyme that breaks down proteins into short polypeptides and amino acids
Term
Gastrin
Definition
hormone controls hydrochloric acid production and pepsin release
Term
protein digestion continues in the...
Definition
small intestine
Term
What completes protein digestion?
Definition
pancreatic enzymes (proteases)
Term
Cells in the wall of the small intestine complete breakdown of all ______ into single amino acids
Definition
polypeptides
Term
Peptidases
Definition
break peptide bonds
Term
amino acids are transported to the.....
Definition
liver
Term
What does the body uses as fuel sources?
Definition
fats and carbohydrates
Term
______ is saved for metabolic functions that cannot be performed by other compounds
Definition
protein
Term
Protein is used for the...
Definition
building and repair of body tissues
Term
_______ is used for fuel primarily when total energy or carbohydrate intake is low
Definition
protein
Term
Proteolysis
Definition
dietary proteins are digested into amino acids or small peptides
Term
When amino acids are transported to the liver, they...
Definition
Are made into proteins
Released into the blood for uptake by other cells for building and repair functions
Term
excess dietary protein
Definition
used for energy or stored as triglycerides
Term
Amino Acid utilization for energy begins with
Definition
deamination
Term
Ammonia from amino acid deamination
Definition
Used as nitrogen source for synthesis of nonessential amino acids
High levels are toxic
Liver converts it to less toxic urea
Term
name of energy pathways
Definition
glycolysis or TCA pathway
Term
Glucogenic amino acids are converted to...
Definition
pyruvate
Term
Ketogenic amino acids are converted to...
Definition
acetyle CoA by the TCA cycle
Term
cycle for the energy extracted from amino acids
Definition
amino acids-> carbon skeletons-> oxaloacetate or acetyl CoA or pyruvate or TCA cycle-> TCA cycle
Term
the body turns to its own tissues for energy during...
Definition
starvation
Term
methods for estimating protein quality
Definition
chemical score and PDCAAS
Term
chemical score
Definition
limiting amino acid compared to the amino acid in a reference food
Term
examples of highly digestible proteins (90+% absorption)
Definition
animal protein and many soy products
Term
functions of proteins
Definition
Cell growth, repair, maintenance, red blood cells
Enzymes and hormones
Fluid and electrolyte balance
Acid−base balance
Immune system
Energy source, deamination
Nutrient transport and storage
Term
Nitrogen balance determines....
Definition
protein needs and adequacy of intake for actual needs
Term
Example of positive nitrogen balance
Definition
growth periods
Term
Example of negative nitrogen balance
Definition
starvation or sickness
Term
Protein adequacy is calculated as
Definition
nitrogen intake – nitrogen excretion
Term
Example of in nitrogen balance
Definition
healthy adults
Term
RDA for protein
Definition
0.8 to 1.0g/ kg body weight/day
Term
recommended percentage intake for protein
Definition
10-35% of total energy intake
Term
protein needs are higher during.....
Definition
growth and development (children, adolescents, and pregnant/lactating women)
Term
how can too much protein be harmful?
Definition
causes high cholesterol and heart disease
Contribution to bone loss
Kidney disease
Term
animal-protein rich diets are associated with....
Definition
high blood cholesterol levels
Term
____ protein diets increase calcium excretion and possibly lead to bone loss
Definition
High
Term
Kidney disease
Definition
High protein intakes are associated with an increased risk among susceptible individuals
Term
What is the maximum safe amount of protein per kg of body weight for healthy people?
Definition
2 g of protein/kg body weight/ day
Term
Protein sources
Definition
Meats
Milk-based products
Soy products
Legumes (lacks Vit. B12)
Whole grains
Nuts (2-5 oz per week)
Quorn
Term
Vegetarianism
Definition
restricting the diet to foods of plant origin
Term
People chose vegetarianism for...
Definition
Health benefits
Ecological reasons
Religious reasons
Ethical reasons
Concerns over food safety
Term
Types of vegetarian diets
Definition
Semivegetarian (Flexitarian)
Pescovegetarian
Lacto-ovo-vegetarian
Lactovegetarian
Ovovegetarian
Vegan
Macrobiotic Diet
Fruitarian
Term
Health benefits of vegetarianism
Definition
Lower fat and total energy intake
Lower blood pressure
Reduced risk of heart disease
Fewer digestive problems
Reduced risk of some cancers
Reduced risk of kidney disease, kidney stones, and gallstones
Term
Challenges of vegetarianism
Definition
can be low in some nutrients
associated with disordered eating
varied and adequate diet planning
Term
Protein-energy malnutrition (PCM)
Definition
Caused by inadequate protein and energy intake
Swollen abdomen from excess fluid
Term
Marasmus
Definition
Grossly inadequate energy and nutrient intake
Term
Consequences of marasmus
Definition
Wasting and weakening of muscles (heart)
Stunted brain development and learning
Depressed metabolism
Stunted physical growth
Deterioration of the intestinal lining (anemia)
Severely weakened immune system
Fluid and electrolyte imbalances
Term
Kwashiorkor
Definition
Disease resulting from low protein intake
Term
Kwashiorkor symptoms
Definition
Some weight loss and muscle wasting
Retarded growth and development
Edema resulting in distention of the belly
Fatty degeneration of the liver
Loss of appetite, sadness, irritability, apathy
Skin problems and hair loss
Term
Examples of disorders that are caused by defective DNA
Definition
Phenylketonuria
Sickle cell anemia
Cystic fibrosis
Term
Phenylketonuria (PKU
Definition
Inherited disease
Cannot breakdown phenylalanine, which causes a build up in tissues and can cause brain damage
Term
Sickle cell anemia
Definition
Cells become crescent shaped causing them to become hard and sticky
Term
Cystic Fibrosis
Definition
Inherited disease affecting the respiratory system and digestive tract
Alteration of chloride transport in cells
Cells secrete a thick, sticky mucus
Term
symptoms of sickle cell anemia
Definition
Impaired vision, headaches, convulsions, bone degeneration
Term
symptoms of cystic fibrosis
Definition
wheezing, coughing, and stunted growth
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