Term
| Why is iodine in foods extremely variable |
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Definition
| it frelects regionally variable soil [] and the amount of fertilizer |
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Term
| Does river or sea fish have more iodide |
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Definition
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Term
| what are good protein sources of iodid |
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Definition
| milk and yogurt, egg, meats, and beans |
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Term
| how much iodid is obtained from 1/4 t iodized salt |
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Definition
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Term
| whigh gland contains majority of iodide |
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Definition
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Term
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Definition
| synthesis of thyroxine (T4) and triiodothyronin(T3) |
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Term
| three transport proteins that bind and transport thyroxine and 3,5,3'-triiodothyronine |
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Definition
1) thyroxine-binding globulin, found in plasma, has smallest capacity but greatest affinnit
2)albumin
3)thransthyretin |
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Term
| thyroid effects on metabolism |
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Definition
| stimulate BMR, O2 consumption, heat production, normal nervous system development and linear growth |
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Term
| waht affet do goitrogens have on thyroid hormone and/or iodine? |
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Definition
| substances that interfere with iodid metabolism in any way that inhibits thyroid hormonogenesis; effect is to 2* augment TSH release = thyroid enlargement; may affect iodide uptake by gland, organification of iodid, or hormone release from thyroid cells |
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Term
| three foods that contain goitrin |
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Definition
| cabbage, kale, cauliflower |
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Term
| major route of iodide excretion |
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Definition
| kidneys, b/e no mechanism to conserve it |
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Term
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Definition
| 150 micro g/day, higher for pregnant and lactating |
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Term
| how much iodide to prevent goiter |
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Definition
| 50-75 micro g/day or 1 micro g/kg body wt |
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Term
| relationship b/w thyrotropin releasing hormone, TSH, and thyroid hormone |
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Definition
| thyrotropin releasing hormone release from hypothalamus acts on pituitart to stimulate TSH secretion, and TSH increases activity of thyroid gland to generate T4 |
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Term
| what is characteristic feature of goiter? which hormone responsible? |
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Definition
| enlargement of thyrpid gland, caused by overstimulatione of TSH |
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Term
| what are symptoms of neurological cretinism, why would you find this and why? |
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Definition
| infants, b/e mom doesn't have enough iodide, symptoms: mental deficiency, hearing loss or deaf mutism, moter disorders such as spasticity, and muscular rigidity |
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Term
| how can we treat endemic goiter |
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Definition
| addition of iodine to table salt and administration of iodized oil or potassium iodide |
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Term
| assessment of iodide status |
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Definition
1)urinary excretion - based on ability of iodide to reduce cerric ion, yellow, to cerrous, which is colorlesss
2)serum [TSH]the quicker the uptake of radioactive iodide the greater the likelhood of deficiency |
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