Shared Flashcard Set

Details

NURS 280 Pharmacology
Chapter 4 Review
33
Pharmacology
Undergraduate 2
07/15/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
True or False
Pharmacokinetics describes how drugs change body responses.
Definition
False
Term
True or False
Absorption is generally faster across thinner membranes, compared with thicker membranes.
Definition
True
Term
True or False
Drugs more highly bound to plasma proteins are distributed more easily than drugs not bound to plasma proteins.
Definition
False
Term
True or False
Young and elderly clients usually metabolize drugs more slowly than middle-age clients.
Definition
True
Term
True or False
The main organs involved with excretion are the kidneys; however, other involved organs include the lungs, gallbladder, skin, and associated glands.
Definition
True
Term
True or False
A drug with a half-life of 5 hours will take longer to be eliminated from the body than a drug with a half-life of 10 hours.
Definition
False
Term
True or False
Factors influencing the success of drug therapy include drug dosing, frequency of dosing, and a changing medical condition.
Definition
True
Term
True or False
According to the receptor theory, most drug actions can be linked to a specific receptor.
Definition
True
Term
True or False
Drug antagonists are facilitators of drug action.
Definition
False
Term
True or False
The term potency refers to the ability of a drug to produce a more intense response as the concentration is increased.
Definition
False
Term
The four major areas of pharmacokinetics are _____, ________, __________, and _________.
Definition
Absorption
Distribution
Metabolism
Excretion
Term
___________ is a process whereby most drugs are deactivated when passing through the liver.
Definition
Metabolism
Term
Agents that become more active as they are exposed to detoxifying organs, such as the liver and kidneys, are called ___________.
Definition
pro-drugs
Term
A mechanism called the _____________ decreases the activity of most drugs traveling through the liver.
Definition
first-pass effect
Term
Breakdown products of drug metabolism are called _________.
Definition
metabolites
Term
Drugs secreted in the bile are often recycled in the liver because of a mechanism referred to as _________
________.
Definition
enterohepatic recirculation
Term
As discussed in the text, rate of elimination and ________ are two variables helpful in determining how long a drug will remain in the bloodstream and are thus indicators of how long a drug will last.
Definition
half-life
Term
____________ deals with how drugs affect body responses.
Definition
Pharmacodynamics
Term
The classic theory about the cellular mechanism by which most drugs produce a response is called the ________ theory.
Definition
receptor
Term
____________ is a drug’s strength at a particular concentration or dose, while __________ is the effectiveness of a drug in producing a more intense response as the concentration is increased.
Definition
Potency

efficacy
Term
Pharmacokinetics or Pharmacodynamics
Concentration (dose) of an administered drug

Presence of food in the digestive tract

Frequency of drug dosing

Age of client
Definition
Pharmacokinetics or Pharmacodynamics
Concentration (dose) of an administered drug
Pharmacodynamics
Presence of food in the digestive tract
Pharmacokinetics
Frequency of drug dosing
Pharmacodynamics
Age of client
Pharmacokinetics
Term
Faster or Slower Absorption/Distribution Rate
Warmer dispensing temperature
Absence of food in the digestive tract
Smaller surface area at absorption site
Binding of a drug to plasma proteins
Thin membranes (i.e., lungs)
Ability to mix with lipids
Chemically charged
Larger drug particle
Thicker membranes (i.e., skin)
Definition
Faster or Slower Absorption/Distribution Rate
Warmer dispensing temperature - Faster
Absence of food in the digestive tract - Faster
Smaller surface area at absorption site - Slower
Binding of a drug to plasma proteins - Slower
Thin membranes (i.e., lungs) - Faster
Ability to mix with lipids - Faster
Chemically charged - Slower
Larger drug particle - Slower
Thicker membranes (i.e., skin) - Slower
Term
The process of moving a drug from its site of administration across one or more body membranes is called:
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Definition
Absorption
Term
The process that describes how drugs are transported in the body is:
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Definition
Distribution
Term
The term used to describe how much of a drug is available to produce a biological response is:
A. Volume of distribution
B. Rate of elimination
C. Bioavailability
D. Half-life
Definition
Bioavailability
Term
The fact that the half-life of Drug A Is longer than of Drug B might be explained by a higher:
A. Metabolic rate for Drug A
B. Rate of elimination for Drug B
C. Potency for Drug A
D. Effectiveness of Drug B
Definition
Rate of elimination for Drug B
Term
One reason the first-pass effect is so important is that drugs absorbed at the level of the digestive tract:
A. Are circulated directly back to the heart
B. Are distributed to the rest of the body and their target organs
C. Have ultimately more bioavailability than they would if absorbed at a different location
D. Are routed through the hepatic portal circulation
Definition
Are routed through the hepatic portal circulation
Term
Drug doses are often ____________ when administered to children or the elderly.
A. Decreased to account for increased metabolism
B. Increased to account for increased metabolism
C. Decreased to account for decreased metabolism
D. Increased to account for decreased metabolism
Definition
Decreased to account for decreased metabolism
Term
The removal of larger drug metabolites from the bloodstream to the urine is referred to as:
A. Filtration
B. Reabsorption
C. Secretion
D. Recirculation
Definition
Secretion
Term
Which of the following statements is NOT correct regarding excretion by the lungs?
A. Factors that affect gas exchange influence the respiratory excretion rate.
B. The greater the flow of blood into lung capillaries, the greater the respiratory excretion rate.
C. Drugs easily converted to gases, such as ethanol, are especially suited for excretion by the respiratory system.
D. The lungs excrete most drugs as products of metabolism.
Definition
The lungs excrete most drugs as products of metabolism.
Term
For drugs easily dissolved in bile:
A. Enterohepatic recirculation significantly decreases the duration of drug action.
B. The entire drug amount is absorbed with the bile in the intestinal tract.
C. Drugs are not subject to metabolism by the liver.
D. A fraction of the drug amount is eliminated from the body through defecation
Definition
A fraction of the drug amount is eliminated from the body through defecation.
Term
Which of the following is most important regarding excretion mechanisms and the breasts?
A. Drugs excreted into beast milk may significantly harm the nursing infant.
B. The breasts are a modified type of sweat gland.
C. Urea and other waste products are eliminated naturally from the breasts.
D. Natural alternative agents are considered safe and are not excreted into breast milk.
Definition
Drugs excreted into beast milk may significantly harm the nursing infant
Term
Antagonists:
A. Are sometimes referred to as facilitators of drug action.
B. Can produce an effect only by interacting with receptors.
C. Inhibit or block the action of agonist drugs.
D. All the above.
Definition
Inhibit or block the action of agonist drugs.
Supporting users have an ad free experience!