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NUR 501 Foundations Exam#2 GI lecture
lecture from Mrs. Grimes-Robinson
65
Nursing
Graduate
06/23/2011

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Term
Peristalsis is___.
Definition
mechanical muscle movement of food through GI tract
Term
leaving the intestines, nutrients return to___, then enter into the blood stream
Definition
the liver
Term
From mouth to anus, the GI system is approximately __ft long from start to finish
Definition
30
Term
Starch digestion begin in the ____.
Definition
mouth
Term
The upper GI system is perfused by the ____ artery.
Definition
splanchnic
Term
The small intestine is perfused by the ___ & ____ arteries.
Definition
hepatic & superior mesenteric (arteries)
Term
The __ & ___ arteries perfuse the large intestine.
Definition
Sup. & Inf. Vena cava
Term
the ___ ____ vein carries blood from the GI tract to the liver.
Definition
hepatic portal
Term
The ____ is the space that gets infected in a burst appendicitis, and the infection is called ___.
Definition
Peritoneal ; Peritonitis
Term
Upper GI (Barium Swallow)
Definition
x-ray with fluoroscopy & contrast medium (barium)
abnormalities of esophagus, stomach, duodenum
Pre Exam - **NPO p MN**, drink chalk tasting medium, various positions on x-ray table
Post - adm. laxatives & fluids; white stool
Term
Lower GI (Barium Enema)
Definition
x-ray of colon with barium thru rectum
Pre - Clear liquids, laxatives (Golytely) & enemas until clear, if not done, can hold up/cancel procedure; **NPO p MN**; cramping & urge to defecate; Assume various positions
Post - laxatives & fluids; white stool
Term
Upper GI Endoscope (EGD)
Definition
direct visualization by flexible, fibroptic endoscope
Pre - **NPO p MN**; Permit/consent signed; Pre-op med - sedation; local anesthetic
Post - NPO until return of gag reflex; Vital signs - temp; warm saline gargles - sore throat & hoarseness
**BP important to assess in case of perforation/tear and internal bleeding**
Term
Colonscopy
Definition
Direct visualization of colon
Knee-chest position
Pre-Test: clear liquids, laxatives, enemas until clear; NPO, consent signed
Post-test: VS; complications: bleeding, perforation; abdominal cramping
Term
Abdominal Ultrasound
Definition
noninvasive; ultrasound waves - masses, acities
Term
Protosigmoidoscopy
Definition
- direct visualization rectum & sigmoid colon; laxatives or enema; knee-chest position; Consent
Term
ANTIEMETICS/ ANTIHISTAMINES
Definition
Phenothiazines - depresses Chemorecptor triggerzone (CTZ);decrease nausea & vomiting
SE – major SE is decrease in BP; dry mouth, dizziness; sedation;
Term
Differnt Phenothiazines:
-prochlorperazine/____
-diphenhydramine/____
Definition
prochlorperazine/Compazine (known for extra pyramidal side effects)
diphenhydramine/Benadryl
Term
Prokinetics
Definition
Block dopamine receptors peripheral & CNS; Stimulate gastric emptying-decrease nausea & vomiting

SE - restlessness, sedation, extrapyramidal symptoms; arrthymias, constipation
Term
Prokinetic drugs:
-metoclopramide/____
-ondansetron/_____
Definition
metoclopramide/Reglan
ondansetron/Zofran
Term
Antacids
Definition
Neutralize gastric HCl - lower gastric pH
Magnesium - MOM
Aluminum-alum. hydroxide
Combination - Mylanta, Maalox
SE:
Magnesium - diarrhea; Do not give to pts with renal dx. Magnesium Citrate- diarrhea.
Aluminum - constipation
 absorp. of meds - give 1-3 hrs pc & HS
Term
H2 BLOCKERS (ANTAGONISTS)
Definition
Blocks histamine on H2 receptors on gastric parietal cells-lowers HCL secretion
SE: - Zantac - HA, malaise; Tagamet - mental confusion in elderly, agranulocytosis, aplastic anemia, neutropenia, thrombocytopenia;
Pepcid & Axid - HA, constipation, dizziness
Term
H2 Blocker drugs:

ranitidine/____
cimetidine/___
famotidine/____
nizatidine/____
Definition
-ranitidine (Zantac)
-cimetidine (Tagamet)
-famotidine (Pepcid)
-nizatidine (Axid)
Term
PROTON PUMP INHIBITORS (PPIs)
Definition
Blocks APTase enzyme ;lowers HCL secretion

SE - abd. pain, diarrhea; hematuria, proteinuria, *may increase effects of warfarin, dilantin (imp), valium;
Term
PPI drugs:
-omeprazole/____
-lansoprazole/___
-Pantoprazole/____
Definition
omeprazole (Prilosec)
lansoprazole (Prevacid)
Pantoprazole (Protonix) *common in IV format*
Term
CRYOPROTECTORS
-sucralfate/____
Definition
-Coats & protects GI tract
take 1 hour before meals and antacids 1-3 hours after meals.
SE - Constipation; absorp. Fat soluble vitamins, Dilantin, tetracycline; Antacids - effectiveness of sucralfate
Take on empty stomach
-sucralfate (Carafate)
Term
PROSTOGLANDIN ANALOGS;
-misoprostol/____
Definition
-decrease gastric acid secretion & increase mucus production
SE - diarrhea; abd. pain; avoid during pregnancy
Take with or PC & HS

-misoprostol (Cytotec)
Term
Common GI ABX
Definition
To kill Helicobacter pylori bacteria (H pylori)
Tetracycline - take on empty stomach; Avoid dairy products, sun; superinfection
Amoxicillin - allergy; Nausea; nephritis,
Flagyl - antifungal; GI distress, antabuse reaction, dark or red urine
clarithromyci (Biaxin) - macrolide; HA, diarrhea, leukopenia, increase PT
Term
Definition of nausea:
Definition
discomfort in epigastria region with desire to vomit
Term
Vomiting
Definition
forceful ejection of partially digested food, gastric secretions, etc
-Emesis; Color - RT time in contact with gastric/intestinal secretions - Bright red - active bleeding;
Coffee ground - stomach contents;
*Bile, fecal, partially digested food - S&S of obstruction*
-NG tube can be used to decrease vomiting, but continuous suction may cause hypokalemia
Term
Gastroesophogeal Reflux (GERD)
Definition
Backflow of gastric secretions into esophagus

Predisposing conditions:
-Incompetent Lower Esophageal
-Hiatal hernia
-Decreased esophageal clearance
-Decrease gastric emptying
-Irritating substances;caffeine, smoking, alcohol, chocolate, spicy foods
*Incompetent Lower Esophageal sphincter (LES) - B/W Esophagus & Stomach
scar tissue common
Term
S&S of GERD
Definition
Heartburn (pyrosis) - burning, tight sensation below sternum; may radiate to throat & jaw
Pulmonary - cough, wheeze, dyspnea
Otolaryngologic - hoarseness, sore throat, sensation, chocking
Gastric - early satiety, bloating, N&V, dysphasia; Regurgitation - hot, bitter, sour liquid
Esophagitis-inflammation
Smoking, cold or hot foods, alcohol irritate
*chest pain warrants a cardiac/MI workup*
Term
Barrett’s esophagus
Definition
-Pre cancerous lesion
-Increase risk for cancer
Term
Complications & Management of GERD
Definition
-Complications -Esophageal Stricture

Diagnostic Studies: UGI - Barium Swallow,Endoscope

-Management:
Eliminate irritating foods & beverages
Diet - 6 small meals/day- protein, fat,
Avoid milk products
raise HOB 30 degrees - 4-6 in. blocks
Avoid supine position - 2-3 hrs p eating
Term
Treatment of GERD
Definition
Drug Tx:
Antacids - neutralize gastric acid
H2 Blockers - lowers gastric acid secretion
Term
Hiatal Hernia:
Definition
protrusion of portion of stomach into esophagus
-decreased esophageal clearance
-decreased gastric emptying
S&S are same as GERD
Bend over with CO of burning pain
Surgery-Reduces the hernia
Term
PEPTIC ULCER DISEASE (PUD)
Definition
-Erosion of GI mucosa RT digestive action of HCl acid and pepsin
-Association B/W PUD & H pylori
-Develop in acid environment, but  in acid secretion not necessary
Chronic - long duration with eroding of muscular wall & fibrous tissue formation
Term
2 types of gastic ulcers:
Definition
-gastric: primarily located in antrumIrritating foods & beverages; Incompetent pyloric sphincter (B/W Stomach & duodenum); Stress ulcers, drugs (ASA, NSAIDS, steroids,) alcohol, gastritis, smoking.
Pain increase in epigastric area 1 to 2 hrs p meals

-duodenal: most in 1-2cm of duodenum..80% of all ulcers are duodenal. painful! 1/2 million new cases DX'd each year.
Psych. factors - prolonged stress; Smoking, Medications, Alcohol; Chronic Dx - COPD, Pancreatitis, Hyperparathyroidism, Increased HCL secretion, alcohol & smoking, H. pyloric, (90%)
Pain midepigastric region 2 to 4 hrs p meals
Term
Complications of PUD
Definition
-Hemorrhage- most common
-Perforation- most lethal; spillage of gastric contents into abdominal cavity
-Sudden and dramatic abdominal pain
*Abdomen feels like an ironing board
-Gastric Outlet/Pyloric Obstruction: upper abd. Pain worse during day; relieved by vomiting. Loud peristalsis
NPO; NG Tube
Term
Medical management of PUD
Definition
Symptomatic phase - bland diet
Healing phase - avoid foods & beverages that cause pain or harmful effects
Drug Tx - Antibiotics & Proton Pump (IMP)
Cryoprotective tx
Prostoglandin Analog - Cytotec - prev. gastric ulcers RT NSAIDS & ASA USE
Term
Surgical management of PUD
Definition
Billroth I - gastroduodenostomy - removal of distal 2/3 of stomach (partial gastrectomy) & anastomosis to duodenum
Billroth II - gastrojejunostomy - removal of distal 2/3 of stomach (partial gastrectomy) & anastomosis to jejunum
Lie down 30 min. after each meal (dizziness, weakness, and palpations-test ?
Preferred - prevents reoccurrence of duodenal ulcers
Vagotomy - ligation of vagus nervegastric acid secretion
Gastrectomy - removal of entire stomach
Term
Prevention/management of PUD
Definition
Limit CHO & sugars;
No fluids with meals;
6 small meals - Mod. Protein, & fat;
Rest - recumbent position
Term
Post op care after PUD repair surgery
Definition
NG tube - Do Not Irrigate or Reposition without order; Notify if no drainage
Assess NG drainage - 1500-2000cc/day nl
Initially - Bright red
6-12 hrs - dark red or brown
24-36- greenish-yellow (bile)
Assess bowel sounds- absent 24-72 hrs post op
Term
Complications of GI Surgery
Definition
Dumping Syndrome -  reservoir capacity RT removal of stomach & pyloric sphincter
loss of control of amt of gastric chyme & speed of food entering the small intestine
S/S - 15-30 min. pc; weakness, sweating, palpitation, dizziness
-- Perforation:
VS q 15 min
NPO, NG tube;
IV fluids - LR, PRBC, albumin
I & O - hourly
Broad spectrum antibiotics
Analgesics
Surgical tx - if fails to heal spontaneously
Term
Nutritional counseling for PUD Pts
Definition
Avoid - hot, spicy, high roughage foods, * milk products
increase protein - neutralizing, increases gastric secretions
increase CHO, fat - lowers neutralizing, lowers gastric secretions
6 small meals/day
Educational - 3-9 wks. to heal; Healing confirmed by Endoscope
Term
Types of Inflammatory Bowel Disease
Definition
-Crohn’s disease
-Ulcerative Colitis

General characteristics of both:
-Chronic
-Recurrent inflammation of intestinal tract
-Long periods of remission interspersed with periods of acute inflammation
-Both can be debilitating
Term
Compare and contrast Chron's vs Ulcerative Colitis
Definition
-Ulcerative colitis

Young to middle age
Diarrhea common
Cramping pain possible
Intermittent fever
Weight loss
Severe Tenemus
Rectal bleeding common
Minimal Malabsorption
uses bathroom 20x day

Location: starts distally spreads in a continuous pattern
Mucosa and submucosa

Pseudo polyps common
Appearance – no cobble stoning


-Crohn’s disease

Young
Diarrhea common
Cramping pain common
Fever common
Weight loss severe
Rare Tenemus
Rectal bleeding infrequent
Malabsorption
Location: anywhere in GI tract most frequent: terminal ileum
Segmental, entire thickness of bowel wall

Pseudo polyps rare
Cobble stoning present
Term
Chron's compared to Ulcerative colitis (II)
Definition
Ulcerative colitis

Small bowel involvement minimal
Fistulas rare
Strictures rare
Anal abscesses rare
Perforation common
Cancer increased incidence p 10 years
Recurrence after surgery – cure with colectomy


Chron's disease:
Small bowel involvement common
Fistulas common
Strictures common
Anal abscesses common
Perforation common
Cancer slightly > than general population
Recurrence after surgery –70%
Term
Colon cancer diagnostic tests
Definition
CT scan
Stool cultures
CBC (anemia)
Increased WBC
Sigmoidscope
Colonscopy
Barium enema
Term
Colorectal cancer treatments
Definition
Medications
Antimicrobials - Azulfidine
Corticosteroids – Cortisone, Prednisone
Anticholinergics -Banthine
Sedatives – Valium
Antidiarrheals – Lomotil
Immunosuppressives –Imuran, Cyclosporine
Hematinics & vitamins – Iron dextran, Cobalamin, Zinc

Surgery: Colectomy ; Total Proctorcolectomy
Term
In 2007, colorectal cancer was the #____ most common form of cancer, affecting___ % of men and ___% of women.
Definition
3rd, 9% of men, 10% of women.
Term
Risk factors for colorectal cancer
Definition
Prevalent over age 50 years
Cecum, ascending colon and sigmoid colon
20% within reach of the examining finger
50% within reach of sigmoidoscope
Cause: unknown
Risk factors : age, polps, chronic IBD, Family hx
genital and breast cancer, high fat/or low-fiber diet
Term
S&S of colorectal cancer
Definition
Mostly nonspecific
Rectal bleeding most common sign
Alternating constipation and diarrhea
Decreased size of stool, pencil thin, ribbon like
Obstruction symptoms due to smaller lumen.
Right side :asymptomatic
Vague abdominal discomfort
anemia
Term
Colorectal Cancer treatment options
Definition
The only curative treatment (colectomy)
Chemotherapy & radiation therapy
Term
Types of ostomies
Definition
Ostomy-opening to allow passage of intestinal contents from bowel to stoma
-Ileostomy- ileum to abdominal wall
-Cecostomy- cecum to abdominal wall
-Colostomy- colon to abdominal wall
----Ascending
----Transverse
----Sigmoid (may not need to wear ostomy full time, only when passing a BM)
Term
characteristics of ostomy in the sigmoid colon:
Definition
Stool formed
No change in fluids
Yes-bowel regulation
Maybe or maybe not skin barrier
Irrigation: q 24-48 hours
Term
characteristics of ostomy in the transverse colon:
Definition
Semi-liquid to formed
Increase fluids
Bowel regulation-uncommon
Skin barriers
No irrigations
Term
characteristics of ostomy in the ascending colon:
Definition
Semi-liquid
Increase fluid
No bowel regulation
Skin barriers
No irrigation
Term
Health & unhealthy stoma characteristics
Definition
Bright red or cherry red are normal
Dusky blue stoma-ischemia
Brown black- necrosis
Dark red to purple-blood supply inadequate
Paleness-anemia
Term
It is normal to not see stool in a new ostomy until ___ days post-op
Definition
2-4 days
Term
Edema around a new stomy site will not likely subside until___ weeks post op
Definition
6-8 weeks
Term
Common stoma complications
Definition
Electrolyte imbalances-Drink Gatorade
Pouch problems
Stoma shrinks-Wear pouch 5-7 days

Stoma problems
Colostomy irrigation
Rarely seen
Term
Pouch characteristics
Definition
1 piece or 2 piece snaps
Drainable or closed in
Reusable :wash in lukewarm water-no vinegar
Odor free
Pouch emptied when one-third full
Monitor F & E imbalance (Na, K, Cl); I & O
Initially 3000 cc day
Roughage diet increased as tolerated
Cleaned with H20 and soak
Shower with or without pouch
Candida - Flagyl
Term
Diet/lifestyle reqs for patients w/ ostomies
Definition
Decrease fiber
Try new foods at 3 day intervals
Odor- Flatus-onions beer, seafood, spicy pizza, cabbage, eggs
Travel don’t irrigate unless you can drink it
Drugs
Vitamins, antibiotics steroids and hormones destroy flora and drink buttermilk or yogurt or Lactaide to restore flora
-ok to swim and wear jeans
Term
Troubleshooting an ostomy w/ no drainage
Definition
concern when no drainage for > 24-48 hrs
Constant liquid drainage
Wear pouch at all times
Output- 1000-1800 initially then 800cc/da
Drink 2-3L daily
Susceptible to Metabolic Acidosis
Drink Gatorade
Tsp. Of salt and tsp. Baking soda 1 quart H20
Term
psychological issues for Pts w/ new ostomies
Definition
Misconceptions
Allay fears
Sex
Body image-grieve
ENT-enterostomal nurse
Productive and independent (Kate Jackson Richard Gere)
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