Term
|
Definition
| Less than normal amount of wbc |
|
|
Term
|
Definition
- from decreased production of neutrophils
- neutrophils are essential in limiting bacterial infection
- ↑ risk of infection
- asymptommatic, fever
|
|
|
Term
|
Definition
- lymphocytic count less than 1500
|
|
|
Term
|
Definition
|
|
Term
|
Definition
| uncontolled proliferation of wbc, often immature |
|
|
Term
|
Definition
- acute myeloid leukemia
- defect in the stem cell
- all ages, ↑ age, peaks @67, 5yr survival rate
|
|
|
Term
|
Definition
- neutropenia - fever, infection
- anemia - weakness, fatigue
- thrombocytopenia - bleeding tendecies
- hepatomegaly
- spleenomegaly
- hyperplasia of gums
- bone pain - from expansion of marrow
|
|
|
Term
|
Definition
- bruises
- result from low platelet count
|
|
|
Term
|
Definition
- pinpoint red or purple hemorrhagic spots on the skin
- result from low platelet counts
|
|
|
Term
|
Definition
- chemo
- induction therarpy→consolidation therapy
- BMT
- PBSCT
|
|
|
Term
|
Definition
- chronic myeloid leukemia
- mutation in the stem cell
- uncontrolled proliferation of cells
- >20 ↑age peak 67, 5+ yr survival rate
|
|
|
Term
|
Definition
- asymptomatic
- leukocytosis - ↑wbc >100,000
- leukostasis AEB sob, confused
- spleenomegaly
- hepatomegaly
- malaise
- anorexia/weight loss
|
|
|
Term
|
Definition
- excessive volume of leukocytes inhibits blood flow thru the capillaries
- s/s - sob, confused
|
|
|
Term
|
Definition
- chronic
- transformation
- accelerated(blast crisis)
|
|
|
Term
|
Definition
- imatinib mesylate (gleevac)
- allogeneic transplant
- BMT
- PBSCT
|
|
|
Term
|
Definition
- Acute lymphocytic leukemia
- uncontrolled proliferation of immature cells (lymphoblasts) from the stem cell
- children <15 yrs
- high cure rate
- ↑age = ↓ survival
|
|
|
Term
|
Definition
- inhibited hematopoiesis
- leukemic cell infiltration
- pain from hepatomegaly
- meningeal involvment - HA / Vomiting
|
|
|
Term
|
Definition
- complex process of the formation and maturation of blood cells
|
|
|
Term
|
Definition
- chemo
- corticosteroids
- allogeneic transplant
- monoclonal antibodies
- BMT
- PBSCT
|
|
|
Term
|
Definition
- Chronic lymphocytic leukemia
- malignant b lymphocytes
- excessive accumulation
- escape apoptosis
- older adults
- avg age is 72 yrs
- survival 15 yrs
|
|
|
Term
|
Definition
- asymptomatic
- lymphocytosis
- lymphadenopathy
- splenomegaly
- fevers
- sweats
- weight loss
- infections
- anergy - skin sensitivity tests
|
|
|
Term
|
Definition
- chemo
- monoclonal antibody
|
|
|
Term
|
Definition
- agnogenic myeloid metaplasia(aam)
- chronic disorder
- marrow fibrosis or scarring r/t pancytopenia
- angiogenesis
- disease of elderly
- 3-10 yr survival rate
|
|
|
Term
|
Definition
- neoplasms of cells of lymphoid origin
- two main types
|
|
|
Term
|
Definition
- spreads via contiguous extension of lymphatic system
- reed-sternberg cell
- early 20's and again after 50
- erythrocyte sedimenatation rate
|
|
|
Term
| Hodgkins lymphoma S/S are ? |
|
Definition
- painless lymph node enlargement
- pruritis
- some have severe pain after drinking alcohol
- herpes zoster
- fever
- sweats
- weight loss
|
|
|
Term
| Hodgkins lymphoma tx is ? |
|
Definition
- chemo
- radiation
- combination therapy with chemo and ABVD
- doxorubicin(adraimycin)
- bleomycin(blenoxane)
- vinblastine(velban)
- dacarbazine
|
|
|
Term
| Non-Hodgkin lymphomas is ? |
|
Definition
- neoplastic growth of lymphoid tissue
- spread unpredictably
- ↑age, median 67yr
|
|
|
Term
| Non-Hodgkin lymphomas S/S are ? |
|
Definition
- lymphadenopathy
- fever
- sweats
- weight loss
|
|
|
Term
| Non-Hodgkin lymphomas tx is ? |
|
Definition
- chemo
- monoclonal antibody
- bmt
- pbsct
|
|
|
Term
|
Definition
- malignant disease of the plasma cell
- m protein
|
|
|
Term
|
Definition
- bone pain
- bone breakdown
- fractures
- hypercalcemia
- renal failure
- anemia
- CNS issues
|
|
|
Term
|
Definition
- no cure
- bmt/pbsct to extend remission
- chemo
- corticosteroids
- radiation
- bisphosphonates
|
|
|
Term
|
Definition
- pamidronate(aredia)
- zoledronic acid(zometa)
- to strengthen bone, bone pain
- osteonecrosis
|
|
|
