Term
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Definition
Irreversible cox
low = antiplatelet
inter = angalgesic/antipyretic
high = anti-inflammatory
OVERDOSE = RENAL/HEPATIC FAILURE
causes
1. TINNITUS
2. SALT/H20 RETENTIN
Hepatic enzyme elevation |
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Term
|
Definition
| not generally used for anti-inflammatory effects |
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Term
|
Definition
Longest half-life may make usable for anti-platelet effect
cox1=cox2 |
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Term
|
Definition
DOES NOT PENETRATE CNS (not antipyretic) AND USEFUL BONE/DENTISTRY
cox1=cox2 |
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Term
|
Definition
•Developed for anti‐inflammatory effect
without GI effects
•DO NOT use in pt with CV risk factors
•Also Sulfa drug ‐ STEVEN-JOHNSON SYNDROME plus TOXIC EPI-NECROLYSIS
cox2>cox1 |
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Term
|
Definition
Concentrates in joints
cox2>Cox1 |
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Term
|
Definition
NOT ANTI-INFLAMMATORY
(can be given iv)
No known mechanism but potentially involves nitric oxide
good if need healing effects of inflammation (orthopedic/dentistry)or osteoarthritis but not rheumatoid or contraindicated in aspirin use (hemophiliacs)
Toxicity: Nausea/vomiting/cns --> HEPATIC NECROSIS
1) infants (lack glutathione),
2) chronic consumers of alcohol
(induced P-450) 46
450), or
3) if malnourished (depleted GSH)
dose limiter when giving mixed with narcotics |
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Term
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Definition
| Mucomyst: Glutathione substitute for acetaminophen poisening |
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Term
|
Definition
Indomethacin
Aspirin
Naproxin
Ibuprofen
diflunisal
diclofanac
celecoxib |
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Term
|
Definition
Diclofenac
Acetominophen
Indomethacin
Aspirin
Ibuprophen
Celecoxib
Diflunisal
NAPROXEN = LONG LASTING |
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Term
|
Definition
| Close patent ductus arteriosis |
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Term
|
Definition
Children with viral infections that received Aspirin
Characterized by lethargy, vomiting, rash, confusion,
seizures and loss of consciousness
Decerebrate posture |
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Term
|
Definition
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Term
|
Definition
cox 1- gi, platelet, vasuclar tone
induced in neurganglia
cox 2: brain kidney
inducible heart, endo |
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