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NonProtein Nitrogen/Renal Fxn
Clinical Chemistry
55
Chemistry
Undergraduate 3
10/11/2011

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Cards

Term
Urinary Filtrate Flow
Definition

1. Bowman's capsule

2. PCT-Promixal convoulted tuble

3. Desceding loop of Henle

4. Ascending loop of Henle

5. DCT-Distal convoulted tuble

6. collecting duct

7. renal calyces

8.ureter

9. bladder

10. urethera

Term

What are the three step of renal physiology?

 

Definition

Glomerular Filtration

Tubular Reabsorption

Tubular secretion

 

 

Term
Blood Flow in Kidney
Definition

Renat Artery

Afferent Arteriole

Glomerulus

Efferent Arteriole

Peritubular Capillaries

Vasa Recta

Renal Vein

Term
Parts of Urinary System
Definition

2 Kidneys

2 Ureters

Bladder

Nephrons

Cortex

Medulla

Term
Glomerular Filtration
Definition

In glomerulus filtrates

1st step in nephron

Term
Tubular resorption
Definition

reabsorbs fluids and electrolytes filterred by glomerulus

usually performed by passive or active transport

Term
Tubular secretion
Definition
Substances are passed through peritubular capillaries to tubular filtrate.
Term
Fxn of tubular secretion
Definition

Elimainated waste products not filtered by glomerulus

Regulates acid base balance by secreting

Term
Active transport
Definition

Uses ATP

combined with carrier protein reaches threshold concentration wher substance can not be reabsorbed and excerted in urine

Term
Passive transport
Definition

Used by urea and water

Does not need ATP

Moves subatnces from high concentration to low concentration

Term
NPN Percenatges
Definition

BUN 45%

Amino Acid 20%

Uric Acid 20 %

Creatinine 5%

Creatine 1-2%

Ammonia 0.2%

Term
BUN
Definition
direct realtionship to GFR
Term
CS of BUN
Definition

Increase in azotemia in BUN and NPN

classified into prerenal, renal and postrenal

Term
decreased BUN
Definition

decreased protein inatke

severe liver disease

overhydration

3rd mester in pregnancy

Term
soucres of BUN
Definition

exogenous protein

endogenous proetein

Term
CS of Creatinine
Definition

Increases in urinary tract obstruction

Decreases in kindey and muscle diseases

Term
CS of Uric Acid
Definition

Underproduction, over excertion = hyperuricemia

primary gout= over production

Kidney stones and renal diseases

Term
Ref Range for BUN
Definition
7-18mg/dL
Term
BUN fxn
Definition
Urea is the N-end product of prptein and AA metabolism used for screening kindeny fx
Term
Creatinine fxn
Definition
Index of renal fxn measures GFR product not filereted by gf
Term
Ref range of Creatinine
Definition

Serum: 0.5-1.5mg/dL

Urine: 0..8-2.0 gm/24hr

Term

Creatinine Clerance



 

Definition

measures GFR

U/P x V = ml/min

 

1440min/24hr

Term
fxn of Uric Acid
Definition
Aste product filtered by glomerulus
Term
Ref Range for Uric Acid Men
Definition
3.5-7.2mg/dl
Term
Ref range for uric Acid Women
Definition
2.6-6.0 mg/dl
Term
cs of ammonia
Definition
increased due to renal failure/liver disease which is toxic to CNS
Term

Acute Glomerular Nephritis-AGN

Area affected

Definition
Glomeruli, Nephron from autoimmune process
Term
Causes if Acute Glomerulonephritis
Definition

In children and young adults it is caused by group A streptococcal infection

antigen-antobody that trigger inflammatory response in basement memebrane

Term
Symptoms of Acute glomerular nephritis
Definition

rapid fever

maliase-feeling bad

nausea

oliguria-low out put of urine

hematuria

proteinuria

Term

Elevated BUn/creatinine

Decreased GFR

Definition
Acute Gloomerular Nephrtitis
Term
Area where Chronic Glomerular Nep affects
Definition

nephron-permanet damage

leads to irreversible kindeny damage

Term
Symptoms of Chronic Golmerular Nephritis
Definition

edema

Fatigue

High BP

Anemia

Metabolic acidosis

Proteinuria

Decreased urine

little urine passage to no nrine passing

Term
area affected by nephrotic sydronme
Definition
Glomercular membrane-change in permeability
Term
Nephrotic sydrome is caused by
Definition

complications due to glomerulonephritis

circulatory disorders

 

Term
Symptoms of Nephrotic syndrome
Definition

Massive proteinuria

Albuminuria

Pitting edma

High and Low albumin levels

 

Term
Area that afftected by  acute pyelonphritis
Definition
Renal Tubules
Term
Causes of Acute pyelonphritis
Definition

Gram negative bacteria

untreated cystitis and lower urinary tract infection

Term
Symptoms of acute pyelonephritis
Definition

vesicoureteral reflux

WBC

postive leukocyte esterase and nitrate

postive proteinuria

decreased SP

Term
Area affected by chronic pyelonephritis
Definition
renal tubules
Term
causes of chronic pyelonephritis
Definition
vesicoureteral reflux
Term
Symptoms of chronic py.
Definition

Polyuria

Nocturia

Term
Area affected by cystitis
Definition
bladder
Term
Causes of dysuria
Definition
intestinal flora associated with pyelonephritis
Term
Enhancing factor of GF
Definition

Presure of Glomerlular capilaries is high

Basement membrane is negativly charged

Term
Causes Acute Glomerulonephritis
Definition
Group A strepococcus in children and young adults
Term
Symptoms of Acute Glomerulonephritis
Definition

1. Onset rapid fever

2. decreased urine output

3. Malisia

4. Urina in protein

5. Blood in urine

6. Nausea

Term
Damage from acute glomerularnephritis
Definition
Glomerular Nephron
Term
Damage from chronic glomerular nephritis
Definition
permanent damage to nephron
Term
Causes of chronic glomerular nephritis
Definition
Many different possibilties that lead to irreversible damage
Term
Symptoms of chronic glomerular nephritis
Definition

1. Decreased urine

2. little to no urine output

3. Edema

4. Fatigue

5.High Blood Pressure

6.Metabolic Acidosis

Term
where nephrotic syndrome causes damage
Definition
glomercular membrane permability changes
Term
Causes of nephrotic syndrome
Definition
complications glomerulonephritis or circulatory disorders
Term
Symptoms
Definition

Massive protein in uria

Alot of lipidema

Low alot of albumina

 

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