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Nonmalignant Granulocyte and Monocyte Disorders (Monocyte)
Hematology
6
Biology
Undergraduate 4
12/04/2011

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Term
Gaucher
Definition
Autosomal Recessive
Causes a deficiency in Gluco-Cerebral Sidase, an enzyme that breaks down lipids
Large monocyte with a centered nucleus
Cytoplasm has a "crumpled paper" look
Term
Niemann-Pick
Definition
Autosomal Recessive
Found in Ashkenazi JEws
Caused by a defect in Sphingomyelinase
-Leads to an increase in sphingomyelins and siroid
Term
Sea-Blue Histocyte
Definition
Blue macrophages
Benign
Term
Lipid Storage Disorders
Definition
eg: Tay-Sachs, Sanoff Disease, Wolven Disease
Term
Monocytosis
Definition
Increase in the monocyte count
Seen in inflammation, malignancies such as Hodgkin's Lymphoma, strenuous exercise, active tuberculosis, cephalus, parasitic infections, autoimmune disorders, and trauma
Term
Monocytopenia
Definition
Decrease in the monocyte count
Seen in stem cell disorders and asplastic anemia
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