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Autosomal Recessive Causes a deficiency in Gluco-Cerebral Sidase, an enzyme that breaks down lipids Large monocyte with a centered nucleus Cytoplasm has a "crumpled paper" look |
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Autosomal Recessive Found in Ashkenazi JEws Caused by a defect in Sphingomyelinase -Leads to an increase in sphingomyelins and siroid |
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eg: Tay-Sachs, Sanoff Disease, Wolven Disease |
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Increase in the monocyte count Seen in inflammation, malignancies such as Hodgkin's Lymphoma, strenuous exercise, active tuberculosis, cephalus, parasitic infections, autoimmune disorders, and trauma |
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Decrease in the monocyte count Seen in stem cell disorders and asplastic anemia |
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