Term
|
Definition
Increase in WBC's
WBC Count: >11 x 10^9 |
|
|
Term
|
Definition
Decrease in WBC's
WBC Count: <4 x 10^9 |
|
|
Term
|
Definition
WBC Count: >25 or >50 x 10^9
A lot of immature precursors
LAP scores are increased
No Philadelphia Chromosome |
|
|
Term
|
Definition
Increase in neutrophils
>7 x 10^9
Can be caused by acute infections, hemorrhage, inflammation, intoxication, drugs, poison, stress, leukemia, or myeloproliferative disorders |
|
|
Term
|
Definition
aka Pseudoneutrophilia
aka Redistribution
Neutrophils line the vessel walls and are thus not counted, and then come out all at once when there is an infection |
|
|
Term
|
Definition
aka Agranulocytosis
Decrease in neutrophils
Can be caused by a decrease in bone marrow production, increased cell loss, increase diapedesis, hyposplenism, acute infections, chemodialysis, certain medications, X-rays, or stress |
|
|
Term
|
Definition
aka False Neutropenia
Neutrophils agglutine or disintegrate |
|
|
Term
|
Definition
Light, bright-blue, oval inclusions
Aggregates of endoplasmic reticulum
Seen in severe infections, cancer, toxic states, and burns |
|
|
Term
|
Definition
Deep-bluish-black primary granules
Seen in severe infections, cancer, toxic states, and burns |
|
|
Term
|
Definition
Clear areas of cytoplasm
Seen in Septicemia |
|
|
Term
| Chronic Granulomatis Disease |
|
Definition
| Affects the Respiratory-Burst-Oxidase System (Neutrophils engulf bacteria but cannot kill them) |
|
|
Term
| Myeloperoxidase Deficiency |
|
Definition
Lack of myeloperoxidase
Benign |
|
|
Term
| Leukocyte Adhesion Deficiency |
|
Definition
Rare
Autosomal Dominant
No leukocyte cell-adhesion proteins
-Neutrophils cannot adhere to the vessel walls and get excreted
Deadly |
|
|
Term
|
Definition
Neutrophils have large, purple granules in the cytoplasm
Missing enzymes results in increased mucopolysaccharides
Cells function normally
Seen in Hurler's Syndrome and Hunter's Syndrome |
|
|
Term
|
Definition
Autosomal Recessive
Results in death in childhood or infancy
Cells cannot kill off bacteria
Neutrophils have giant, gray-green peroxidase-positive granules in the cytoplasm
Symptoms include skin pigmentation, silvery hair, and photophobia |
|
|
Term
|
Definition
Rare
Autosomal Dominant
Neutrophils have inclusions similar to Dohle Bodies
-Made up of RNA from the endoplasmic reticulum
Neutrophils function normally
Platelets do not function normally
-Decreased and Giant
-Result in bleeding |
|
|
Term
|
Definition
Increase in eosinophils
>0.5 x 10^9 |
|
|
Term
| Hypereosinophilia Syndrome |
|
Definition
Eosinophil count: >1.5 x 10^9
Persistent
Idiopathic
Damages tissues |
|
|
Term
|
Definition
Decrease in eosinophils
Seen in acute infections, inflammatory reactions, and glucocorticosteroids |
|
|
Term
|
Definition
Increase in basophils
>.15 x 10^9
Seen in anaphylactic shock, hypoactive thyroidism, ulcerative colitis, chronic myelogenous leukemia, and chronic myeloproliferative disorders |
|
|
Term
|
Definition
|
|
Term
|
Definition
Increase in monocytes
>.8 x 10^9
Seen in inflammation, malignancies (such as Hodgkin' Lymphoma), strenuous exercise, active tuberculosis, cephalus, parasitic infections, autoimmune disorders, and trauma |
|
|
Term
|
Definition
Decrease in monocytes
<.2 x 10^9
Seen in stem cell disorders and aplastic anemia |
|
|
Term
|
Definition
Autosomal Recessive
Causes a deficiency in gluco-cerebral sidase
Large monocyte with a centered nucleus
Cytoplasm has a "crumpled paper" look |
|
|
Term
|
Definition
Autosomal Recessive
Found in Ashkenazi Jews
Caused by a defect in Sphingomyelinase
-Leads to an increase in sphingomyelins and siroid |
|
|
Term
|
Definition
|
|
